Results 191 to 200 of about 2,439,575 (338)

Corrigendum: Metabolic flux in macrophages in obesity and type-2 diabetes. [PDF]

J Pharm Pharm Sci
Wong A, Sun Q, Latif II, Karwi QG.
europepmc   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

Biocompatible SABRE Hyperpolarization of [1-¹³C]Ketoleucine for Cellular Metabolic Flux Sensing. [PDF]

Chemistry
TomHon P, Gyesi J, Abdurraheem A, McBride S, Samoilenko A, Oladun C, Curran E, Pike M, Welch SD, Scofield S, Goodson BM, Sadagurski M, Theis T, Chekmenev EY.   +13 more
europepmc   +1 more source

3D (Bio) Printing Combined Fiber Fabrication Methods for Tissue Engineering Applications: Possibilities and Limitations

Advanced Functional Materials, EarlyView.
Biofabrication aims at providing innovative technologies and tools for the fabrication of tissue‐like constructs for tissue engineering and regenerative medicine applications. By integrating multiple biofabrication technologies, such as 3D (bio) printing with fiber fabrication methods, it would be more realistic to reconstruct native tissue's ...
Waseem Kitana, Indra Apsite, Leonid Ionov   +2 more
wiley   +1 more source

Integrative Metabolic-Flux Platform for Analysis, Contextualization, and Targeting (IMPACT): bridging untargeted and targeted flux analysis. [PDF]

Bioinformatics
Starke C, Hendriks J, Wahrheit J, Fluitman F, Beekwilder J, Schempp FM, Hiller K.   +6 more
europepmc   +1 more source

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

13CFLUX - third-generation high-performance engine for isotopically (non)stationary 13C metabolic flux analysis. [PDF]

Bioinformatics
Stratmann A, Beyß M, Jadebeck JF, Wiechert W, Nöh K.   +4 more
europepmc   +1 more source

Revealing metabolic mechanisms of interaction in the anaerobic digestion microbiome by flux balance analysis.

Metabolic Engineering, 2020
Arianna Basile, S. Campanaro, Adam Kovalovszki, Guido Zampieri, Alessandro Rossi, I. Angelidaki, G. Valle, L. Treu   +7 more
semanticscholar   +1 more source

Patterning the Void: Combining L‐Systems with Archimedean Tessellations as a Perspective for Tissue Engineering Scaffolds

Advanced Functional Materials, EarlyView.
This study introduces a novel multi‐scale scaffold design using L‐fractals arranged in Archimedean tessellations for tissue regeneration. Despite similar porosity, tiles display vastly different tensile responses (1–100 MPa) and deformation modes. In vitro experiments with hMSCs show geometry‐dependent growth and activity. Over 55 000 tile combinations
Maria Kalogeropoulou, Kenny A. van Kampen, Pierpaolo Fucile, Carlos Mota, Lorenzo Moroni   +4 more
wiley   +1 more source

Phenylalanine Ammonia-Lyase: A Core Regulator of Plant Carbon Metabolic Flux Redistribution-From Molecular Mechanisms and Growth Modulation to Stress Adaptability. [PDF]

Plants (Basel)
Wu X, Zhu S, He L, Cheng G, Li T, Meng W, Wen F.   +6 more
europepmc   +1 more source