Results 71 to 80 of about 2,033,302 (264)

Reduced treatment-emergent sexual dysfunction as a potential target in the development of new antidepressants [PDF]

, 2013
Pleasurable sexual activity is an essential component of many human relationships, providing a sense of physical, psychological, and social well-being.
Masdrakis, V.G., Palazzo, M.C., Baldwin, D.S.   +2 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Fatty Liver and Hyperuricemia in Workers: Combined Effects on Metabolic Dysfunction and the Role of Lifestyle Factors

Background/Objectives: Fatty liver and hyperuricemia are growing public health concerns linked to unhealthy lifestyles, yet their combined effects in working populations remain underexplored. This study investigates their associations with metabolic risk
Feng-Cheng Tang, Hon-Ke Sia, Jui-Hua Huang, Ren-Hau Li   +3 more
core   +1 more source

Differential pathways to adult metabolic dysfunction following poor nutrition at two critical developmental periods in sheep

, 2014
Epidemiological and experimental studies suggest early nutrition has long-term effects on susceptibility to obesity, cardiovascular and metabolic diseases.
Hollis, Lisa J., Karen A Lillycrop, Lucy R. Green (531955), Green, Lucy R., Jane K. Cleal (531954), Lucy R Green, Anna Warlow, Anna Warlow (531951), Poore, Kirsten R., Andrew Brewin (531952), Andrew Brewin, Lisa J Hollis, Laurence Fulford (531953), Lillycrop, Karen A., Mark A. Hanson (114427), Murray, Robert J.S., Brewin, Andrew, Cleal, Jane K., Burdge, Graham C., Fulford, Laurence, Mark A Hanson, Jane K Cleal, Graham C Burdge, Lisa J. Hollis (531949), Kirsten R Poore, Robert J S Murray, Graham C. Burdge (173729), Robert J. S. Murray (531950), Hanson, Mark A., Warlow, Anna, Kirsten R. Poore (531948), Laurence Fulford, Karen A. Lillycrop (173718)   +32 more
core   +1 more source

NAFLD becomes MASLD, frequency & characteristics of non obese metabolic dysfunction associated steatotic liver disease (MASLD) among patients seeking care at a tertiary medical facility

Journal of the Pakistan Medical Association
Objective: To determine the frequency and clinical characteristics of non-obese metabolic dysfunction-associated steatotic liver disease, distinguishing it from simple steatosis without metabolic dysfunction. Method: The cross-sectional, observational
Sumerah Jabeen, Fivzia Farooq Herekar, angbeen Aqeel, Manzoor Hussain   +3 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Metabolic dysfunction-associated steatotic liver disease and hepatocellular carcinoma: Challenges in clinical practice

The number of patients whose chronic metabolic liver disease leads to the development of hepatocellular carcinoma (HCC) is increasing. In patients with non-alcoholic fatty liver disease (NAFLD), HCC can arise in both cirrhotic and non-cirrhotic livers ...
Marta Stelmach-Mardas, Radosław Osmański, Marcin Mardas, Maria Litwiniuk   +3 more
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source