Results 151 to 160 of about 3,241,184 (308)

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

On the metabolic pathway of methylmethacrylate [PDF]

FEBS Letters, 1969
openaire   +2 more sources

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

METABOLIC PATHWAYS [PDF]

Neuro-Oncology, 2011
J. W. Locasale, T. Melman, S. S. Song, X. Yang, K. D. Swanson, L. C. Cantley, J. M. Asara, E. T. Wong, S. Adams, N. Braidy, C. Teo, G. Guillemin, M. Philippe, C. Carole, T. David, G. Eric, N.-M. Isabelle, M. de Paula Andre, B. Marylin, C. Olivier, O. L'Houcine, F.-B. Dominique, P. Leukel, C. Seliger, A. Vollmann, B. Jachnik, U. Bogdahn, P. Hau, X. Liu, V. S. Kumar, C. M. McPherson, L. Chow, A. Kendler, B. Dasgupta, S. Piya, E. White, S. Klein, H. Jiang, F. Lang, W. K. Alfred Yung, C. Gomez-Manzano, J. Fueyo, A. Vartanian, A. Guha, K. E. Fenton, M. Abdelwahab, A. C. Scheck, D. Guo, F. Reinitz, M. Youssef, C. Hong, D. Nathanson, D. Akhavan, D. Kuga, A. N. Amzajerdi, H. Soto, S. Zhu, I. Babic, A. Iwanami, K. Tanaka, B. Gini, J. DeJesus, D. D. Lisiero, T. Huang, R. Prins, P. Wen, H. I. Robbins, M. Prados, L. DeAngelis, I. Mellinghoff, M. Mehta, C. D. James, A. Chakravarti, T. Cloughesy, P. Tontonoz, P. Mischel, J. Phillips, J. Mukherjee, C. Cowdrey, J. Wiencke, R. O. Pieper, R. Bachoo, I. Marin-Valencia, S. Cho, D. Rakheja, K. Hatanpaa, T. Mashimo, V. Vemireddy, P. Kapur, L. Good, X. Sun, J. Pascual, M. Takahashi, O. Togao, J. Raisanen, E. A. Maher, R. DeBerardinis, C. Malloy, E. A. Maher, R. Bachoo, I. Marin-Valencia, K. Hatanpaa, C. Choi, T. Mashimo, J. Raisanen, D. Mathews, J. Pascual, C. Madden, B. Mickey, C. Malloy, R. DeBerardinis, J. Mukherjee, S. Zheng, J. Phillips, C. Cowdrey, S. Ronen, J. Wiencke, R. O. Pieper, I. Park, L. E. Jalbert, M. Ito, T. Ozawa, C. D. James, J. J. Phillips, D. B. Vigneron, R. O. Pieper, S. M. Ronen, S. J. Nelson   +127 more
openaire   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Ceramide Metabolic Pathways and Their Regulation in Adolescent Acne Vulgaris. [PDF]

Int J Mol Sci
Gou Y, Wu H, Wu X, Dong G, Li H, Yuan H, Li L.   +6 more
europepmc   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

Effects of Metabolic Pathways and Products on Early Mammalian Embryonic Development. [PDF]

Cells
Tao H, Hua Z, Wei J, Zhu X, Xiong Q.
europepmc   +1 more source