Results 51 to 60 of about 2,033,302 (264)

Cardiometabolic characterization in metabolic dysfunction–associated fatty liver disease [PDF]

, 2022
BACKGROUND: To better understand the patient's heterogeneity in fatty liver disease (FLD), metabolic dysfunction–associated fatty liver disease (MAFLD) was proposed by international experts as a new nomenclature for nonalcoholic fatty liver disease ...
Bastarrika, Gorka, Mendoza-Ferradas, F.J. (Francisco Javier), Ezponda, A. (Ana), Frühbeck, Gema, Núñez Córdoba, Jorge M., Ampuero Herrojo, Javier, Perdomo, Carolina M, Mendoza, Francisco J, Perdomo, Carolina M., Mendoza, Francisco J., Perdomo-Zelaya, C.M. (Carolina M.), Ampuero, J. (Javier), Frühbeck, G. (Gema), Ampuero, Javier, Nuñez-Cordoba, J.M. (Jorge M.), Ezponda, Ana, Núñez-Córdoba, Jorge M., Escalada, J. (Javier), Escalada, Javier, Bastarrika, G. (Gorka), Escalada-San Martín, Javier, Núñez-Córdoba, J.M., Nuñez-Cordoba, Jorge M   +22 more
core   +1 more source

Emerging role of low-frequency somatic mutations in cancer relapse: from early detection to precision oncology

Frontiers in Oncology
Somatic mutations with low variant allele frequencies offer a highly sensitive lens for detecting cancer relapse driven by diverse causes, including clonal evolution and therapy resistance.
Eunsoo Kim, Gu Seob Roh, Seong Gyu Kwon
doaj   +1 more source

Irisin ameliorates age‐associated sarcopenia and metabolic dysfunction

Journal of Cachexia, Sarcopenia and Muscle, 2023
Background Age‐associated sarcopenia is characterized of progressed loss of skeletal muscle power, mass, and function, which affects human physical activity and life quality.
Mingwei Guo, Jing Yao, Jin Li, Jun Zhang, Dongmei Wang, Hui Zuo, Yi Zhang, Bo Xu, Yinzhao Zhong, Fei Shen, Jian Lu, Shuzhe Ding, Cheng Hu, Lingyan Xu, Junjie Xiao, Xinran Ma   +15 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Metabolic control through the PGC-1 family of transcription coactivators [PDF]

, 2005
Many complex biological programs are controlled at the level of gene transcription by DNA binding transcription factors. Recent studies have revealed a novel mode of regulation by coactivator proteins, best illustrated by the PGC-1 family of coactivators.
Lin, J., Handschin, Christoph, Jiandie Lin, Christoph Handschin, Bruce M. Spiegelman, Spiegelman, Bruce M., Handschin, C., Spiegelman, B. M., Lin, Jiandie   +8 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Risk of Coronary Artery Disease Associated With Transitions in Metabolic Health in a Clinical Cohort of 69 272

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background The effect of recent onset metabolic dysfunction on coronary artery disease (CAD) risk is poorly understood. We developed a large data set linking metabolic phenotypes and clinical outcomes to quantify CAD risks associated with adverse ...
Megan M. Shuey, Rebecca T. Levinson, Megan E. Vogel, Eric Farber‐Eger, Shi Huang, Frank E. Harrel, Alyssa H. Hasty, Jonathan D. Brown, Heidi J. Silver, John R. Koethe, Joshua A. Beckman, Nancy J. Brown, Kevin D. Niswender, Nancy J. Cox, Quinn S. Wells   +14 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Metabolic Signatures of Lung Cancer in Biofluids: NMR-Based Metabonomics of Blood Plasma [PDF]

, 2011
In this work, the variations in the metabolic profile of blood plasma from lung cancer patients and healthy controls were investigated through NMR-based metabonomics, to assess the potential of this approach for lung cancer screening and diagnosis.
Joana Carrola, Brian J. Goodfellow, Carreira, Isabel M., Goodfellow, Brian J., Rocha, Cláudia M., Gil, Ana M., Carvalho, Lina, Cláudia M. Rocha, António S. Barros, Lina Carvalho, Barros, António S., Ana Gomes, Bernardo, Joao, Carrola, Joana, Sousa, Vitor, Ana M. Gil, João Bernardo, Vitor Sousa, Gomes, Ana, Iola F. Duarte, Isabel M. Carreira, Duarte, Iola F.   +21 more
core   +1 more source

Fluoxetine disrupts cholesterol metabolism in endothelial cells via SREBP2 activation

Translational Psychiatry
Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) commonly prescribed for the treatment of depressive disorders. Recent clinical reports and studies in animal models have suggested that fluoxetine increases the risk of cardiovascular diseases,
Fabiana Oliveira, Christina Papa, Tobias Hagemann, Ruby Schipper, Florian Geier, Tino Röxe, Faiqa Zulfqar, Christoph Prönnecke, Lisa Schmidt, Hryhoriy Stryhanyuk, Anne Hoffmann, Anastasia Kyselova, Christina Karantanou, Yuli Buckley, Muhammad Asad Farhan, Jesús Rafael Rodríguez-Aguilera, Saira Ambreen, He Yao, Amna Arif, Hugo N. G. Martin, Thomas Ebert, Nora Klöting, Matthias Blüher, Khurrum Shahzad, Jes-Niels Boeckel, Carolina E. Hagberg, Rima Chakaroun, Sofia-Iris Bibli, Bilal N. Sheikh   +28 more
doaj   +1 more source