Identification of Metabolic Pathway Systems
Frontiers in Genetics, 2016 The estimation of parameters in even moderately large biological systems is a significant challenge. This challenge is greatly exacerbated if the mathematical formats of appropriate process descriptions are unknown.
Sepideh eDolatshahi, Eberhard Otto Voit
doaj +1 more source
Lignin engineering in field-grown poplar trees affects the endosphere bacterial microbiome [PDF]
, 2016 Cinnamoyl-CoA reductase (CCR), an enzyme central to the lignin bio-synthetic pathway, represents a promising biotechnological target to reduce lignin levels and to improve the commercial viability of lignocellulosic biomass. However, silencing of the CCR
Beckers, Bram +6 more
core +2 more sources
Pathos: a web facility that uses metabolic maps to display experimental changes in metabolites identified by mass spectrometry [PDF]
, 2011 This work describes a freely available web-based facility which can be used to analyse raw or processed mass spectrometric data from metabolomics experiments and display the metabolites identified – and changes in their experimental abundance – in the ...
Barrett, M.P. +3 more
core +2 more sources
Serum microRNA array analysis identifies miR-140-3p, miR-33b-3p and miR-671-3p as potential osteoarthritis biomarkers involved in metabolic processes. [PDF]
, 2017 Background: MicroRNAs (miRNAs) in circulation have emerged as promising biomarkers. In this study, we aimed to identify a circulating miRNA signature for osteoarthritis (OA) patients and in combination with bioinformatics analysis to evaluate the utility
A Brazma +59 more
core +2 more sources
Impact of limited solvent capacity on metabolic rate, enzyme activities, and metabolite concentrations of S. cerevisiae glycolysis [PDF]
, 2008 The cell's cytoplasm is crowded by its various molecular components, resulting in a limited solvent capacity for the allocation of new proteins, thus constraining various cellular processes such as metabolism.
Barabási, AL +3 more
core +1 more source
Genomic reconstruction of short-chain fatty acid production by the human gut microbiota
Frontiers in Molecular Biosciences, 2022 Short-chain fatty acids (SCFAs) including acetate, formate, propionate, and butyrate are the end products of dietary fiber and host glycan fermentation by the human gut microbiota (HGM).
Maria S. Frolova +4 more
doaj +1 more source
Incomplete Wood-Ljungdahl pathway facilitates one-carbon metabolism in organohalide-respiring Dehalococcoides mccartyi. [PDF]
, 2014 The acetyl-CoA "Wood-Ljungdahl" pathway couples the folate-mediated one-carbon (C1) metabolism to either CO2 reduction or acetate oxidation via acetyl-CoA.
Alvarez-Cohen, Lisa +8 more
core +1 more source
Comprehensive Analysis of NAFLD and the Therapeutic Target Identified
Frontiers in Cell and Developmental Biology, 2021 Objective: Non-alcoholic fatty liver disease (NAFLD) is a serious health threat worldwide. The aim of this study was to comprehensively describe the metabolic and immunologic characteristics of NAFLD, and to explore potential therapeutic drug targets for
Weiheng Wen +5 more
doaj +1 more source
Application of regulatory sequence analysis and metabolic network analysis to the interpretation of gene expression data [PDF]
, 2000 We present two complementary approaches for the interpretation of clusters of co-regulated genes, such as those obtained from DNA chips and related methods.
A. Brazma +23 more
core +4 more sources
MetExploreViz: web component for interactive metabolic network visualization [PDF]
, 2017 Summary: MetExploreViz is an open source web component that can be easily embedded in any web site. It provides features dedicated to the visualization of metabolic networks and pathways and thus offers a flexible solution to analyse omics data in a ...
Chazalviel, Maxime +7 more
core +4 more sources