Results 81 to 90 of about 335,580 (367)
Chemical Transformation Motifs - Modelling Pathways as Integer Hyperflows
, 2017 We present an elaborate framework for formally modelling pathways in chemical reaction networks on a mechanistic level. Networks are modelled mathematically as directed multi-hypergraphs, with vertices corresponding to molecules and hyperedges to ...
Andersen, Jakob L. +3 more
core +1 more source
A genome scale metabolic network for rice and accompanying analysis of tryptophan, auxin and serotonin biosynthesis regulation under biotic stress [PDF]
, 2013 Background Functional annotations of large plant genome projects mostly provide information on gene function and gene families based on the presence of protein domains and gene homology, but not necessarily in association with gene expression or ...
Amarasinghe, V. +8 more
core +2 more sources
Flux-dependent graphs for metabolic networks
npj Systems Biology and Applications, 2016 Cells adapt their metabolic fluxes in response to changes in the environment. We present a framework for the systematic construction of flux-based graphs derived from organism-wide metabolic networks.
Mariano Beguerisse-Díaz +4 more
semanticscholar +1 more source
, 2012 Unraveling the structure of complex biological networks and relating it to their functional role is an important task in systems biology. Here we attempt to characterize the functional organization of the large-scale metabolic networks of three ...
Giri, Varun +5 more
core +2 more sources
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Organellar carbon metabolism is co-ordinated with distinct developmental phases of secondary xylem [PDF]
, 2019 Subcellular compartmentation of plant biosynthetic pathways in the mitochondria and plastids requires coordinated regulation of nuclear encoded genes, and the role of these genes has been largely ignored by wood researchers. In this study, we constructed
Fierro Gutierrez, Ana Carolina Elisa +4 more
core +2 more sources
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
Genome-Wide Association Study of Metabolic Syndrome in Koreans [PDF]
Genomics & Informatics, 2014 Metabolic syndrome (METS) is a disorder of energy utilization and storage and increases the risk of developing cardiovascular disease and diabetes. To identify the genetic risk factors of METS, we carried out a genome-wide association study (GWAS) for 2 ...
Seok Won Jeong +4 more
doaj +1 more source
Nucleic Acids Res., 2015 MetaNetX is a repository of genome-scale metabolic networks (GSMNs) and biochemical pathways from a number of major resources imported into a common namespace of chemical compounds, reactions, cellular compartments—namely MNXref—and proteins.
S. Moretti +7 more
semanticscholar +1 more source
Toolbox model of evolution of prokaryotic metabolic networks and their regulation [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2009 It has been reported that the number of transcription factors encoded in prokaryotic genomes scales approximately quadratically with their total number of genes.
S. Maslov +3 more
semanticscholar +1 more source