Results 21 to 30 of about 3,909,262 (243)

The regulation of metabolic gene expression in human skeletal muscle by exercise: the influence of exercise intensity and contraction frequency [PDF]

, 2010
Skeletal muscle contraction increases energy expenditure and improves metabolic flexibility, but is also a key regulator of metabolic gene expression.
Carson, Brian
core   +2 more sources

Neuronal SIRT1 regulates macronutrient-based diet selection through FGF21 and oxytocin signalling in mice

Nature Communications, 2018
SIRT1 is a NAD+-dependent deacetylase whose functions have been linked to organismal longevity, aging and metabolism. Here, Matsui and colleagues show that neuronal SIRT1 can affect nutrient-related dietary choice in mice, and this effect is mediated by ...
Sho Matsui, Tsutomu Sasaki, Daisuke Kohno, Keisuke Yaku, Ayumu Inutsuka, Hiromi Yokota-Hashimoto, Osamu Kikuchi, Takayoshi Suga, Masaki Kobayashi, Akihiro Yamanaka, Akihiro Harada, Takashi Nakagawa, Tatsushi Onaka, Tadahiro Kitamura   +13 more
doaj   +1 more source

Interactions in the (Pre)metastatic Niche Support Metastasis Formation

Frontiers in Oncology, 2019
Metastasis formation is the leading cause of death in cancer patients. Thus, understanding and targeting this process is an unmet need. Crucial steps during the establishment of metastases include the (pre)metastatic niche formation.
Ginevra Doglioni, Ginevra Doglioni, Sweta Parik, Sweta Parik, Sarah-Maria Fendt, Sarah-Maria Fendt   +5 more
doaj   +1 more source

Prognostic significance of liver stiffness assessed by fibrosis‐4 index in patients with heart failure

ESC Heart Failure, 2021
Background Heart failure (HF)‐related congestive hepatopathy is a well‐recognized problem in management of HF. The fibrosis‐4 (FIB4) index calculated by [age × aspartate aminotransferase (IU/L)/platelet count (109/L) × square root of alanine ...
Masafumi Takae, Koichiro Fujisue, Eiichiro Yamamoto, Koichi Egashira, Takashi Komorita, Fumi Oike, Taiki Nishihara, Masahiro Yamamoto, Kyoko Hirakawa, Noriaki Tabata, Takanori Tokitsu, Kenshi Yamanaga, Daisuke Sueta, Shinsuke Hanatani, Taishi Nakamura, Hiroki Usuku, Satoshi Araki, Yuichiro Arima, Seiji Takashio, Satoru Suzuki, Koichi Kaikita, Kenichi Matsushita, Kenichi Tsujita   +22 more
doaj   +1 more source

Evolution under Fluctuating Environments Explains Observed Robustness in Metabolic Networks [PDF]

, 2010
Copyright: © 2010 Soyer, Pfeiffer. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and ...
Pfeiffer, Thomas, Thomas Pfeiffer, Orkun S. Soyer, Soyer Orkun S., Orkun S Soyer, Soyer, Orkun S., Pfeiffer Thomas   +6 more
core   +1 more source

Double‐chambered right ventricle complicated by hypertrophic obstructive cardiomyopathy diagnosed as Noonan syndrome

ESC Heart Failure, 2020
We present a case of double‐chambered right ventricle (DCRV) complicated by hypertrophic obstructive cardiomyopathy (HOCM) in KRAS mutation‐associated Noonan syndrome.
Masahiro Yamamoto, Seiji Takashio, Naoya Nakashima, Shinsuke Hanatani, Yuichiro Arima, Kenji Sakamoto, Eiichiro Yamamoto, Koichi Kaikita, Yoko Aoki, Kenichi Tsujita   +9 more
doaj   +1 more source

Identification of a key ceRNA network associated with ferroptosis in gastric cancer

Scientific Reports, 2022
Ferroptosis, a newly discovered irondependent form of regulated cell death caused by excessive accumulation of lipid peroxides, is linked to the development and treatment response of various types of cancer, including gastric cancer (GC). Noncoding RNAs (
Wen Jin, Jianli Liu, Jie Yang, Zongqi Feng, Zhenxing Feng, Na Huang, Tingyu Yang, Lan Yu   +7 more
doaj   +1 more source

Chronic cold exposure induces autophagy to promote fatty acid oxidation, mitochondrial turnover, and thermogenesis in brown adipose tissue

iScience, 2021
Summary: Autophagy plays an important role in lipid breakdown, mitochondrial turnover, and mitochondrial function during brown adipose tissue (BAT) activation by thyroid hormone, but its role in BAT during adaptive thermogenesis remains controversial ...
Winifred W. Yau, Kiraely Adam Wong, Jin Zhou, Nivetha Kanakaram Thimmukonda, Yajun Wu, Boon-Huat Bay, Brijesh Kumar Singh, Paul Michael Yen   +7 more
doaj   +1 more source

Metabolic Networks of Longevity [PDF]

, 2010
Molecular and cellular networks implicated in aging depend on a multitude of proteins that collectively mount adaptive and contingent metabolic responses to environmental challenges.
Williams, Robert W., Robert W. Williams, Houtkooper, Riekelt H., Riekelt H. Houtkooper, Johan Auwerx, Auwerx, Johan   +5 more
core   +1 more source

Impact of Reactive Oxidative Metabolites Among New Categories of Nonischemic Heart Failure

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background We investigated the clinical significance of derivatives of reactive oxygen metabolites (DROMs), a new marker of reactive oxygen species, in patients with nonischemic heart failure (HF) and compared them among new categories of HF. Methods and
Taiki Nishihara, Eiichiro Yamamoto, Daisuke Sueta, Koichiro Fujisue, Hiroki Usuku, Fumi Oike, Masafumi Takae, Noriaki Tabata, Miwa Ito, Kenshi Yamanaga, Hisanori Kanazawa, Yuichiro Arima, Satoshi Araki, Seiji Takashio, Taishi Nakamura, Satoru Suzuki, Kenji Sakamoto, Yasuhiro Izumiya, Koichi Kaikita, Kenichi Tsujita   +19 more
doaj   +1 more source