Results 51 to 60 of about 450,408 (297)

Changes in Body Composition in Children and Young People Undergoing Treatment for Acute Lymphoblastic Leukemia: A Systematic Review and Meta‐Analysis

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Ongoing evidence indicates increased risk of sarcopenic obesity among children and young people (CYP) with acute lymphoblastic leukemia (ALL), often beginning early in treatment, persisting into survivorship. This review evaluates current literature on body composition in CYP with ALL during and after treatment.
Lina A. Zahed   +5 more
wiley   +1 more source

Understanding the causes and implications of endothelial metabolic variation in cardiovascular disease through genome scale metabolic modeling

open access: yesFrontiers in Cardiovascular Medicine, 2016
High-throughput biochemical profiling has led to a requirement for advanced data interpretation techniques capable of integrating the analysis of gene, protein, and metabolic profiles to shed light on genotype-phenotype relationships. Herein, we consider
Sarah eMcGarrity   +5 more
doaj   +1 more source

Current Challenges in Modeling Cellular Metabolism [PDF]

open access: yes, 2016
Mathematical and computational models play an essential role in understanding the cellular metabolism. They are used as platforms to integrate current knowledge on a biological system and to systematically test and predict the effect of manipulations to ...

core   +1 more source

Metabolic regulation and mathematical models

open access: yesProgress in Biophysics and Molecular Biology, 1978
Publisher Summary This chapter discusses the study of the regulation of metabolism by mathematical models. There has grown a sizable literature on the theoretical analysis of biological regulation, mostly by means of mathematical models. Modeling is an advanced technique for the study of the regulation.
R, Heinrich   +2 more
openaire   +2 more sources

A Comparative Study of Cerebral Oxygenation During Exercise in Hemodialysis and Peritoneal Dialysis Patients

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Cognitive impairment and exercise intolerance are common in dialysis patients. Cerebral perfusion and oxygenation play a major role in both cognitive function and exercise execution; HD session per se aggravates cerebral ischemia in this population. This study aimed to compare cerebral oxygenation and perfusion at rest and in mild
Marieta P. Theodorakopoulou   +10 more
wiley   +1 more source

Genomewide Assessment of Mycobacterium tuberculosis Conditionally Essential Metabolic Pathways

open access: yesmSystems, 2019
A better understanding of essential cellular functions in pathogenic bacteria is important for the development of more effective antimicrobial agents. We performed a comprehensive identification of essential genes in Mycobacterium tuberculosis, the major
Yusuke Minato   +6 more
doaj   +1 more source

A systematic overexpression approach reveals native targets to increase squalene production in Synechocystis sp. PCC 6803

open access: yesFrontiers in Plant Science, 2023
Cyanobacteria are a promising platform for the production of the triterpene squalene (C30), a precursor for all plant and animal sterols, and a highly attractive intermediate towards triterpenoids, a large group of secondary plant metabolites ...
Anna T. Germann   +7 more
doaj   +1 more source

Physiological modeling of isoprene dynamics in exhaled breath [PDF]

open access: yes, 2003
Human breath contains a myriad of endogenous volatile organic compounds (VOCs) which are reflective of ongoing metabolic or physiological processes.
King, Julian   +8 more
core   +4 more sources

Adaptations of Escherichia coli strains to oxidative stress are reflected in properties of their structural proteomes. [PDF]

open access: yes, 2020
BACKGROUND:The reconstruction of metabolic networks and the three-dimensional coverage of protein structures have reached the genome-scale in the widely studied Escherichia coli K-12 MG1655 strain.
Catoiu, Edward   +6 more
core   +2 more sources

Mapping the evolution of mitochondrial complex I through structural variation

open access: yesFEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin   +2 more
wiley   +1 more source

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