Results 71 to 80 of about 450,408 (297)

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Clostridioides difficile-mucus interactions encompass shifts in gene expression, metabolism, and biofilm formation

mSphere
In a healthy colon, the stratified mucus layer serves as a crucial innate immune barrier to protect the epithelium from microbes. Mucins are complex glycoproteins that serve as a nutrient source for resident microflora and can be exploited by pathogens ...
Kathleen L. Furtado, Lucas Plott, Matthew Markovetz, Deborah Powers, Hao Wang, David B. Hill, Jason Papin, Nancy L. Allbritton, Rita Tamayo   +8 more
doaj   +1 more source

Topological Analysis of the Carbon-Concentrating CETCH Cycle and a Photorespiratory Bypass Reveals Boosted CO2-Sequestration by Plants

Frontiers in Bioengineering and Biotechnology, 2021
Synthetically designed alternative photorespiratory pathways increase the biomass of tobacco and rice plants. Likewise, some in planta–tested synthetic carbon-concentrating cycles (CCCs) hold promise to increase plant biomass while diminishing ...
Özge Osmanoglu, Mariam Khaled AlSeiari, Hasa Abduljaleel AlKhoori, Shabana Shams, Elena Bencurova, Thomas Dandekar, Muhammad Naseem, Muhammad Naseem   +7 more
doaj   +1 more source

Quantitative constraint-based computational model of tumor-to-stroma coupling via lactate shuttle [PDF]

, 2015
Cancer cells utilize large amounts of ATP to sustain growth, relying primarily on non-oxidative, fermentative pathways for its production.
CAPUANI, FABRIZIO, DE MARTINO, ANDREA, DE MARTINO, DANIELE, MARINARI, Vincenzo   +3 more
core   +1 more source

Mathematical models of plant metabolism [PDF]

Current Opinion in Biotechnology, 2016
Among various modeling approaches in plant metabolic research, applications of Constraint-Based modeling are fast increasing in recent years, apparently driven by current advances in genomics and genome sequencing. Constraint-Based modeling, the functional analysis of metabolic networks at the whole cell or genome scale, is more difficult to apply to ...
Hai, Shi, Jörg, Schwender
openaire   +2 more sources

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

A genome-scale metabolic model of a globally disseminated hyperinvasive M1 strain of Streptococcus pyogenes

mSystems
Streptococcus pyogenes is responsible for a range of diseases in humans contributing significantly to morbidity and mortality. Among more than 200 serotypes of S.
Yujiro Hirose, Daniel C. Zielinski, Saugat Poudel, Kevin Rychel, Jonathon L. Baker, Yoshihiro Toya, Masaya Yamaguchi, Almut Heinken, Ines Thiele, Shigetada Kawabata, Bernhard O. Palsson, Victor Nizet   +11 more
doaj   +1 more source

Nonalcoholic Fatty Liver Disease and Endocrine Axes—A Scoping Review

Metabolites, 2022
Nonalcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease. NAFLD often occurs associated with endocrinopathies. Evidence suggests that endocrine dysfunction may play an important role in NAFLD development, progression, and ...
Madalena Von-Hafe, Marta Borges-Canha, Catarina Vale, Ana Rita Leite, João Sérgio Neves, Davide Carvalho, Adelino Leite-Moreira   +6 more
doaj   +1 more source

Reconstruction of an in silico metabolic model of _Arabidopsis thaliana_ through database integration [PDF]

, 2009
The number of genome-scale metabolic models has been rising quickly in recent years, and the scope of their utilization encompasses a broad range of applications from metabolic engineering to biological discovery.
Albert Gevorgyan, Jean-Marc Schwartz, Karin Radrich, Neil Swainston, Paul Dobson, Yoshimasa Tsuruoka   +5 more
core   +1 more source

Strong associations between microbe phenotypes and their network architecture

, 2009
Understanding the dependence and interplay between architecture and function in biological networks has great relevance to disease progression, biological fabrication and biological systems in general.
G. Schlosser, Soumen Roy, Vladimir Filkov   +2 more
core   +1 more source