Results 251 to 260 of about 330,730 (300)

Metabolic engineering of Streptomyces explomaris for increased production of the reverse antibiotic nybomycin. [PDF]

Microb Cell Fact
Shu W, Stegmüller J, Rodriguez-Estevez M, Rückert-Reed C, Kalinowski J, Gromyko O, Rebets Y, Luzhetskyy A, Wittmann C.   +8 more
europepmc   +1 more source

Systematic metabolic engineering of <i>Escherichia coli</i> for high-level production of pseudouridine via pathway optimization and precursor enhancement. [PDF]

Synth Syst Biotechnol
Song J, Shen W, Xia Y, Zhou L, Zhou Y, Yang H, Chen X.   +6 more
europepmc   +1 more source

Metabolic engineering of doxorubicin biosynthesis through P450-redox partner optimization and structural analysis of DoxA. [PDF]

Nat Commun
Koroleva A, Artukka E, Yamada K, Newmister SA, Harte RJ, Boesger H, Londen M, Sanders JN, Tirkkonen H, Kannisto M, Kuin RCM, Hulst M, Wang R, Leskinen E, Barillec M, Niemi J, van Wezel GP, Neefjes J, Nybo SE, Houk KN, Sherman DH, Kim RQ, Metsä-Ketelä M.   +22 more
europepmc   +1 more source

Evolution of the Metabolic Engineering Community

Metabolic Engineering, 2018
Metabolic Engineering emerged as an independent research field in the late 1980s and is often seen defined by two seminal papers in published in Science by James E. Bailey and Gregory Stephanopoulos in 1991 (Bailey, 1991, Stephanopoulos and Vallino, 1991)
Nielsen, Jens, Lee, Sang Yup
openaire   +5 more sources

The future of metabolic engineering and synthetic biology: Towards a systematic practice [PDF]

Metabolic Engineering, 2012
Industrial biotechnology promises to revolutionize conventional chemical manufacturing in the years ahead, largely owing to the excellent progress in our ability to re-engineer cellular metabolism.
Vikramaditya G Yadav, Marjan de Mey, Chin Giaw Lim   +2 more
exaly   +2 more sources

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Metabolic Engineering

Annual Review of Biomedical Engineering, 1999
▪ Abstract  Metabolic engineering is the science that combines systematic analysis of metabolic and other pathways with molecular biological techniques to improve cellular properties by designing and implementing rational genetic modifications. As such, metabolic engineering deals with the measurement of metabolic fluxes and elucidation of their ...
M, Koffas, C, Roberge, K, Lee, G, Stephanopoulos   +3 more
openaire   +3 more sources

Metabolic Engineering

2007
Metabolic engineering is a powerful methodology aimed at intelligently designing new biological pathways, systems, and ultimately phenotypes through the use of recombinant DNA technology. Built largely on the theoretical and computational analysis of chemical systems, the field has evolved to incorporate a growing number of genome scale experimental ...
R Michael, Raab, Keith, Tyo, Gregory, Stephanopoulos   +2 more
openaire   +3 more sources

Metabolic Engineering

Applied Microbiology and Biotechnology, 2001
Metabolic engineering has developed as a very powerful approach to optimising industrial fermentation processes through the introduction of directed genetic changes using recombinant DNA technology. Successful metabolic engineering starts with a careful analysis of cellular function; based on the results of this analysis, an improved strain is designed
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Developments in metabolic engineering

Current Opinion in Biotechnology, 1997
The complete sequencing of several microbial genomes has resulted in the increased availability of genes for metabolic engineering. The number of databases and computational tools to deal with this information has also increased. This development has stimulated, and will continue to stimulate, advances in metabolic engineering. Specific recent advances
, Cameron, , Chaplen
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Metabolic engineering

Current Opinion in Biotechnology, 1994
Metabolic engineering is not another form of classic manipulation of intermediary metabolism; rather, it is the purposeful design of metabolic networks. The metabolic engineering approach examines biochemical reactions in their entirety, rather than individually, and is concerned with the construction of novel pathways, the thermodynamic feasibility of
openaire   +3 more sources