Results 41 to 50 of about 2,439,575 (338)

Transcriptional regulation is insufficient to explain substrate‐induced flux changes in Bacillus subtilis

Molecular Systems Biology, 2013
One of the key ways in which microbes are thought to regulate their metabolism is by modulating the availability of enzymes through transcriptional regulation.
Victor Chubukov, Markus Uhr, Ludovic Le Chat, Roelco J Kleijn, Matthieu Jules, Hannes Link, Stephane Aymerich, Jörg Stelling, Uwe Sauer   +8 more
doaj   +1 more source

Redirecting Metabolic Flux via Combinatorial Multiplex CRISPRi-Mediated Repression for Isopentenol Production in Escherichia coli.

ACS Synthetic Biology, 2019
CRISPR interference (CRISPRi) via target guide RNA (gRNA) arrays and a deactivated Cas9 (dCas9) protein has been shown to simultaneously repress expression of multiple genomic DNA loci.
Tian Tian, Jingwen Kang, A. Kang, T. Lee
semanticscholar   +1 more source

Computing the shortest elementary flux modes in genome-scale metabolic networks [PDF]

, 2009
This article is available open access through the publisher’s website through the link below. Copyright @ The Author 2009.Motivation: Elementary flux modes (EFMs) represent a key concept to analyze metabolic networks from a pathway-oriented perspective ...
Acuña, Adam Podhorski, Angel Rubio, Beasley, Blattner, Christoph Kaleta, Cohen, Dandekar, de Graaf, Eggeling, Eggeling, Feist, Fell, Fischer, Francisco J. Planes, Gagneur, Inui, John E. Beasley, Kacser, Kaleta, Kalinowski, Kjeldsen, Klamt, Klamt, Klamt, Koch, Liao, Luis F. de Figueiredo, Mavrovouniotis, Meléndez-Hevia, Molin, Niederberger, Pardalos, Pfeiffer, Planes, Price, Schilling, Schuster, Schuster, Schuster, Schuster, Schuster, Schwarz, Stefan Schuster, Subedi, Terzer, Teusink, Tosaka, Trinh, Vallino, van Winden, von Kamp, Wendisch, Wittmann, Yuan   +54 more
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Structural Control of Metabolic Flux

PLoS Computational Biology, 2013
Organisms have to continuously adapt to changing environmental conditions or undergo developmental transitions. To meet the accompanying change in metabolic demands, the molecular mechanisms of adaptation involve concerted interactions which ultimately induce a modification of the metabolic state, which is characterized by reaction fluxes and ...
Sajitz-Hermstein, M., Nikoloski, Z.
openaire   +5 more sources

Metabolic regulation of regulatory T cell development and function [PDF]

, 2014
It is now well established that the effector T cell (Teff) response is regulated by a series of metabolic switches. Quiescent T cells predominantly require ATP-generating processes, whereas proliferating Teff require high metabolic flux through growth ...
Alves, Barbi, Battaglia, Bental, Borsellino, Carr, Cipolletta, Cobbold, Coloff, Cunningham, Curti, Cybulski, Dang, Deiuliis, Delgoffe, Delgoffe, Feuerer, Fisson, Fox, Frauwirth, GabryÅ¡ová, Greiner, Guertin, Guertin, Gulen, Hardie, Hardie, Howie, Hörig, Jacobs, Jones, Jordan, Kane, Lee, Lord, Makki, Matarese, Matteoli, Mellor, Metz, Michalek, Munder, Munder, Oh, Olefsky, Ouchi, Peter, Powell, Powell, Powell, Powell, Procaccini, Procaccini, Sakaguchi, Sarbassov, Shevach, Shi, Sitkovsky, Smith, Thornton, Vanasek, Vander Heiden, Vukmanovic-Stejic, Waickman, Wieman, Winer, Yang, Zeng, Zheng   +68 more
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Regulation of yeast central metabolism by enzyme phosphorylation

Molecular Systems Biology, 2012
As a frequent post‐translational modification, protein phosphorylation regulates many cellular processes. Although several hundred phosphorylation sites have been mapped to metabolic enzymes in Saccharomyces cerevisiae, functionality was demonstrated for
Ana Paula Oliveira, Christina Ludwig, Paola Picotti, Maria Kogadeeva, Ruedi Aebersold, Uwe Sauer   +5 more
doaj   +1 more source

Calcium Carbonate Addition Improves L-Methionine Biosynthesis by Metabolically Engineered Escherichia coli W3110-BL

Frontiers in Bioengineering and Biotechnology, 2020
L-Methionine (L-Met) is a sulfur-containing amino acid, which is one of the eight essential amino acids to human body. In this work, the fermentative production of L-Met with genetically engineered Escherichia coli W3110-BL in a 5-L fermentor was ...
Hai-Yan Zhou, Hai-Yan Zhou, Hai-Yan Zhou, Wang-Jie Wu, Wang-Jie Wu, Wang-Jie Wu, Yue-Ying Xu, Yue-Ying Xu, Yue-Ying Xu, Bin Zhou, Bin Zhou, Bin Zhou, Kun Niu, Kun Niu, Kun Niu, Zhi-Qiang Liu, Zhi-Qiang Liu, Zhi-Qiang Liu, Yu-Guo Zheng, Yu-Guo Zheng, Yu-Guo Zheng   +20 more
doaj   +1 more source

Phosphofructokinase 1 Glycosylation Regulates Cell Growth and Metabolism [PDF]

, 2012
Cancer cells must satisfy the metabolic demands of rapid cell growth within a continually changing microenvironment. We demonstrated that the dynamic posttranslational modification of proteins by O-linked β-N-acetylglucosamine (O-GlcNAcylation) is a key ...
Clark, Peter M., Driggers, Edward M., Goddard, William A., III, Hill, Collin, Hsieh-Wilson, Linda C., Keenan, Marie C., Mason, Daniel E., Peters, Eric C., Yi, Wen   +8 more
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A guide to 13C metabolic flux analysis for the cancer biologist

Experimental and Molecular Medicine, 2018
Cancer metabolism is significantly altered from normal cellular metabolism allowing cancer cells to adapt to changing microenvironments and maintain high rates of proliferation.
M. Antoniewicz
semanticscholar   +1 more source

Metabolic Fluxes and Stoichiometry of Glucose Metabolism [PDF]

Biophysical Journal, 2008
I would like to comment on a recent article by Bertram et al. titled “Interaction of Glycolysis and Mitochondrial Respiration in Metabolic Oscillations of Pancreatic Islets”(1xInteraction of glycolysis and mitochondrial respiration in metabolic oscillations of pancreatic islets.
openaire   +2 more sources