Results 61 to 70 of about 450,408 (297)
Metabolites, 2023 Recent advancements in omics technologies have generated a wealth of biological data. Integrating these data within mathematical models is essential to fully leverage their potential.
Partho Sen, Matej Orešič
doaj +1 more source
Modelling Worldviews as Stable Metabolisms
Entropy, 2022 The emergence and evolution of worldviews is a complex phenomenon that requires strong and rigorous scientific attention in our hyperconnected world. On the one hand, cognitive theories have proposed reasonable frameworks but have not reached general modeling frameworks where predictions can be tested.
Tomas Veloz, Pedro Maldonado
openaire +4 more sources
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Genome-driven evolutionary game theory helps understand the rise of metabolic interdependencies in microbial communities [PDF]
, 2017 Metabolite exchanges in microbial communities give rise to ecological interactions that govern ecosystem diversity and stability. It is unclear, however, how the rise of these interactions varies across metabolites and organisms.
Segre, Daniel, Zomorrodi, Ali R.
core +2 more sources
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Lung Circulation Modeling: Status and Prospect [PDF]
, 2006 Mathematical modeling has been used to interpret anatomical and physiological data obtained from metabolic and hemodynamic studies aimed at investigating structure-function relationships in the vasculature of the lung, and how these relationships are ...
Audi, Said H. +3 more
core +1 more source
The Dynamics of Hybrid Metabolic-Genetic Oscillators [PDF]
, 2013 The synthetic construction of intracellular circuits is frequently hindered by a poor knowledge of appropriate kinetics and precise rate parameters. Here, we use generalized modeling (GM) to study the dynamical behavior of topological models of a family ...
Alon U. +5 more
core +1 more source
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Comment on "Regularizing capacity of metabolic networks"
, 2008 In a recent paper, Marr, Muller-Linow and Hutt [Phys. Rev. E 75, 041917 (2007)] investigate an artificial dynamic system on metabolic networks. They find a less complex time evolution of this dynamic system in real networks, compared to networks of ...
A. Wagner +4 more
core +1 more source
Software that goes with the flow in systems biology [PDF]
, 2010 A recent article in BMC Bioinformatics describes new advances in workflow systems for computational modeling in systems biology. Such systems can accelerate, and improve the consistency of, modeling through automation not only at the simulation and ...
A Funahashi +14 more
core +3 more sources