Results 31 to 40 of about 972,456 (315)

Exploring metabolic pathway disruption in the subchronic phencyclidine model of schizophrenia with the generalized singular value decomposition [PDF]

, 2011
The quantification of experimentally-induced alterations in biological pathways remains a major challenge in systems biology. One example of this is the quantitative characterization of alterations in defined, established metabolic pathways from complex ...
Dawson, Neil, Xiaolin Xiao, Brian J Morris, Xiao, X., Higham, Desmond, MacIntyre, L., Pratt, J.A., Morris, Brian J., MacIntyre, Lynsey, Higham, Desmond J, Higham, D.J., Desmond J Higham, Watson, David, Neil Dawson, Watson, David G., Judith A Pratt, Xiao, Xiaolin, Morris, B.J., Pratt, Judith, David G Watson, Pratt, Judith A., Dawson, N., Lynsey MacIntyre, Watson, D.G., Morris, Brian   +24 more
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Restoring a Metabolic Pathway [PDF]

ACS Chemical Biology, 2008
Gluconeogenesis is blocked in a strain of Escherichia coli that is deficient in triosephosphate isomerase, but it was restored by the insertion of a plasmid coding for an L-glyceraldehyde 3-phosphate reductase (YghZ). This reductase provides a "bypass" that produces dihydroxyacetone phosphate (DHAP) by the consecutive enzyme-catalyzed reduction of L ...
openaire   +2 more sources

Design of robust metabolic pathways [PDF]

Proceedings of the 48th Design Automation Conference, 2011
In this paper we investigate plant photosynthesis and microbial fuel cells. We report the following: 1) we introduce and validate a novel multi-objective optimization algorithm, PMO2; 2) in photosynthesis we increase the yield of 135%, while in Geobacter sulfurreducens we determine the tradeoff for growth versus redox properties; 3) finally, we discuss
Renato Umeton, Giovanni Stracquadanio, Anilkumar Sorathiya, Pietro Liò, Alessio Papini, Giuseppe Nicosia   +5 more
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The Donor-Dependent and Colon-Region-Dependent Metabolism of (+)-Catechin by Colonic Microbiota in the Simulator of the Human Intestinal Microbial Ecosystem

Molecules, 2021
The intestinal absorption of dietary catechins is quite low, resulting in most of them being metabolized by gut microbiota in the colon. It has been hypothesized that microbiota-derived metabolites may be partly responsible for the association between ...
Qiqiong Li, Florence Van Herreweghen, Marjan De Mey, Geert Goeminne, Tom Van de Wiele   +4 more
doaj   +1 more source

TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei. [PDF]

