Results 41 to 50 of about 3,909,262 (243)

Sensory Circumventricular Organs, Neuroendocrine Control, and Metabolic Regulation

, 2021
The central nervous system is critical in metabolic regulation, and accumulating evidence points to a distributed network of brain regions involved in energy homeostasis.
Samantha A. Dow, Colin N. Young, Jin Kwon Jeong   +2 more
core   +1 more source

Effect of DFPP on Ferroptosis in Peripheral Blood CD14+ Monocytes of Hyperlipidemic Patients Involving the ACSL4/LPCAT3/ALOX5 Pathway

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Hyperlipidemia is a major risk factor for atherosclerotic cardiovascular disease (ASCVD). Although statins are the cornerstone of lipid‐lowering therapy, their use may be limited in some patients by adverse effects. This study evaluated the possible impact of non‐drug treatment using double‐filtration plasmapheresis (DFPP) on CD14+
Yun Cheng, Lan Li, Qingmei Yang, Meipeng Wu   +3 more
wiley   +1 more source

Reciprocal regulation of protein synthesis and carbon metabolism for thylakoid membrane biogenesis [PDF]

, 2013
Metabolic control of gene expression coordinates the levels of specific gene products to meet cellular demand for their activities. This control can be exerted by metabolites acting as regulatory signals and/or a class of metabolic enzymes with dual ...
Bohne, Alexandra-Viola, Marco Schottkowski, Michael Lidschreiber, Zerges, William, Markus Piotrowski (169373), Markus Piotrowski, Michael Lidschreiber (138963), Christian Schwarz, Alexandra-Viola Bohne (281295), Marco Schottkowski (281297), William Zerges, Nickelsen, Jörg, Jörg Nickelsen (13576), Piotrowski, Markus, Alexandra-Viola Bohne, Christian Schwarz (281296), Lidschreiber, Michael, Jörg Nickelsen, Schottkowski, Marco, Schwarz, Christian, William Zerges (95563)   +20 more
core   +1 more source

FSP1 confers ferroptosis resistance in KEAP1 mutant non-small cell lung carcinoma in NRF2-dependent and -independent manner

Cell Death and Disease, 2023
Ferroptosis, a type of cell death induced by lipid peroxidation, has emerged as a novel anti-cancer strategy. Cancer cells frequently acquire resistance to ferroptosis. However, the underlying mechanisms are poorly understood.
Jong Woo Kim, Min-Ju Kim, Tae-Hee Han, Ji-Yoon Lee, Sangok Kim, Hyerin Kim, Kyoung-Jin Oh, Won Kon Kim, Baek-Soo Han, Kwang-Hee Bae, Hyun Seung Ban, Soo Han Bae, Sang Chul Lee, Haeseung Lee, Eun-Woo Lee   +14 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

The logics of metabolic regulation in bacteria challenges biosensor-based metabolic engineering

, 2017
Synthetic Biology (SB) aims at the rational design and engineering of novel biological functions and systems. By facilitating the engineering of living organisms, SB promises to facilitate the development of many new applications for health ...
Matthieu Jules, Jules, Matthieu
core   +1 more source

A Bivariate Genome-Wide Approach to Metabolic Syndrome STAMPEED Consortium [PDF]

