Results 31 to 40 of about 2,439,575 (338)
Metabolites, 2021 Plant cell cultures derived from Taxus are used to produce valuable metabolites like paclitaxel, a chemotherapeutic drug. Methyl jasmonate elicitation enhances paclitaxel accumulation, but also inhibits culture growth and increases phenylpropanoid ...
Michelle C. McKee +2 more
doaj +1 more source
Nucleic Acids Research, 2019 Dynamic regulation is an effective strategy for fine-tuning metabolic pathways in order to maximize target product synthesis. However, achieving dynamic and autonomous up- and down-regulation of the metabolic modules of interest simultaneously, still ...
Yaokang Wu +9 more
semanticscholar +1 more source
Genetics, 1987 ABSTRACT Studies of Escherichia coli under competition for lactose in chemostat cultures have been used to determine the selective effects of variation in the level of the β-galactoside permease and the β-galactosidase enzyme. The results determine the adaptive topography of these gene products relative to growth in limiting lactose and ...
D E, Dykhuizen, A M, Dean, D L, Hartl
openaire +2 more sources
Light-based control of metabolic flux through assembly of synthetic organelles
Nature Chemical Biology, 2019 To maximize a desired product, metabolic engineers typically express enzymes to high, constant levels. Yet, permanent pathway activation can have undesirable consequences including competition with essential pathways and accumulation of toxic ...
Evan M. Zhao +7 more
semanticscholar +1 more source
Systems biology analysis of drivers underlying hallmarks of cancer cell metabolism. [PDF]
, 2017 Malignant transformation is often accompanied by significant metabolic changes. To identify drivers underlying these changes, we calculated metabolic flux states for the NCI60 cell line collection and correlated the variance between metabolic states of ...
Bordbar, Aarash +5 more
core +1 more source
Gluconeogenesis Flux in Metabolic Disease
Annual Review of Nutrition, 2023 Gluconeogenesis is a critical biosynthetic process that helps maintain whole-body glucose homeostasis and becomes altered in certain medical diseases. We review gluconeogenic flux in various medical diseases, including common metabolic disorders, hormonal imbalances, specific inborn genetic errors, and cancer.
Ankit, Shah, Fredric E, Wondisford
openaire +2 more sources
iScience, 2020 Summary: Cellular metabolism is dynamic, but quantifying non-steady metabolic fluxes by stable isotope tracers presents unique computational challenges.
Lake-Ee Quek +15 more
doaj +1 more source
Plants, 2022 Flavonoid biosynthesis requires the activities of several enzymes, which form weakly-bound, ordered protein complexes termed metabolons. To decipher flux regulation in the flavonoid biosynthetic pathway of chrysanthemum (Chrysanthemum morifolium Ramat ...
Sun-Hyung Lim +5 more
doaj +1 more source
Biology, 2023 Nutritional phosphate deficiency is a major limitation to plant growth. Here, we monitored fluxes in pathways supporting respiratory metabolism in potato (Solanum tuberosum) cell cultures growing in control or limiting phosphate conditions.
Jiang Zhou He +3 more
doaj +1 more source
Modular enzyme assembly for enhanced cascade biocatalysis and metabolic flux
Nature Communications, 2019 Enzymatic reactions in living cells are highly dynamic but simultaneously tightly regulated. Enzyme engineers seek to construct multienzyme complexes to prevent intermediate diffusion, to improve product yield, and to control the flux of metabolites ...
W. Kang +17 more
semanticscholar +1 more source