Results 11 to 20 of about 2,439,575 (338)
Flux-P: Automating Metabolic Flux Analysis [PDF]
Metabolites, 2012 Quantitative knowledge of intracellular fluxes in metabolic networks is invaluable for inferring metabolic system behavior and the design principles of biological systems.
Birgitta E. Ebert +3 more
doaj +5 more sources
Metabolic Flux Analysis—Linking Isotope Labeling and Metabolic Fluxes [PDF]
Metabolites, 2020 Metabolic flux analysis (MFA) is an increasingly important tool to study metabolism quantitatively. Unlike the concentrations of metabolites, the fluxes, which are the rates at which intracellular metabolites interconvert, are not directly measurable ...
Yujue Wang +4 more
semanticscholar +4 more sources
Bayesian metabolic flux analysis reveals intracellular flux couplings [PDF]
Bioinformatics, 2018 Motivation Metabolic flux balance analysis (FBA) is a standard tool in analyzing metabolic reaction rates compatible with measurements, steady-state and the metabolic reaction network stoichiometry.
Markus Heinonen +6 more
semanticscholar +7 more sources
Flux networks in metabolic graphs [PDF]
Physical Biology, 2009 A metabolic model can be represented as bipartite graph comprising linked reaction and metabolite nodes. Here it is shown how a network of conserved fluxes can be assigned to the edges of such a graph by combining the reaction fluxes with a conserved ...
Dantzig G B +9 more
core +3 more sources
Metabolic flux analysis of secondary metabolism in plants
Metabolic Engineering Communications, 2020 Numerous secondary metabolites from plants are important for their medicinal, nutraceutical or sensory properties. Recently, significant progress has been made in the identification of the genes and enzymes of plant secondary metabolic pathways.
Meng-Ling Shih, J. Morgan
semanticscholar +4 more sources
Principal metabolic flux mode analysis [PDF]
Bioinformatics, 2017 Abstract Motivation In the analysis of metabolism, two distinct and complementary approaches are frequently used: Principal component analysis (PCA) and stoichiometric flux analysis. PCA is able to capture the main modes of variability in a set of experiments and does not make many prior ...
Bhadra, Sahely +4 more
openaire +4 more sources
Frontiers in Endocrinology, 2022 BackgroundGlycine is a dietary non-essential amino acid that is low in obesity and increases following bariatric surgery. However, the exact mechanism responsible remains unclear and it is unknown whether hypoglycinemia is a cause or consequence of ...
Hong Chang Tan +7 more
doaj +1 more source
Enzyme Assembly for Compartmentalized Metabolic Flux Control
Metabolites, 2020 Enzyme assembly by ligand binding or physically sequestrating enzymes, substrates, or metabolites into isolated compartments can bring key molecules closer to enhance the flux of a metabolic pathway.
Xueqin Lv +5 more
doaj +1 more source
Communications Biology, 2020 Metabolic flux technology with the Seahorse bioanalyzer has emerged as a standard technique in cellular metabolism studies, allowing for simultaneous kinetic measurements of respiration and glycolysis. Methods to extend the utility and versatility of the
A. Little +9 more
semanticscholar +1 more source
Monitoring Glycolysis and Respiration Highlights Metabolic Inflexibility of Cryptococcus neoformans
Pathogens, 2020 Cryptococcus neoformans is a human fungal pathogen that adapts its metabolism to cope with limited oxygen availability, nutrient deprivation and host phagocytes.
Sophie Lev +6 more
doaj +1 more source