Results 1 to 10 of about 958,564 (99)
GADD45β Regulates Hepatic Gluconeogenesis via Modulating the Protein Stability of FoxO1
Biomedicines, 2021 Increased hepatic gluconeogenesis is one of the main contributors to the development of type 2 diabetes. Recently, it has been reported that growth arrest and DNA damage-inducible 45 beta (GADD45β) is induced under both fasting and high-fat diet (HFD ...
Hyunmi Kim +10 more
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Lipid Metabolism and Ferroptosis
Biology, 2021 Ferroptosis is a type of iron-dependent regulated necrosis induced by lipid peroxidation that occurs in cellular membranes. Among the various lipids, polyunsaturated fatty acids (PUFAs) associated with several phospholipids, such as ...
Ji-Yoon Lee +4 more
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An integrated view of lipid metabolism in ferroptosis revisited via lipidomic analysis
Experimental and Molecular Medicine, 2023 Ferroptosis is a form of regulated cell death characterized by iron-dependent lipid peroxidation. This process contributes to cellular and tissue damage in various human diseases, such as cardiovascular diseases, neurodegeneration, liver disease, and ...
Jong Woo Kim +3 more
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International Journal of Endocrinology, 2023 Introduction. Insulin-like growth factor receptor 2 (IGF2R) regulates placental nutrient transport, and its soluble form is related to obesity in adults. If the placental expression of IGF2R is altered in women with obesity is unknown.
Juan José Castro +4 more
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NAD+ augmentation ameliorates acute pancreatitis through regulation of inflammasome signalling
Scientific Reports, 2017 Acute pancreatitis (AP) is a complicated disease without specific drug therapy. The cofactor nicotinamide adenine dinucleotide (NAD+) is an important regulator of cellular metabolism and homeostasis. However, it remains unclear whether modulation of NAD+
AiHua Shen +15 more
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Frontiers in Oncology, 2022 Gene therapy is one of the target therapies with promising clinical use for gastric cancer (GC). However, the delivery of the CRISPR/Cas9/sgRNA (RNP) gene editing tool severely limits the practical therapeutic effect of GC.
Zhouying Wu +12 more
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International Journal of Cardiology: Heart & Vasculature, 2020 Backgrounds: The relationship between cardiovascular outcomes and the Controlling Nutritional Status (CONUT) score in heart failure (HF) with preserved ejection fraction (HFpEF) patients is unknown.
Takashi Komorita +17 more
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CDK13-Mediated Cell Cycle Disorder Promotes Tumorigenesis of High HMGA2 Expression Gastric Cancer
Frontiers in Molecular Biosciences, 2021 The inhibitor of CDK4/6 has been clinically used for treating certain types of cancer which are characterized by G0/G1 acceleration induced by the CDK4/6-RB1 pathway.
Zhouying Wu +12 more
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Microbial Cell Factories, 2018 Background Proprotein convertase furin is responsible for the processing of a wide variety of precursors consisted of signal peptide, propeptide and mature peptide in mammal.
Yide Huang +6 more
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Alpha-centractin is a novel substrate of SETD3 methyltransferase in vitro [PDF]
PeerJBackground The SETD3 enzyme, a protein histidine methyltransferase, catalyzes the Nτ-methylation of the histidine 73 residue in β-actin. This post-translational modification is important for maintaining cytoskeleton integrity, and actin remains the only ...
Apolonia Witecka +6 more
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