Results 41 to 50 of about 2,033,302 (264)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Exploring metabolic pathway disruption in the subchronic phencyclidine model of schizophrenia with the generalized singular value decomposition [PDF]

, 2011
The quantification of experimentally-induced alterations in biological pathways remains a major challenge in systems biology. One example of this is the quantitative characterization of alterations in defined, established metabolic pathways from complex ...
Dawson, Neil, Xiaolin Xiao, Brian J Morris, Xiao, X., Higham, Desmond, MacIntyre, L., Pratt, J.A., Morris, Brian J., MacIntyre, Lynsey, Higham, Desmond J, Higham, D.J., Desmond J Higham, Watson, David, Neil Dawson, Watson, David G., Judith A Pratt, Xiao, Xiaolin, Morris, B.J., Pratt, Judith, David G Watson, Pratt, Judith A., Dawson, N., Lynsey MacIntyre, Watson, D.G., Morris, Brian   +24 more
core   +1 more source

Hepatocyte SLCO4C1 is a cAMP uptake transporter for inhibiting lipogenesis and a therapeutic target for MASLD

Nature Communications
Metabolic dysfunction-associated steatotic liver disease (MASLD), the most prevalent cause of chronic liver disease worldwide, currently lacks precision medicine treatments. SLCO4C1 acts as a transporter for endogenous compounds and xenobiotics.
Xiaojia Huang, Sen Liang, Nan Zhao, Jingjing Ding, Siyi Jiang, Changpei Gan, Huayu Zhang, Lei Zuo, Yangyang Li, Xiaoxun Zhang, Jingdong Zhao, Zhixian Zhu, Liangjun Zhang, Ling Li, Ying Cheng, Xiaoman Xie, Qian Yuan, Xiaolan Yang, Jiangchuan Tian, Mindian Li, Minghua Zheng, Christopher D. Byme, Giovanni Targher, Xinshou Ouyang, Qiong Pan, Xiaolei Hu, Chuanzheng Sun, Huaizheng Liu, Jin Chai   +28 more
doaj   +1 more source

AI-driven identification of nutrition-modulated biomarkers and drug targets for cardiovascular therapeutic mechanisms

Frontiers in Pharmacology
Cardiovascular diseases (CVD) remain the leading cause of disease burden and mortality worldwide. Despite significant progress in drug treatment, this situation indicates that persistent residual risks still exist even after all feasible risk control ...
Ye Luo, Ye Luo, Ye Luo, Yuhan Mou, Yuhan Mou, Zhaoting Li, Zhaoting Li, Bin Liao, Bin Liao, Juyi Wan, Juyi Wan   +10 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Impact of anthropometric parameters on outcomes in Asians with metabolic dysfunction‐associated fatty liver disease

Journal of Cachexia, Sarcopenia and Muscle, 2023
Background We examined the incidence and predictors of clinical outcomes in metabolic dysfunction‐associated fatty liver disease (MAFLD), focusing on anthropometric parameters. Methods Adult patients with MAFLD were identified in nationwide databases and
Kyu Yeon Choi, Tae Yeon Kim, Young Eun Chon, Mi Na Kim, Joo Ho Lee, Seong Gyu Hwang, Jiwoo Lee, Mi Kyung Kwak, Eun‐Gyoung Hong, Yun Mi Choi, Yeonjung Ha   +10 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Erectile dysfunction - an update of current practice and future strategies [PDF]

, 2013
Erectile dysfunction (ED) is defined as the inability to achieve and maintain a penile erection adequate for satisfactory sexual intercourse.1 Up to 150 million men worldwide suffer from ED and this figure is likely to double by the year 2025.2 A number
Asif Muneer, Muneer, A, Jas Kalsi, Kalsi, J   +3 more
core   +1 more source

Global burden trends and future predictions of ischemic heart disease attributable to air pollution in people aged 60 years and older, 1990–2021

Frontiers in Public Health
BackgroundIschemic heart disease (IHD) is one of the leading causes of mortality and disability among the older adults. Studies have shown that air pollution (AP) exacerbates the risk of cardiovascular diseases, particularly IHD, posing significant ...
Yuanqin Zhao, Yuanqin Zhao, Lihui Liu, Lihui Liu, Wei Fan, Wei Fan, Man Qi, Man Qi, Bin Liao, Bin Liao   +9 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source