Results 21 to 30 of about 1,447,822 (302)
Activation of the Amino Acid Response Pathway Blunts the Effects of Cardiac Stress
Background The amino acid response (AAR) is an evolutionarily conserved protective mechanism activated by amino acid deficiency through a key kinase, general control nonderepressible 2.
Pu Qin +31 more
doaj +1 more source
Elementary vectors and conformal sums in polyhedral geometry and their relevance for metabolic pathway analysis [PDF]
A fundamental result in metabolic pathway analysis states that every flux mode can be decomposed into a sum of elementary modes. However, only a decomposition without cancelations is biochemically meaningful, since a reversible reaction cannot have ...
Müller, Stefan, Regensburger, Georg
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Germination and processing are always accompanied by significant changes in the metabolic compositions of rice. In this study, polished rice (rice), brown rice, wet germinated brown rice (WGBR), high temperature and pressure-treated WGBR (WGBR-HTP), and ...
Chuan-ying REN +8 more
doaj +1 more source
Quantifying Dynamic Regulation in Metabolic Pathways with Nonparametric Flux Inference [PDF]
One of the central tasks in systems biology is to understand how cells regulate their metabolism. Hierarchical regulation analysis is a powerful tool to study this regulation at the metabolic, gene-expression, and signaling levels.
He, Fei, Stumpf, Michael P H
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C2–C4 diols classically derived from fossil resource are very important bulk chemicals which have been used in a wide range of areas, including solvents, fuels, polymers, cosmetics, and pharmaceuticals.
Ye Zhang, Dehua Liu, Zhen Chen
doaj +1 more source
Phosphofructokinase 1 Glycosylation Regulates Cell Growth and Metabolism [PDF]
Cancer cells must satisfy the metabolic demands of rapid cell growth within a continually changing microenvironment. We demonstrated that the dynamic posttranslational modification of proteins by O-linked β-N-acetylglucosamine (O-GlcNAcylation) is a key ...
Clark, Peter M. +8 more
core +2 more sources
Kinetics and New Mechanism of Azoxystrobin Biodegradation by an Ochrobactrum anthropi Strain SH14
Azoxystrobin is one of the most popular strobilurin fungicides, widely used in agricultural fields for decades.Extensive use of azoxystrobin poses a major threat to ecosystems.
Yanmei Feng +7 more
doaj +1 more source
Metabolic Modulation Predicts Heart Failure Tests Performance [PDF]
The metabolic changes that accompany changes in Cardiopulmonary testing (CPET) and heart failure biomarkers (HFbio) are not well known. We undertook metabolomic and lipidomic phenotyping of a cohort of heart failure (HF) patients and utilized Multiple ...
Abbate, Antonio +11 more
core +3 more sources
Aberrant metabolism is one of the main driving forces in the initiation and development of ESCC. Both genes and metabolites play important roles in metabolic pathways. Integrative pathway analysis of both genes and metabolites will thus help to interpret
Chunquan Li +6 more
doaj +1 more source
Improving clustering with metabolic pathway data [PDF]
Background: It is a common practice in bioinformatics to validate each group returned by a clustering algorithm through manual analysis, according to a-priori biological knowledge.
Carrari, Fernando Oscar +4 more
core +2 more sources