, 2014
The metabolic network of a cell represents the catabolic and anabolic reactions that interconvert small molecules (metabolites) through the activity of enzymes, transporters and non-catalyzed chemical reactions.
Opperdoes, F.R. (Fred), van Hellemond, JJ, de Koning, HP, Nes, D. W.,, Nayak, A.,, Silva-Franco, F.,, de, Koning HP, Wyllie, S, Ebikeme, C., van Hellemond, Jaap; id_orcid, van Hellemond, J. J.,, Crouch, Kathryn, Ferguson, Michael A.J., Nolan, D. P.,, Bütikofer, P. (Peter), Nolan, Derek P., Barrett, Michael P, Ebikeme, C. (Charles), Olsen, C, De Koning, H.P. (Harry P.), Jourdan, F., Vinson, F. (Florence), Bütikofer, P, Ferguson, MA, Ferguson, Michael A. J., Mäser, P, Butikofer, P., Opperdoes, F. R., Breitling, R., Nayak, A, Achcar, F., Smith, Terry K., Ferguson, MAJ, Boshart, M., Boshart, M, Denise, H., Logan-Klumpler, F. J.,, Cattanach, A. M.,, Taylor, M. C., Wyllie, S. (Susan), Hertz-Fowler, C., Creek, D.J. (Darren J.), Silva-Franco, F, Nes, DW, LS Biochemie van parasieten, Smith, TK, Kerkhoven, E. J., Crouch, K, Wyllie, S., Merlet, B.,, Vincent, Isabel M., Olsen, C., Tielens, A.G.M. (Lodewijk), Regenerative Medicine, Stem Cells & Cancer, Merlet, Benjamin, Taylor, M. C.,, Cottret, L., Creek, DJ, Opperdoes, FR, Ferguson, Michael AJ, Berriman, M, Opperdoes, Fred R., Logan-Klumpler, FJ, Achcar, Fiona, Barrett, M. P., Breitling, R, Urbaniak, Michael D., Denise, H. (Hubert), Fairlamb, Alan H, Merlet, B, Boshart, Michael, Fairlamb, A. H.,, Wilkinson, SR, Taylor, MC, Urbaniak, Michael D, Crouch, K.,, Breitling, R.,, Vincent, I.M. (Isabel M.), Tielens, Aloysius G M, Breitling, R. (Rainer), Boshart, M. (Michael), de Koning, Harry P, Smith, T. K.,, Michels, PA, de Koning, H. P.,, Nes, David W., Ginger, ML, Butikofer, P.,, Barrett, M. P.,, Hertz-Fowler, Christiane, Bannerman-Chukualim, B., Hertz-Fowler, C.,, Fairlamb, Alan H., Ebikeme, C, Michels, Paul A. M., Tielens, A. G. M., Taylor, Martin C, Nolan, Derek P, Maeser, P, Boshart, M.,, Taylor, Martin C., Hertz-Fowler, C, Nayak, A. (Archana), Shameer, Sanu, Ferguson, M. A. J.,, Tielens, Aloysius G.M., Cattanach, Amy M., Crouch, K., Fairlamb, Alan H.; id_orcid, Urbaniak, MD, Tielens, Lodewijk, Jourdan, F, Ferguson, Michael A. J.; id_orcid, Berriman, M., Bringaud, Frédéric, Bannerman-Chukualim, B. (Bridget), Wyllie, S.,, Silva-Franco, F. (Fatima), Wilkinson, S. R., Silva-Franco, F., Shameer, S, Bringaud, F. (Frédéric), Bannerman-Chukualim, Bridget, Michels, Paul A.M., Ginger, M. L.,, Nes, David W, Shameer, S.,, van Hellemond, Jaap J., Ferguson, M. A. J., van Hellemond, J. J., Urbaniak, M.D. (Michael D.), Nolan, D.P. (Derek P.), Wilkinson, S. R.,, Creek, Darren J., Merlet, B., Mäser, Pascal, Michels, Paul AM, Cattanach, A.M. (Amy M.), Tielens, AG, Barrett, Michael P., Jourdan, Fabien, Wyllie, Susan, Fairlamb, AH, Bringaud, F.,, Kerkhoven, Eduard J, Maeser, Pascal, Vinson, F., Bringaud, F., Creek, D. J., Berriman, M. (Matthew), Tielens, AGM, Logan-Klumpler, Flora J, Shameer, S. (Sanu), Achcar, F.,, Michels, P. A. M., Koning, Harry P. de, Logan-Klumpler, F. J., Fairlamb, A. H., Vincent, IM, Nayak, A., Logan-Klumpler, Flora J., Bütikofer, Peter, Shameer, S., Olsen, C. (Christian), Cottret, Ludovic, Ebikeme, Charles, Cottret, L.,, Nolan, DP, Michels, PAM, Tielens, A. G. M.,, Opperdoes, F. R.,, Silva-Franco, Fatima, Kerkhoven, E.J. (Eduard), Berriman, M.,, Maser, P.,, van Hellemond, Jaap J, Urbaniak, M. D., Ginger, M.L. (Michael L.), Michels, P.A.M. (Paul), Kerkhoven, EJ, Creek, D. J.,, Maser, P., Mäser, P. (Pascal), Kerkhoven, Eduard J., Merlet, B. (Benjamin), Fairlamb, A.H. (Alan H.), Achcar, F. (Fiona), Smith, T.K. (Terry K.), de Koning, H. P., Urbaniak, M. D.,, Nes, D. (DavidW.), Crouch, K. (Kathryn), Denise, H, Bannerman-Chukualim, B.,, Jourdan, F. (Fabien), Ginger, M. L., Berriman, Matthew, Tielens, Aloysius GM, Jourdan, F.,, Achcar, F, Ebikeme, C.,, Olsen, Christian, Wilkinson, Shane R, Cottret, L. (Ludovic), Hertz-Fowler, C. (Christiane), Hellemond, Jaap J. van, Kerkhoven, Eduard,, Ginger, Michael L., Ferguson, M.A.J. (Michael A. J.), Cottret, L, Vincent, I. M., Nes, D. W., Barrett, MP, de Koning, Harry P., Michels, P. A. M.,, Cattanach, Amy M, Cattanach, AM, Hellemond, J.J. (Jaap) van, Michels, Paul A M, Nolan, D. P., Wilkinson, S.R. (Shane R.), Vinson, F.,, Wilkinson, Shane R., Breitling, Rainer, Creek, Darren J, Barrett, M.P. (Michael P.), B&C BRC-SIB-TR, Tielens, Lodewijk; id_orcid, Vinson, Florence, Tielens, Aloysius G. M., Bringaud, F, Vincent, Isabel M, Logan-Klumpler, F.J. (Flora J.), Opperdoes, Fred R, Denise, H.,, Vincent, I. M.,, Olsen, C.,, van, Hellemond JJ, Ginger, Michael L, Kerkhoven, Eduard, Denise, Hubert, Smith, T. K., Taylor, M.C. (Martin C.), Vinson, F, Nayak, Archana, Ferguson, Michael A J, van Hellemond, Jaap, Smith, Terry K, Bannerman-Chukualim, B, Cattanach, A. M.   +249 more
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Adenosine-mono-phosphate-activated protein kinase-independent effects of metformin in T cells [PDF]

