Results 81 to 90 of about 3,807,237 (401)
Back to the future: Why we need enzymology to build a synthetic metabolism of the future
Beilstein Journal of Organic Chemistry, 2019 Biology is turning from an analytical into a synthetic discipline. This is especially apparent in the field of metabolic engineering, where the concept of synthetic metabolism has been recently developed.
Tobias J. Erb
doaj +1 more source
Thermal resonance in cancer [PDF]
arXiv, 2021 In the end of the second decade of 20th century, Warburg showed how cancer cells present a fermentative respiration process, related to a metabolic injury. Here, we develop an analysis of the cell process based on its heat outflow, in order to control cancer progression.
arxiv
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
An ensemble approach to the study of the emergence of metabolic and proliferative disorders via Flux Balance Analysis [PDF]
EPTCS 130, 2013, pp. 92-97, 2013 An extensive rewiring of cell metabolism supports enhanced proliferation in cancer cells. We propose a systems level approach to describe this phenomenon based on Flux Balance Analysis (FBA). The approach does not explicit a cell biomass formation reaction to be maximized, but takes into account an ensemble of alternative flux distributions that match ...
arxiv +1 more source
Department of Metabolic Engineering [PDF]
, 2002 薬物代謝工学部門は和漢薬の薬効，毒性発現に関与する代謝系の分子生物学的研究を発展させることを設置目的とし，①和漢薬の薬効発現に関与する腸内細菌遺伝子の解析，②薬物代謝機能調節遺伝子の解明とその応用，③腎毒性物質産生機構の分子生物学的解明とその制御に関する研究を課題として取りあげ，和漢薬の薬効発現機構，生体へのレスポンスなどの基礎的研究を通じて，和漢薬の科学的評価や臨床応用をはかることを目指している。主な研究題目を以下に示す。1.
中村 憲夫 +3 more
core +2 more sources
A stepwise emergence of evolution in the RNA world
FEBS Letters, EarlyView.How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley +1 more source
Towards a modeling, optimization and predictive control framework for fed-batch metabolic cybergenetics [PDF]
arXiv, 2023 Biotechnology offers many opportunities for the sustainable manufacturing of valuable products. The toolbox to optimize bioprocesses includes \textit{extracellular} process elements such as the bioreactor design and mode of operation, medium formulation, culture conditions, feeding rates, etc.
arxiv
FEBS Letters, EarlyView.The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp +5 more
wiley +1 more source
The LASER database: Formalizing design rules for metabolic engineering
Metabolic Engineering Communications, 2015 The ability of metabolic engineers to conceptualize, implement, and evaluate strain designs has dramatically increased in the last decade. Unlike other engineering fields, no centralized, open-access, and easily searched repository exists for cataloging ...
James D. Winkler +2 more
doaj
Fast Reconstruction of Compact Context-Specific Metabolic Network Models [PDF]
, 2013 Systemic approaches to the study of a biological cell or tissue rely increasingly on the use of context-specific metabolic network models. The reconstruction of such a model from high-throughput data can routinely involve large numbers of tests under different conditions and extensive parameter tuning, which calls for fast algorithms.
arxiv +1 more source