Results 21 to 30 of about 2,439,575 (338)

Systemic Lactate Acts as a Metabolic Buffer in Humans and Prevents Nutrient Overflow in the Postprandial Phase

Frontiers in Nutrition, 2022
On an organismal level, metabolism needs to react in a well-orchestrated manner to metabolic challenges such as nutrient uptake. Key metabolic hubs in human blood are pyruvate and lactate, both of which are constantly interconverted by very fast exchange
Lisa Schlicker, Lisa Schlicker, Gang Zhao, Gang Zhao, Christian-Alexander Dudek, Christian-Alexander Dudek, Hanny M. Boers, Michael Meyer-Hermann, Michael Meyer-Hermann, Michael Meyer-Hermann, Doris M. Jacobs, Karsten Hiller   +11 more
doaj   +1 more source

Increased NADPH Supply Enhances Glycolysis Metabolic Flux and L-methionine Production in Corynebacterium glutamicum

Foods, 2022
Corynebacterium glutamicum is an important strain for the industrial production of amino acids, but the fermentation of L-methionine has not been realized.
Bingnan Liu, Xinyu Sun, Yue Liu, Mengmeng Yang, Liang Wang, Ying Li, Jihui Wang   +6 more
doaj   +1 more source

MultiMetEval: comparative and multi-objective analysis of genome-scale metabolic models [PDF]

, 2012
Comparative metabolic modelling is emerging as a novel field, supported by the development of reliable and standardized approaches for constructing genome-scale metabolic models in high throughput.
A Freitag, A Gevorgyan, A Mithani, Albert Gevorgyan, AM Feist, AM Feist, AM Feist, Andrzej M. Kierzek, AP Burgard, BA Pfeifer, CS Henry, D Nagrath, DC Alexander, DC Stevens, EM Paradise, Eriko Takano, FC Lee, H Ikeda, I Thiele, J Gonzalez-Lergier, J Romero, J Schellenberger, JD Orth, JL Adrio, JP Brooks, JS Edwards, K Nieselt, K Yanai, LM Blank, M DeJongh, M Durot, M Kanehisa, M Latendresse, MA Fischbach, MA Oberhardt, MA Oberhardt, MA Oberhardt, Marnix H. Medema, MH Medema, MH Medema, MH Medema, MH Medema, MT Alam, MT Alam, MW Covert, N Scherr, ND Price, ND Price, NE Lewis, Piotr Zakrzewski, PR Ives, R Breitling, R Schuetz, Rainer Breitling, SA Becker, SD Bentley, Stephen S. Fong, TD Vo, TY Kim, XQ Zhao   +59 more
core   +6 more sources

Quantifying Dynamic Regulation in Metabolic Pathways with Nonparametric Flux Inference [PDF]

, 2019
One of the central tasks in systems biology is to understand how cells regulate their metabolism. Hierarchical regulation analysis is a powerful tool to study this regulation at the metabolic, gene-expression, and signaling levels.
He, Fei, Stumpf, Michael P H
core   +1 more source

The correlation between the central carbon metabolic flux distribution and the number of shared enzyme regulators in Saccharomyces cerevisiae

Brazilian Archives of Biology and Technology, 2016
The central carbon metabolic system is the upstream energy source for microbial fermentation. In addition, it is a master switch for increasing the production of metabolites and an important part of the microbial metabolic network. Investigation into the
Xiangfei Zhou, Lunxian Liu, Chuanyu Shang, Haifeng Xu, Chao Ding, Qian Liu, Yin Yi   +6 more
doaj   +1 more source

Organising metabolic networks: cycles in flux distributions [PDF]

, 2009
Metabolic networks are among the most widely studied biological systems. The topology and interconnections of metabolic reactions have been well described for many species, but are not sufficient to understand how their activity is regulated in living ...
Jean-Marc Schwartz, Marcelo T. dos Santos, Maurí, Sebastiá   +3 more
core   +2 more sources

Metabolic modeling and analysis of the metabolic switch in Streptomyces coelicolor [PDF]

, 2010
Background The transition from exponential to stationary phase in Streptomyces coelicolor is accompanied by a major metabolic switch and results in a strong activation of secondary metabolism.
Alam, Mohammad T., Breitling, Rainer, HASH(0x55aa09327868), Hodgson, D. A., Merlo, Maria E., Takano, Eriko, Wellington, E. M. H.   +6 more
core   +16 more sources

Fluxer: a web application to compute, analyze and visualize genome-scale metabolic flux networks

Nucleic Acids Res., 2020
Next-generation sequencing has paved the way for the reconstruction of genome-scale metabolic networks as a powerful tool for understanding metabolic circuits in any organism.
Archana Hari, Daniel Lobo
semanticscholar   +1 more source

Conservation of high-flux backbone in alternate optimal and near-optimal flux distributions of metabolic networks [PDF]

, 2008
Constraint-based flux balance analysis (FBA) has proven successful in predicting the flux distribution of metabolic networks in diverse environmental conditions. FBA finds one of the alternate optimal solutions that maximizes the biomass production rate.
Samal, Areejit
core   +3 more sources

Interplay between constraints, objectives, and optimality for genome-scale stoichiometric models.

PLoS Computational Biology, 2015
High-throughput data generation and genome-scale stoichiometric models have greatly facilitated the comprehensive study of metabolic networks. The computation of all feasible metabolic routes with these models, given stoichiometric, thermodynamic, and ...
Timo R Maarleveld, Meike T Wortel, Brett G Olivier, Bas Teusink, Frank J Bruggeman   +4 more
doaj   +1 more source