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Brain Endothelial Cells: Metabolic Flux and Energy Metabolism
2021The neurovascular unit (NVU) consists of multiple cell types including brain endothelial cells, pericytes, astrocytes, and neurons that function collectively to maintain homeostasis within the CNS microenvironment. As the principal barrier-forming component of the NVU, the endothelial cells perform an array of complex functions that require substantial
Cade J, McDonald +2 more
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Metabolomics, metabolic flux analysis and cancer pharmacology.
Pharmacology and Therapeutics, 2021Lingfan Liang +3 more
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Eukaryotic metabolism: Measuring compartment fluxes
Biotechnology Journal, 2011AbstractMetabolic compartmentation represents a major characteristic of eukaryotic cells. The analysis of compartmented metabolic networks is complicated by separation and parallelization of pathways, intracellular transport, and the need for regulatory systems to mediate communication between interdependent compartments.
Judith, Wahrheit +2 more
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Metabolic flux analysis and metabolic engineering of microorganisms
Mol. BioSyst., 2008Recent advances in metabolic flux analysis including genome-scale constraints-based flux analysis and its applications in metabolic engineering are reviewed. Various computational aspects of constraints-based flux analysis including genome-scale stoichiometric models, additional constraints used for the improved accuracy, and several algorithms for ...
Kim, Hyun Uk +2 more
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Toward Predicting Metabolic Fluxes in Metabolically Engineered Strains
Metabolic Engineering, 1999Predicting metabolic fluxes of a genetically engineered organism is an important step toward rational pathway design. However, because of various regulatory mechanisms, which are complex, often ill-characterized, and sometimes undiscovered, predicting metabolic fluxes using kinetic simulation is difficult.
J C, Liao, M K, Oh
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Amino Acid Metabolism and Fluxes
EcoSal Plus, 2008By the mid1960s, the pioneering work of Umbarger and Gerhart and Pardee had shown us that carbon flow through a biosynthetic pathway was controlled by allosteric inhibition of the first enzyme of the pathway by its end product; and, studies of the lac operon by Jacob and Monod had established that genes were ...
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1997
Abstract Flux analysis is a method of organizing data which shows the quantitative relationships among all the metabolic events going on in a fermentation. It is a simple description of what is actually happening in the fermentation and does not, in itself, consider the theory of how fermentations are limited or controlled.
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Abstract Flux analysis is a method of organizing data which shows the quantitative relationships among all the metabolic events going on in a fermentation. It is a simple description of what is actually happening in the fermentation and does not, in itself, consider the theory of how fermentations are limited or controlled.
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2014
Metabolic Flux Analysis: Methods and Protocols opens up the field of metabolic flux analysis to those who want to start a new flux analysis project but are overwhelmed by the complexity of the approach. Metabolic flux analysis emerged from the current limitation for the prediction of metabolic fluxes from a measured inventory of the cell.
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Metabolic Flux Analysis: Methods and Protocols opens up the field of metabolic flux analysis to those who want to start a new flux analysis project but are overwhelmed by the complexity of the approach. Metabolic flux analysis emerged from the current limitation for the prediction of metabolic fluxes from a measured inventory of the cell.
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Application of Metabolic Flux Analysis in Metabolic Engineering
2011Metabolic flux analysis (MFA) is an important analytical technique to quantify intracellular metabolic fluxes as a consequence of all catalytic and transcriptional interactions. In systems metabolic engineering, MFA has played important role to understand cellular physiology under particular conditions and predict its metabolic capability after genetic
Lee, SY Lee, Sang-Yup +2 more
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