, 2010
OBJECTIVE The metabolic syndrome (MetS) is defined as concomitant disorders of lipid and glucose metabolism, central obesity, and high blood pressure, with an increased risk of type 2 diabetes and cardiovascular disease.
O'Reilly, Paul F., David J. Couper, Marjo-Riitta Jarvelin, Mathias, Rasika A., Sun, Y. V., Becker, DM, Zhang, Q., Psaty, Bruce M., Dhananjay Vaidya, Assimes, Themistocles L., Rotter, Jerome I, Cashell Jaquish, Becker, LC, McCarthy, Mark I, Boerwinkle, E., Franceschini, Nora, O'Reilly, P. F., O'Reilly, Paul F, Feitosa, MF, Hartikainen, A.-L., Yanek, L., Knowles, JW, Bruce M. Psaty, Becker, Diane M, Mathias, RA, Lewis C. Becker, Goodarzi, Mark O., Kardia, Sharon LR, Glazer, NL, Themistocles L. Assimes, Kraja, Aldi T, Couper, D. J., Mathias, Rasika A, Couper, DJ, Kardia, SL, Kullo, I. J., Rasika A. Mathias, Province, Michael A., Guo Li, Borecki, IB, Absher, Devin, Borecki, Ingrid B., Chakravarti, A, Iribarren, C., Yanek, Lisa, Kari E. North, Jaquish, Cashell, O’Reilly, Paul F, Sovio, U., Becker, D. M., Sun, Yan V, Kraja, AT, Paul F. O’Reilly, Yii-Der Ida Chen, Lisa Yanek, Vaidya, D., Quertermous, Thomas, Chen, Yii-Der Ida, Leena Palotie, Sun, Yan V., Boerwinkle, Eric, Aldi T. Kraja, Goodarzi, Mark O, Pankow, JS, Talin Haritunians, Psaty, Bruce M, Palotie, L., Boerwinkle, E, Zhang, Q, Becker, L. C., Kral, Brian, Sovio, U, Feitosa, Mary F., Haritunians, T., North, Kari E., Haritunians, Talin, Brian Kral, Quertermous, T., Chen, Y.-d. I., Hartikainen, Anna-Liisa, Feitosa, Mary F, Chakravarti, A., Jarvelin, Marjo-Riitta, Hartikainen, AL, Mark O. Goodarzi, Diane M. Becker, Chakravarti, Aravinda, Sharon L.R. Kardia, Mary F. Feitosa, Palotie, L, Couper, David J., Anna-Liisa Hartikainen, Borecki, I. B., Nora Franceschini, Jarvelin, MR, North, Kari E, Knowles, Joshua W, Pankow, James S, Jerome I. Rotter, Couper, David J, Franceschini, N., McCarthy, M. I., Iribarren, C, Psaty, BM, Yanek, L, Vaidya, Dhananjay, Psaty, B. M., Kral, B, Becker, Lewis C, Kral, B., Michael A. Province, Ingrid B. Borecki, Chen, YD, Goodarzi, M. O., Glazer, N. L., Becker, Lewis C., Palotie, Leena, Jaquish, C., Kraja, Aldi T., Glazer, Nicole L, Kullo, IJ, Thomas Quertermous, Kullo, Iftikhar J, Joshua W. Knowles, Carlos Iribarren, Zhang, Qunyuan, Quertermous, T, Ulla Sovio, Li, Guo, Haritunians, T, Mathias, R. A., Jarvelin, M.-r., Sovio, Ulla, Qunyuan Zhang, Iftikhar J. Kullo, Province, Michael A, Rotter, J. I., Pankow, James S., Province, MA, McCarthy, MI, James S. Pankow, Knowles, J. W., Borecki, Ingrid B, Li, G, Eric Boerwinkle, Becker, Diane M., Kardia, Sharon L. R., Glazer, Nicole L., O'Reilly, PF, Sun, YV, North, K. E., Li, G., Mark I. McCarthy, Absher, D, Iribarren, Carlos, Vaidya, D, Absher, D., Feitosa, M. F., Franceschini, N, Aravinda Chakravarti, Knowles, Joshua W., Assimes, Themistocles L, Yan V. Sun, Kardia, S. L. R., Pankow, J. S., Rotter, Jerome I., Assimes, TL, Devin Absher, McCarthy, Mark I., North, KE, Assimes, T. L., Goodarzi, MO, Province, M. A., Jaquish, C, Nicole L. Glazer, Rotter, JI, Kraja, A. T., Kullo, Iftikhar J.   +177 more
core   +1 more source

Imeglimin enhances glucagon secretion through an indirect mechanism and improves fatty liver in high‐fat, high‐sucrose diet‐fed mice

Journal of Diabetes Investigation
Aims/Introduction Imeglimin is a recently approved oral antidiabetic agent that improves insulin resistance, and promotes insulin secretion from pancreatic β‐cells.
Osamu Kikuchi, Yuichi Ikeuchi, Masaki Kobayashi, Yoko Tabei, Hiromi Yokota‐Hashimoto, Tadahiro Kitamura   +5 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source