Results 31 to 40 of about 2,033,302 (264)

Combatting sepsis-induced myocardial dysfunction: emerging mechanisms and immunomodulatory breakthroughs

Frontiers in Immunology
Sepsis-induced myocardial dysfunction (SIMD) critically contributes to mortality in systemic inflammatory responses, driven by multifaceted mechanisms including dysregulated inflammation, immunosuppression, oxidative stress, and autonomic dysfunction ...
Can Liu, Can Liu, Hanfeng Liu, Hanfeng Liu, Yunxing Li, Yunxing Li, Yangxi Zeng, Yangxi Zeng, Xinyu Wang, Xinyu Wang, Yuhan Mou, Yuhan Mou, Bin Liao, Bin Liao, Juyi Wan, Juyi Wan   +15 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The Neglected Internodal Tract—A Cardiac Conduction System Structure Homologous to the Development and Regulation of the Sinoatrial Node

Reviews in Cardiovascular Medicine
The existence of internodal tracts (ITs) is controversial. Indeed, ITs in the cardiac conduction system (CCS), connected to the sinoatrial node (SAN), transmit electrical signals quickly to the left atrium and the atrioventricular node (AVN ...
Yuanqin Zhao, Juyi Wan, Bin Liao, Man Qi
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Targeting senescent cells alleviates obesity-induced metabolic dysfunction [PDF]

, 2019
Adipose tissue inflammation and dysfunction are associated with obesity-related insulin resistance and diabetes, but mechanisms underlying this relationship are unclear. Although senescent cells accumulate in adipose tissue of obese humans and rodents, a
White, Thomas A., Ming Xu, LeBrasseur, Nathan K., Marissa J. Schafer, Schafer, Marissa J., von Zglinicki, Thomas, Demaria, Marco; id_orcid, Hickson, LaTonya J, Marco Demaria, LaTonya J. Hickson, Weivoda, Megan M., Hajrunisa Cubro, Schafer, Marissa J, Arriaga, Edgar A, Hachfeld, Christine M., van Dijk, Theo H, Cubro, Hajrunisa, Hickson, LaTonya J., Doornebal, Ewald J, Thomas von Zglinicki, Arriaga, Edgar A., Michael D. Jensen, Stout, Michael B, James L. Kirkland, Judith Campisi, Chini, Eduardo N, Grande, Joseph, LeBrasseur, Nathan K, Ogrodnik, Mikolaj, Garovic, Vesna, Theo H. van Dijk, Casaclang‐Verzosa, Grace, Stout, Michael B., Aleksey Matveyenko, Pirtskhalava, Tamar, Demaria, Marco, Kuipers, Folkert; id_orcid, Larissa G. Prata, van Dijk, Theo H., Christine M. Hachfeld, Miller, Jordan D., Johnson, Kurt O., Tchkonia, Tamar, Yi Zhu, Edgar A. Arriaga, Hachfeld, Christine M, Vesna Garovic, Jensen, Michael D, Jensen, Michael D., Mikolaj Ogrodnik, Johnson, Kurt O, Megan M. Weivoda, Matveyenko, Aleksey, Kirkland, James L., Kirkland, James L, Ewald J. Doornebal, Jordan D. Miller, Weivoda, Megan M, Casaclang-Verzosa, Grace, Tamar Pirtskhalava, Thomas A. White, White, Thomas A, Verkade, Esther, Jurk, Diana, Xu, Ming, Eduardo N. Chini, Doornebal, Ewald J., Palmer, Allyson K., Campisi, Judith, Joseph Grande, Prata, Larissa G, Esther Verkade, Zhu, Yi, Chini, Eduardo N., Kurt O. Johnson, Folkert Kuipers, Allyson K. Palmer, Diana Jurk, Nathan K. LeBrasseur, Tamar Tchkonia, Prata, Larissa G., Grace Casaclang‐Verzosa, Kuipers, Folkert, Michael B. Stout, Palmer, Allyson K, Miller, Jordan D   +85 more
core   +2 more sources

Targeting the gut microbiota-bile acid axis: Therapeutic strategies for cholestatic liver disease and metabolic dysfunction-associated steatotic liver disease

EngMedicine
Cholestatic liver disease (CSLD) and metabolic dysfunction-associated steatotic liver disease (MASLD) are both associated with abnormal bile acid (BA) metabolism and have a steadily increasing incidence and prevalence worldwide.
Xingtao Zhao, Ruolan Li, Ruiqi Sun, Qiong Pan, Hongyan Lu, Jin Chai   +5 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Low Cardiorespiratory Fitness is an Independent Predictor of Metabolic Syndrome in Young Korean Adults [PDF]

, 2008
Objective: To investigate the relationship between cardio/respiratory fitness (CRF) and metabolic syndrome (MS) in young Korean men. Design: In a cross-sectional study, we examined 909 young Korean men (mean±SD age, 24.0±2 years) who were ...
Hyun-Sik Kang, Soo-Hyun Park, Shinuk Kim
core  

Aluminum adjuvant promotes liver inflammation and fibrosis in mice: A novel approach to establish a liver fibrosis animal model

Liver Research
Background and aims: Liver fibrosis is a prevalent pathological stage of various chronic liver diseases and has the potential to progress to liver cirrhosis and hepatocellular carcinoma.
Zhixian Zhu, Sen Liang, Nan Zhao, Huiling Zou, Liangjun Zhang, Xiaoxun Zhang, Jin Chai   +6 more
doaj   +1 more source

Metabolic dysfunction in a rat model of early‐life scarcity–adversity: Modulatory role of cafeteria diet

Experimental Physiology, 2018
New Findings What is the central question of this study? Early‐life adversity is associated with increased risk for obesity and metabolic dysfunction. However, it is unclear whether obesity and metabolic dysfunction result from coping strategies to deal ...
Sara C. Sagae, Bárbara Zanardini, Edson D. Ribeiro‐Paz, Ana Claudia Amaral, Gabriela A. Bronczek, Camila Lubaczeuski, Sabrina Grassiolli, Patrícia Koehler‐Santos, Jarbas Rodrigues deOliveira, Márcio Vinícius Fagundes Donadio, Charlis Raineki   +10 more
doaj   +1 more source