Results 81 to 90 of about 574,220 (331)

Characterizing and engineering promoters for metabolic engineering of Ogataea polymorpha

Synthetic and Systems Biotechnology, 2022
Bio-manufacturing via microbial cell factory requires large promoter library for fine-tuned metabolic engineering. Ogataea polymorpha, one of the methylotrophic yeasts, possesses advantages in broad substrate spectrum, thermal-tolerance, and capacity to ...
Chunxiao Yan, Wei Yu, Xiaoxin Zhai, Lun Yao, Xiaoyu Guo, Jiaoqi Gao, Yongjin J. Zhou   +6 more
doaj  

Division of Metabolic Engineering [PDF]

, 2006
この論文は国立情報学研究所の学術雑誌公開支援事業により電子化されまし
中村 憲夫, 宮代 博継, 左 風, 服部 征雄, 横澤 隆子, 高 江静, 黒岩 純子   +6 more
core   +1 more source

(Im) Perfect robustness and adaptation of metabolic networks subject to metabolic and gene-expression regulation: marrying control engineering with metabolic control analysis [PDF]

, 2013
Background: Metabolic control analysis (MCA) and supply–demand theory have led to appreciable understanding of the systems properties of metabolic networks that are subject exclusively to metabolic regulation.
Fromion, V., He, F., Westerhoff, H.V.
core   +5 more sources

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Cell-free protein synthesis enabled rapid prototyping for metabolic engineering and synthetic biology

Synthetic and Systems Biotechnology, 2018
Advances in metabolic engineering and synthetic biology have facilitated the manufacturing of many valuable-added compounds and commodity chemicals using microbial cell factories in the past decade.
Lihong Jiang, Jiarun Zhao, Jiazhang Lian, Zhinan Xu   +3 more
doaj  

Biosynthesis of value-added bioproducts from hemicellulose of biomass through microbial metabolic engineering

Metabolic Engineering Communications, 2022
Hemicellulose is the second most abundant carbohydrate in lignocellulosic biomass and has extensive applications. In conventional biomass refinery, hemicellulose is easily converted to unwanted by-products in pretreatment and therefore can't be fully ...
Biao Geng, Xiaojing Jia, Xiaowei Peng, Yejun Han   +3 more
doaj  

Transcription Factor Engineering for High-Throughput Strain Evolution and Organic Acid Bioproduction: A Review

Frontiers in Bioengineering and Biotechnology, 2020
Metabolic regulation of gene expression for the microbial production of fine chemicals, such as organic acids, is an important research topic in post-genomic metabolic engineering.
Jia-Wei Li, Xiao-Yan Zhang, Hui Wu, Yun-Peng Bai   +3 more
doaj   +1 more source

Division of Metabolic Engineering [PDF]

, 2007
この論文は国立情報学研究所の学術雑誌公開支援事業により電子化されまし
宮代 博継, 左 風, 服部 征雄, 馬 超美, 高 江静   +4 more
core   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

COMBINATORIAL APPROACHES FOR INVERSE METABOLIC ENGINEERING APPLICATIONS

Computational and Structural Biotechnology Journal, 2012
Traditional metabolic engineering analyzes biosynthetic and physiological pathways, identifies bottlenecks, and makes targeted genetic modifications with the ultimate goal of increasing the production of high-value products in living cells.
Georgios Skretas, Fragiskos N. Kolisis
doaj   +3 more sources