, 2014
The anti-diabetic drug metformin regulates T-cell responses to immune activation and is proposed to function by regulating the energy-stress-sensing adenosine-monophosphate-activated protein kinase (AMPK).
Benoit Viollet, David K. Finlay, Doreen A. Cantrell, Finlay David K., Viollet, Benoit, Marc Foretz, Cantrell, Doreen A., Viollet Benoit, FINLAY, DAVID, Marouan Zarrouk, Zarrouk, Marouan, David K Finlay, Doreen A Cantrell, Zarrouk Marouan, Foretz, Marc, Foretz Marc, Cantrell Doreen A., Finlay, David K.   +17 more
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Effect of Different Dietary Regimes on the Gut Microbiota and Fecal Metabolites of Père David’s Deer

Animals, 2022
A deep understanding of the effect of seasonal dietary changes on the nutrition and health of Père David’s deer in Dafeng Reserve will contribute greatly to Père David’s deer’s protection.
Junai Zhen, Yijun Ren, Huidan Zhang, Xueli Yuan, Libo Wang, Hua Shen, Ping Liu, Yuqing Chen   +7 more
doaj   +1 more source

System-level metabolic effects of trematode infections in rodent models [PDF]

, 2010
Background: Trematode infections impose a great burden on the developing world by impairing life quality, productivity and life span of an individual.
Saric, Jasmina
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Corynebacterium diphtheriae Proteome Adaptation to Cell Culture Medium and Serum

Proteomes, 2021
Host-pathogen interactions are often studied in vitro using primary or immortal cell lines. This set-up avoids ethical problems of animal testing and has the additional advantage of lower costs.
Jens Möller, Fatemeh Nosratabadi, Luca Musella, Jörg Hofmann, Andreas Burkovski   +4 more
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p53 regulates Mevalonate Metabolic pathway

, 2014
2012-2013The mevalonate pathway is an important metabolic pathway implicated in multiple aspects of tumorigenesis. In this study, I provided evidences about genetic and pharmacologic perturbation of p53, which directly influenced expression of mevalonate
D'Alessandro, Alba
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