Results 121 to 130 of about 3,807,237 (401)

Metabolic engineering for valorization of macroalgae biomass.

Metabolic Engineering, 2022
Yusuke Sasaki, Y. Yoshikuni
semanticscholar   +1 more source

Chloroplastic metabolic engineering coupled with isoprenoid pool enhancement for committed taxanes biosynthesis in Nicotiana benthamiana

Nature Communications, 2019
Production of the anticancer drug Taxol and its precursors in heterologous hosts is more sustainable than extraction from tissues of yew trees or chemical synthesis.
Jianhua Li, I. Mutanda, Kaibo Wang, Lei Yang, Jia-Wei Wang, Yong Wang   +5 more
semanticscholar   +1 more source

Division of Metabolic Engineering [PDF]

, 2007
この論文は国立情報学研究所の学術雑誌公開支援事業により電子化されまし
宮代 博継, 左 風, 服部 征雄, 馬 超美, 高 江静   +4 more
core   +1 more source

Targeted metabolomics reveals novel diagnostic biomarkers for colorectal cancer

Molecular Oncology, EarlyView.
This study employed targeted metabolomic profiling to identify 302 distinct metabolites present in platelet‐rich plasma (PRP), revealing aberrant metabolic profiles amongst individuals diagnosed with colorectal cancer (CRC). Compared to carcinoembryonic antigen (CEA) and cancer antigen 19‐9 (CA199), our metabolite panel showed improved sensitivity ...
Zuojian Hu, Fenglin Shen, Yang Liu, Ziqing Zhong, Yongling Chen, Zhiyuan Xia, Cuiju Mo, Hongxiu Yu   +7 more
wiley   +1 more source

Advances on systems metabolic engineering of Bacillus subtilis as a chassis cell

Synthetic and Systems Biotechnology, 2020
The Gram-positive model bacterium Bacillus subtilis, has been broadly applied in various fields because of its low pathogenicity and strong protein secretion ability, as well as its well-developed fermentation technology. B.
Mengjie Xiang, Qian Kang, Dawei Zhang
doaj  

Algorithms for Molecular Biology / Designing minimal microbial strains of desired functionality using a genetic algorithm [PDF]

, 2015
Background: The rational, in silico prediction of gene-knockouts to turn organisms into efficient cell factories is an essential and computationally challenging task in metabolic engineering.
Hanscho, Michael, Jungreuthmayer, Christian, Nair, Govind, Zanghellini, J\ufcrgen   +3 more
core   +1 more source

Inhibition of acyl‐CoA synthetase long‐chain isozymes decreases multiple myeloma cell proliferation and causes mitochondrial dysfunction

Molecular Oncology, EarlyView.
Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy, Heather Fairfield, Victoria E. DeMambro, Samaa Fadel, Carlos A. Gartner, Michelle Karam, Christian Potts, Princess Rodriguez, Ya‐Wei Qiang, Habib Hamidi, Xiangnan Guan, Calvin P. H. Vary, Michaela R. Reagan   +12 more
wiley   +1 more source

Microbial metabolic engineering

Microbial Biotechnology, 2022
Lawrence P. Wackett
doaj   +1 more source

Unleashing the power of energy storage: Engineering β-oxidation pathways for polyketide production

Synthetic and Systems Biotechnology, 2020
Overproduction of polyketides has been a challenge for metabolic engineering for decades. However, recent studies have demonstrated that in both native host and heterologous host, engineering β -oxidation pathways can lead to dramatic improvement of ...
Bin Wang, Huimin Zhao
doaj  

Metabolic Engineering of Oleaginous Yeasts for Production of Fuels and Chemicals

Frontiers in Microbiology, 2017
Oleaginous yeasts have been increasingly explored for production of chemicals and fuels via metabolic engineering. Particularly, there is a growing interest in using oleaginous yeasts for the synthesis of lipid-related products due to their high ...
Shuobo Shi, Shuobo Shi, Huimin Zhao, Huimin Zhao, Huimin Zhao   +4 more
doaj   +1 more source