Results 231 to 240 of about 3,241,184 (308)

Longitudinal shifts in oral microbiome composition and metabolic pathways associated with preterm birth. [PDF]

mSystems
Sarkar M, Maddheshiya A, Tailor P, Nath S, Makkar N, GARBH-Ini Study Group, Misra S, Desiraju BK, Wadhwa N, Bhatnagar S, Kshetrapal P, Mukherjee S.   +11 more
europepmc   +1 more source

Region Specific miRNA–mRNA Networks in Gray and White Matter Lesions of Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Multiple sclerosis (MS) is a neurodegenerative demyelinating disease of the central nervous system. This study aimed to identify micro‐RNA (miRNA)–mRNA regulatory networks underlying region‐specific molecular mechanisms in white matter and gray matter lesions in progressive MS.
Adya Sapra, Nagendra K. Rai, Timothy D. Niepokny, Haley Courtney, Ajai Tripathi, Ranjan Dutta   +5 more
wiley   +1 more source

Impact of PFAS exposure on lipid metabolic pathways: mechanisms and implicatins in carcinogenesis. [PDF]

Front Toxicol
Ferguson EJ, Tessmann JW, Zaytseva YY.
europepmc   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Intrabody B1 targeting TDP-43 modulates neuroinflammatory and metabolic pathways in a preclinical ALS model. [PDF]

Neurotherapeutics
Al Ojaimi Y, Dupuis A, Palla M, Lanznaster D, Hergesheimer R, Galineau L, Serriere S, Chami AA, Martineau P, Alouane T, Marouillat S, Dupuy C, Schneider BL, Veyrat-Durebex C, Masse F, Trovero F, Andres CR, Corcia P, Vourcʼh P, Blasco H.   +19 more
europepmc   +1 more source

Arterial Spin‐Labeling MRI at the Cortical‐CSF Interface: A Novel Biomarker in Alzheimer Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background/Objective Arterial spin‐labeling (ASL) MRI can measure perfusion signal adjacent to CSF spaces and may provide information regarding CSF‐adjacent water transport physiology. We developed an automated pipeline to extract cortical‐CSF interface (IF) perfusion for comparison between Alzheimer disease (AD) and cognitively normal ...
Mona Asghariahmadabad, Pouya Metanat, Michael Thomas, Luke W. Bonham, Tyson Lam, Mehmet Kurt, Hong Nguyen, Tara Ellingson, Mauro Zucchelli, Stefano Casagranda, Quin Lu, Andreas M. Rauschecker, Leo Sugrue, Luis E. Savastano, Christopher P. Hess, Kamalini Ranasinghe, S. Andrew Josephson, Bruce L. Miller, Jennifer S. Yokoyama, Gil D. Rabinovici, Peter A. Ljubenkov, Lawren VandeVrede, Kambiz Nael   +22 more
wiley   +1 more source

Editorial: Metabolic reprogramming in cancer

Frontiers in Pharmacology
Valentina Audrito, Elisa Giovannetti, Elisa Giovannetti   +2 more
doaj   +1 more source

Rumen Microbiota, Predicted Metabolic Pathways, and Fermentation Parameters Exhibit Production-System-Specific Associations in Cattle and Goats. [PDF]

Microorganisms
Cui C, Zheng Y, Guo Z, Wang Z, Zhu X, Cui Y, Li D, Chen W, Shi Y, Liu B.   +9 more
europepmc   +1 more source

Safety and Efficacy of GLP‐1 Receptor Agonists in Adults With Epilepsy, Obesity, and Type 2 Diabetes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Managing obesity in patients with epilepsy is complicated by the weight‐gaining properties of essential antiseizure medications (ASMs) such as valproate and pregabalin. We evaluated the safety and efficacy of initiating glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) in this population.
Hyoshin Son, Inyoung Hwang, Sang Won Lee, Yun Kim   +3 more
wiley   +1 more source

Phenolic-Rich Lentil Extracts Regulate Cytokine Production, Metabolic Pathways and Barrier Function in Intestinal Epithelial Cells. [PDF]

Mol Nutr Food Res
Geraldo R, Machado M, Costa E, Pinho S, Gouveia A, Neves D, Freitas V, Pinto E, Pintado M, Vasconcelos MW.   +9 more
europepmc   +1 more source