Results 11 to 20 of about 450,408 (297)
Extended Metabolic Space Modeling [PDF]
, 2018 Determining the fraction of the chemical space that can be processed in vivo by using natural and synthetic biology devices is crucial for the development of advanced synthetic biology applications. The extended metabolic space is a coding system based on molecular signatures that enables the derivation of reaction rules for metabolic reactions and the
Carbonell, Pablo +2 more
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, 2022 Oncogene-driven metabolic rewiring in cancer is key to allow proliferation of tumour cells in low nutrient and oxygen conditions. To study such phenomena, reconstructing context-specific metabolic models through omics data integration is crucial. Here we report the original pipeline to construct context-specific metabolic models from scRNA-seq data and
Petrizzelli, Marianyela +3 more
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Structural Kinetic Modeling of Metabolic Networks [PDF]
, 2006 To develop and investigate detailed mathematical models of cellular metabolic processes is one of the primary challenges in systems biology. However, despite considerable advance in the topological analysis of metabolic networks, explicit kinetic ...
B. Blasius +19 more
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Frontiers in Plant Science, 2018 Experimental high-throughput analysis of molecular networks is a central approach to characterize the adaptation of plant metabolism to the environment.
Matthias Nagler +11 more
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Obese patients with a binge eating disorder have an unfavorable metabolic and inflammatory profile [PDF]
, 2015 To evaluate whether obese patients with a binge eating disorder (BED) have an altered metabolic and inflammatory profile related to their eating behaviors compared with non-BED obese.A total of 115 White obese patients consecutively recruited underwent ...
Aloi, M +8 more
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Augmenting Biogas Process Modeling by Resolving Intracellular Metabolic Activity [PDF]
, 2019 The process of anaerobic digestion in which waste biomass is transformed to methane by complex microbial communities has been modeled for more than 16 years by parametric gray box approaches that simplify process biology and do not resolve intracellular ...
Denny Popp +7 more
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Impact of stoichiometry representation on simulation of genotype-phenotype relationships in metabolic networks. [PDF]
, 2012 Genome-scale metabolic networks provide a comprehensive structural framework for modeling genotype-phenotype relationships through flux simulations. The solution space for the metabolic flux state of the cell is typically very large and optimization ...
a Becker S +39 more
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From Next-Generation Sequencing to Systematic Modeling of the Gut Microbiome
Frontiers in Genetics, 2015 Changes in the human gut microbiome is associated with altered human metabolism and health, yet the mechanisms of interactions between microbial species and human metabolism have not been clearly elucidated.
Boyang eJi, Jens eNielsen
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mBio, 2021 There is considerable interest in promoting biological nitrogen fixation (BNF) as a mechanism to reduce the inputs of nitrogenous fertilizers in agriculture, but considerable fundamental knowledge gaps still need to be addressed.
Alexander B. Alleman +2 more
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Applications of metabolic modelling to plant metabolism [PDF]
Journal of Experimental Botany, 2004 In this paper some of the general concepts underpinning the computer modelling of metabolic systems are introduced. The difference between kinetic and structural modelling is emphasized, and the more important techniques from both, along with the physiological implications, are described.
M G, Poolman, H E, Assmus, D A, Fell
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