Results 181 to 190 of about 2,439,575 (338)

Digital twins for in vivo metabolic flux estimations in patients with brain cancer. [PDF]

Cell Metab
Meghdadi B, Al-Holou WN, Scott AJ, Mittal A, Liang N, Sravya P, Achreja A, O'Brien A, Do K, Wu Z, Feng J, Qi NR, Tarnal V, Venneti S, Miller CR, Sarkaria JN, Zhou W, Lawrence TS, Lyssiotis CA, Wahl DR, Nagrath D.   +20 more
europepmc   +1 more source

Cutaneous Phosphorylated Alpha‐Synuclein in Lewy Body Dementia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine the test performance of cutaneous phosphorylated alpha‐synuclein (P‐SYN) in dementia with Lewy bodies (DLB), individuals with reduced Montreal Cognitive Assessment (MoCA) and healthy controls. Methods This is the first subgroup analysis of the Synuclein‐One study, a prospective, blinded study evaluating P‐SYN detection ...
Christopher H. Gibbons, Todd Levine, Charles H. Adler, Bailey Bellaire, Ningshan Wang, Pinky Agarwal, Georgina M. Aldridge, Alexandru Barboi, Daniel Claassen, Virgilio G. H. Evidente, Douglas Galasko, Alejandra Gonzalez‐Duarte, Ramon Gil, Mark Gudesblatt, Stuart H. Isaacson, Horacio Kaufmann, Pravin Khemani, Rajeev Kumar, Guillaume Lamotte, Andy J. Liu, Nikolaus R. McFarland, Mitchell G. Miglis, Adam Reynolds, Gregory A. Sahagian, Marie‐Helene Saint‐Hilaire, Julie B. Schwartzbard, Wolfgang Singer, Michael J. Soileau, Steven Vernino, Patricio Millar Vernetti, Oleg Yerstein, Roy Freeman   +31 more
wiley   +1 more source

Cannabidiol perturbs macrophage polarization by interfering with the metabolic flux and PI3K/Akt pathway. [PDF]

Sci Rep
Sukdee T, Wongprom B, Pattarakarnkul T, Leelahavanichkul A, Charoensappakit A, Sae-Khow K, Yukhet P, Vilaivan T, Palaga T.   +8 more
europepmc   +1 more source

Effects of Biological Sex and Age on Cerebrospinal Fluid Markers—A Retrospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cerebrospinal fluid (CSF) analysis is a key diagnostic tool for neurological diseases. To date, only a few studies have investigated in larger cohorts the effect of age and biological sex on diagnostic markers extracted from CSF. Methods For this retrospective observational study, 4163 CSF findings (2012–2020) were evaluated.
Isabel‐Sophie Hafer, Simon Faissner, Ralf Gold, Aiden Haghikia   +3 more
wiley   +1 more source

Glucose priming effect on microbial intercellular metabolic flux diversity in a marine intertidal sediment. [PDF]

PLoS One
Ji T, Xu Z, Wen L, Yang Y, Wu Y, Zhao X, Yao R, Liu R, Xu Y, Wu W.   +9 more
europepmc   +1 more source

A recruiting protein of geranylgeranyl diphosphate synthase controls metabolic flux toward chlorophyll biosynthesis in rice

Proceedings of the National Academy of Sciences of the United States of America, 2017
F. Zhou, Chengyuan Wang, Michael Gutensohn, Ling Jiang, Peng Zhang, Dabing Zhang, N. Dudareva, Shan Lu   +7 more
semanticscholar   +1 more source

Clinically Relevant Outcome Measures in Women With Adrenoleukodystrophy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Adrenoleukodystrophy is a rare inherited peroxisomal disease caused by pathogenic variants in the ABCD1 gene located on the X chromosome. Although the most severe central nervous system and adrenal complications typically affect only men with adrenoleukodystrophy, the majority of women develop myeloneuropathy symptoms in adulthood.
Chenwei Yan, Elizabeth I. Pierpont, Amena S. Fine, Reena V. Kartha   +3 more
wiley   +1 more source

Protocol to assess retinal metabolic flux of mice via stable isotope-resolved metabolomics. [PDF]

STAR Protoc
Komissarov G, Pandey K, Nolan ND, Winogrodzki T, Hass DT, Demirkol A, Robbings BM, Hurley JB, Tsang SH.   +8 more
europepmc   +1 more source

Optogenetic switch for controlling the central metabolic flux of Escherichia coli.

Metabolic Engineering, 2019
S. T. Tandar, Sachie Senoo, Yoshihiro Toya, H. Shimizu   +3 more
semanticscholar   +1 more source

Monocyte LOXHD1 and RHOB Expression Predictive of Progressive Systemic Sclerosis–Associated Interstitial Lung Disease

Arthritis Care &Research, EarlyView.
Objective A leading cause of death among patients with scleroderma (SSc), interstitial lung disease (ILD) remains challenging to prognosticate. The discovery of biomarkers that accurately determine which patients would benefit from close monitoring and aggressive therapy would be an essential clinical tool.
Cristina M. Padilla, Robert Lafyatis, Kevin F. Gibson, Christina Morse, Eleanor Valenzi, Xiaoping Chen, Xiaoyun Li, Yanwu Zhao, Yongseok Park, Dana Ascherman, Jonathan Minden, Robyn Domsic, Yingze Zhang, Daniel J. Kass   +13 more
wiley   +1 more source