Results 51 to 60 of about 2,439,575 (338)
Thermodynamics-Based Metabolic Flux Analysis [PDF]
Biophysical Journal, 2007 A new form of metabolic flux analysis (MFA) called thermodynamics-based metabolic flux analysis (TMFA) is introduced with the capability of generating thermodynamically feasible flux and metabolite activity profiles on a genome scale. TMFA involves the use of a set of linear thermodynamic constraints in addition to the mass balance constraints ...
Henry, Christopher S. +2 more
openaire +2 more sources
The protein cost of metabolic fluxes: prediction from enzymatic rate laws and cost minimization
, 2016 Bacterial growth depends crucially on metabolic fluxes, which are limited by the cell's capacity to maintain metabolic enzymes. The necessary enzyme amount per unit flux is a major determinant of metabolic strategies both in evolution and bioengineering.
Bar-Even, Arren +5 more
core +6 more sources
Micro-Slab Coil Design for Hyperpolarized Metabolic Flux Analysis in Multiple Samples
Bioengineering, 2022 Abnormal metabolism is a hallmark of cancer cells. Accumulating evidence suggests that metabolic changes are likely to occur before other cellular responses in cancer cells upon drug treatment.
Geonhui Lee +7 more
doaj +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance Efficient microbial synthesis in challenging pathways relies on dynamic regulation of multiple metabolic fluxes to balance several competing goals.
C. V. Dinh, K. Prather
semanticscholar +1 more source
A functional analysis of 180 cancer cell lines reveals conserved intrinsic metabolic programs
Molecular Systems Biology, 2022 Cancer cells reprogram their metabolism to support growth and invasion. While previous work has highlighted how single altered reactions and pathways can drive tumorigenesis, it remains unclear how individual changes propagate at the network level and ...
Sarah Cherkaoui +10 more
doaj +1 more source
Chaperonin Abundance Enhances Bacterial Fitness
Frontiers in Molecular Biosciences, 2021 The ability of chaperonins to buffer mutations that affect protein folding pathways suggests that their abundance should be evolutionarily advantageous. Here, we investigate the effect of chaperonin overproduction on cellular fitness in Escherichia coli.
C. M. Santosh Kumar +7 more
doaj +1 more source
Nature Communications, 2019 Genetic diversity is a result of evolution, enabling multiple ways for one particular physiological activity. Here, we introduce this strategy into bioengineering. We design two hydroxytyrosol biosynthetic pathways using tyrosine as substrate.
Wei Chen +10 more
semanticscholar +1 more source
Analysis of metabolic flux using dynamic labeling and metabolic modeling [PDF]
, 2013 Metabolic fluxes and the capacity to modulate them are a crucial component of the ability of the plant cell to react to environmental perturbations. Our ability to quantify them and to attain information concerning the regulatory mechanisms which control
Fernie, A., Morgan, J.
core +2 more sources
PLoS ONE, 2015 Sampling the solution space of genome-scale models is generally conducted to determine the feasible region for metabolic flux distribution. Because the region for actual metabolic states resides only in a small fraction of the entire space, it is ...
Baofang Chi, Shiheng Tao, Yanlin Liu
doaj +1 more source
Journal of Agricultural and Food Chemistry, 2019 Ginkgo biloba is a monotypic species native to China with great economic and ecological values. Leaves extract of this tree contains about 24% flavonoids, which are widely used in the pharmaceutical industry.
Jie Meng +9 more
semanticscholar +1 more source