Results 11 to 20 of about 1,447,822 (302)

Metabolic pathway engineering

Synthetic and Systems Biotechnology, 2018
Hal S. Alper
doaj   +3 more sources

METABOLIC PATHWAYS [PDF]

Neuro-Oncology, 2013
The kynurenine pathway (KP) is the principal route of L-Tryptophan (TRP) catabolism leading to the production of kynurenine (KYN), the neuroprotectants, kynurenic acid (KYNA) and picolinic acid (PIC), and the excitotoxic neurotoxin, quinolinic acid (QUIN).
S. Adams, C. Teo, K. McDonald, A. Zinger, S. Bustamante, C. K. Lim, N. Braidy, B. J. Brew, G. J. Guillemin, S. Agnihotri, K. Burrell, S. Singh, A. Vartanian, A. Wolf, F. Lang, R. Verhaak, C. Hawkins, K. Aldape, G. Zadeh, C. Chesnelong, M. Chaumeil, M. D. Blough, M. Al-Najjar, O. D. Stechishin, S. Ronen, S. Weiss, H. A. Luchman, J. G. Cairncross, E. Fonkem, R. Tobin, J. Griffin, A. Zuzek, M. Rogers, M. Giladi, Y. Wasserman, N. Urman, Y. Porat, R. Schneiderman, M. Munster, U. Weinberg, E. Kirson, Y. Palti, J. Godlewski, A. Bronisz, K. Ansari, D. Ogawa, M. O. Nowicki, E. A. Chiocca, A. Kathagen, A. Schulte, G. Balcke, H. Phillips, H. Gunther, M. Westphal, K. Lamszus, K. Makino, H. Nakamura, T.-i. Hide, S. Yano, J.-i. Kuroda, J.-i. Kuratsu, F. Fack, D. Bonnel, G. Hochart, A. C. Navis, P. Wesseling, W. P. J. Leenders, J. Stauber, S. P. Niclou, F. Sahm, I. Oezen, C. Opitz, B. Radlwimmer, A. von Deimling, H. B. Bode, T. Ahrendt, S. Adams, G. Guillemin, W. Wick, M. Platten, D. Schonberg, D. Lubelski, J. Rich, A. Vartanian, S. K. Singh, K. Burrell, S. Agnihotri, N. Sabha, G. Zadeh   +88 more
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Astrocyte metabolism and signaling pathways in the CNS

Frontiers in Neuroscience, 2023
Astrocytes comprise half of the cells in the central nervous system and play a critical role in maintaining metabolic homeostasis. Metabolic dysfunction in astrocytes has been indicated as the primary cause of neurological diseases, such as depression ...
Yong-mei Zhang, Yong-mei Zhang, Yong-mei Zhang, Ying-bei Qi, Ying-bei Qi, Ying-bei Qi, Ya-nan Gao, Ya-nan Gao, Wen-gang Chen, Wen-gang Chen, Ting Zhou, Ting Zhou, Yi Zang, Yi Zang, Jia Li, Jia Li, Jia Li, Jia Li   +17 more
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The landscape of metabolic pathway dependencies in cancer cell lines.

PLoS Computational Biology, 2021
The metabolic reprogramming of cancer cells creates metabolic vulnerabilities that can be therapeutically targeted. However, our understanding of metabolic dependencies and the pathway crosstalk that creates these vulnerabilities in cancer cells remains ...
James H Joly, Brandon T L Chew, Nicholas A Graham   +2 more
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Metabolomics Analysis of Lettuce (Lactuca sativa L.) Affected by Low Potassium Supply

Agriculture, 2022
Lettuce is a commercially significant leafy vegetable worldwide. Potassium (K) is an essential macronutrient for lettuce growth and development and significantly impacts its metabolites.
Hongyan Gao, Liyan Gong, Jiheng Ni, Qinglin Li   +3 more
doaj   +1 more source

Metabolism and toxicity of usnic acid and barbatic acid based on microsomes, S9 fraction, and 3T3 fibroblasts in vitro combined with a UPLC-Q-TOF-MS method

Frontiers in Pharmacology, 2023
Introduction: Usnic acid (UA) and barbatic acid (BA), two typical dibenzofurans and depsides in lichen, have a wide range of pharmacological activities and hepatotoxicity concerns.
Hanxue Wang, Hanxue Wang, Hanxue Wang, Min Xuan, Juanjuan Diao, Nan Xu, Manlin Li, Cheng Huang, Changhong Wang   +8 more
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Isoprene oxidation by the gram-negative model bacterium variovorax sp. WS11 [PDF]

, 2020
Plant-produced isoprene (2-methyl-1,3-butadiene) represents a significant portion of global volatile organic compound production, equaled only by methane.
Crombie, Andrew T., Dawson, Robin A., Larke-Mejía, Nasmille L., Murrell, J. Colin, Ul Haque, Muhammad Farhan   +4 more
core   +1 more source

Branch point control at malonyl-CoA node: A computational framework to uncover the design principles of an ideal genetic-metabolic switch

Metabolic Engineering Communications, 2020
Living organism is an intelligent system coded by hierarchically-organized information to perform precisely-controlled biological functions. Biophysical models are important tools to uncover the design rules underlying complex genetic-metabolic circuit ...
Peng Xu
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Application of HPLC and ESI-MS techniques in the analysis of phenolic acids and flavonoids from green leafy vegetables (GLVs)

Journal of Pharmaceutical Analysis, 2017
Diets containing high proportions of fruits and vegetables reduce the risk of onset of chronic diseases. The role of herbal medicines in improving human health is gaining popularity over the years, which also increases the need for safety and efficiency ...
B. Ramesh Kumar
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NMR-Based Metabolomics to Analyze the Effects of a Series of Monoamine Oxidases-B Inhibitors on U251 Cells

Biomolecules, 2023
Alzheimer’s disease (AD) is a typical progressive neurodegenerative disorder, and with multiple possible pathogenesis. Among them, coumarin derivatives could be used as potential drugs as monoamine oxidase-B (MAO-B) inhibitors.
Zili Guo, Jinping Gu, Miao Zhang, Feng Su, Weike Su, Yuanyuan Xie   +5 more
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