Results 1 to 10 of about 2,439,426 (195)

Enhanced flux potential analysis links changes in enzyme expression to metabolic flux [PDF]

Molecular Systems Biology
Algorithms that constrain metabolic network models with enzyme levels to predict metabolic activity assume that changes in enzyme levels are indicative of flux variations.
Xuhang Li, Albertha J M Walhout, L Safak Yilmaz   +2 more
doaj   +2 more sources

Reprogramming Metabolic Flux in Escherichia Coli to Enhance Chondroitin Production [PDF]

Advanced Science
Reprogramming metabolic flux is a promising approach for constructing efficient microbial cell factories (MCFs) to produce chemicals. However, how to boost the transmission efficiency of metabolic flux is still challenging in complex metabolic pathways ...
Chunlei Zhao, Xiaomin Li, Liang Guo, Cong Gao, Wei Song, Wanqing Wei, Jing Wu, Liming Liu, Xiulai Chen   +8 more
doaj   +2 more sources

The metabolic origins of non-photorespiratory CO2 release during photosynthesis: a metabolic flux analysis

Plant Physiology, 2021
Metabolic flux analysis of photosynthesizing leaves suggests glucose-6-phosphate oxidation is the main source of non-photorespiratory CO2 loss.
Yuan Xu, Xinyu Fu, T. Sharkey, Y. Shachar-Hill, and Berkley J Walker   +4 more
semanticscholar   +1 more source

A graph neural network model to estimate cell-wise metabolic flux using single-cell RNA-seq data

Genome Research, 2021
The metabolic heterogeneity and metabolic interplay between cells are known as significant contributors to disease treatment resistance. However, with the lack of a mature high-throughput single-cell metabolomics technology, we are yet to establish ...
Norah Alghamdi, Wennan Chang, Pengtao Dang, Xiaoyu Lu, Changlin Wan, S. Gampala, Zhi Huang, Jiashi Wang, Qin Ma, Y. Zang, M. Fishel, Sha Cao, Chi Zhang   +12 more
semanticscholar   +1 more source

Multi-omics-based label-free metabolic flux inference reveals obesity-associated dysregulatory mechanisms in liver glucose metabolism

iScience, 2022
Summary: Glucose homeostasis is maintained by modulation of metabolic flux. Enzymes and metabolites regulate the involved metabolic pathways. Dysregulation of glucose homeostasis is a pathological event in obesity.
Saori Uematsu, Satoshi Ohno, Kaori Y. Tanaka, Atsushi Hatano, Toshiya Kokaji, Yuki Ito, Hiroyuki Kubota, Ken-ichi Hironaka, Yutaka Suzuki, Masaki Matsumoto, Keiichi I. Nakayama, Akiyoshi Hirayama, Tomoyoshi Soga, Shinya Kuroda   +13 more
doaj   +1 more source

ΔFBA: Predicting metabolic flux alterations using genome-scale metabolic models and differential transcriptomic data

bioRxiv, 2021
Genome-scale metabolic models (GEMs) provide a powerful framework for simulating the entire set of biochemical reactions occurring in a cell. Constraint-based modeling tools like flux balance analysis (FBA) developed for the purposes of predicting ...
S. Ravi, Rudiyanto Gunawan
semanticscholar   +1 more source

Molecular regulation of conditioning film formation and quorum quenching in sulfate reducing bacteria

Frontiers in Microbiology, 2022
Sensing surface topography, an upsurge of signaling biomolecules, and upholding cellular homeostasis are the rate-limiting spatio-temporal events in microbial attachment and biofilm formation.
Dheeraj Raya, Dheeraj Raya, Aritree Shreya, Aritree Shreya, Anil Kumar, Shiv Kumar Giri, David R. Salem, Etienne Z. Gnimpieba, Etienne Z. Gnimpieba, Venkataramana Gadhamshetty, Venkataramana Gadhamshetty, Saurabh Sudha Dhiman, Saurabh Sudha Dhiman, Saurabh Sudha Dhiman   +13 more
doaj   +1 more source

UDP-glucosyltransferase regulates grain size and abiotic stress tolerance associated with metabolic flux redirection in rice

Nature Communications, 2020
Grain size is an important component trait of grain yield, which is frequently threatened by abiotic stress. However, little is known about how grain yield and abiotic stress tolerance are regulated.
Nai-Qian Dong, Yuwei Sun, Tao Guo, Chuan-Lin Shi, Yi-Min Zhang, Yi Kan, You-Huang Xiang, Hai Zhang, Yi-Bing Yang, Ya-Chao Li, Huai-Yu Zhao, Hong Yu, Zi-Qi Lu, Yong Wang, Wang-Wei Ye, Jun-Xiang Shan, Hong-Xuan Lin   +16 more
semanticscholar   +1 more source

Using the inner membrane of Escherichia coli as a scaffold to anchor enzymes for metabolic flux enhancement

Engineering in Life Sciences, 2023
Clustering enzymes in the same metabolic pathway is a natural strategy to enhance productivity. Synthetic protein, RNA and DNA scaffolds have been designed to artificially cluster multiple enzymes in the cell, which require complex construction processes
You Wang, Yushu Wang, Yuqi Wu, Yang Suo, Huaqing Guo, Yineng Yu, Ruonan Yin, Rui Xi, Jiajie Wu, Nan Hua, Yuehan Zhang, Shaobo Zhang, Zhenming Jin, Lin He, Gang Ma   +14 more
doaj   +1 more source

Cycles, sources, and sinks: Conceptualizing how phosphate balance modulates carbon flux using yeast metabolic networks

eLife, 2021
Phosphates are ubiquitous molecules that enable critical intracellular biochemical reactions. Therefore, cells have elaborate responses to phosphate limitation. Our understanding of long-term transcriptional responses to phosphate limitation is extensive.
Ritu Gupta, Sunil Laxman
doaj   +1 more source