Results 11 to 20 of about 3,909,262 (243)

Metabolic regulation of regulatory T cell development and function [PDF]

, 2014
It is now well established that the effector T cell (Teff) response is regulated by a series of metabolic switches. Quiescent T cells predominantly require ATP-generating processes, whereas proliferating Teff require high metabolic flux through growth ...
Marelli-Berg, F, Madhav eKishore, Kishore, M, Federica eMarelli-Berg, Federica Marelli-Berg, Coe, DJ, David John Coe, Madhav Kishore   +7 more
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New insights in the regulation of skeletal muscle PGC-1α by exercise and metabolic diseases [PDF]

, 2013
Skeletal muscle energy metabolism is severely impaired in insulin resistant and type 2 diabetic patients. In particular, deregulated transcription of oxidative metabolism genes has been linked to the development of non-communicable metabolic diseases ...
Handschin, Christoph, Pérez-Schindler, Joaquín   +1 more
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Integrative analyses of genetic variation in enzyme activities of primary carbohydrate metabolism reveal distinct modes of regulation in Arabidopsis thaliana [PDF]

, 2008
Background Plant primary carbohydrate metabolism is complex and flexible, and is regulated at many levels. Changes of transcript levels do not always lead to changes in enzyme activities, and these do not always affect metabolite levels and fluxes.
Fu, Jingyuan, Vreugdenhil, Dick, Fu, Jingyuan; id_orcid, Keurentjes, Joost Jb, Keurentjes, J. J. B., Steinhauser, Marie-Caroline, Koornneef, Maarten, Koornneef, M., Steinhauser, M. C., Steinhauser, M., Steinhauser, C., Keurentjes, Joost J. B., Keurentjes, J., Gibon, Y., Keurentjes, J.J.B., Sulpice, R., Gibon, Yves, Stitt, M., Steinhauser, M.C., Sulpice, Ronan, Vreugdenhil, D., Fu, J. Y., Fu, J., Stitt, Mark   +23 more
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Fibroblast growth factor signaling in metabolic regulation [PDF]

, 2016
The prevalence of obesity is a growing health problem. Obesity is strongly associated with several comorbidities, such as non-alcoholic fatty liver disease, certain cancers, insulin resistance and type 2 diabetes, which all reduce life expectancy and ...
Atkins, Annette R., Nies, Vera J. M., Weilin eLiu, Gencer Sancar, Struik, Dicky; id_orcid, Ruth eYu, Jonker, Johan W.; id_orcid, Annette eAtkins, Dicky Struik, Ruth T. Yu, Ronald eEvans, Tim van Zutphen, Struik, Dicky, Liu, Weilin, Yu, Ruth T., Johan W. Jonker, Evans, Ronald M., Vera J. M. Nies, Gencer eSancar, Dicky eStruik, Ronald M. Evans, Jonker, Johan W., Sancar, Gencer, Vera eNies, Weilin Liu, Johan eJonker, van Zutphen, Tim, Downes, Michael Robert, Tim evan Zutphen, Michael Robert Downes, Annette R. Atkins   +30 more
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Path finding methods accounting for stoichiometry in metabolic networks [PDF]

, 2011
Copyright © 2011 Pey et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution ...
Prada, J, Francisco J Planes, Joaquín Prada, Beasley, JE, Pey, J, John E Beasley, Pey, Jon, Prada, Joaquin, Jon Pey, Planes, Francisco J, Planes, FJ, Beasley, John E   +11 more
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Systematic assignment of thermodynamic constraints in metabolic network models [PDF]

, 2006
Background: The availability of genome sequences for many organisms enabled the reconstruction of several genome-scale metabolic network models. Currently, significant efforts are put into the automated reconstruction of such models.
Kümmel, Anne,, Anne Kümmel, Sven Panke, Matthias Heinemann, Heinemann, Matthias, Heinemann Matthias, Panke, Sven, Heinemann, Matthias,, Kümmel, Anne, Panke, Sven,, Panke Sven, Heinemann, Matthias; id_orcid, Kümmel Anne   +12 more
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Bacterial adaptation through distributed sensing of metabolic fluxes [PDF]

, 2010
The recognition of carbon sources and the regulatory adjustments to recognized changes are of particular importance for bacterial survival in fluctuating environments.
J. B. Zaugg, Heinemann, M.,, Kotte, Oliver,, M. Heinemann, O. Kotte, Heinemann, Matthias, Matthias Heinemann, Zaugg, Judith B., Zaugg, Judith B.,, Heinemann, Matthias,, Kotte, Oliver, Heinemann, Matthias; id_orcid, Judith B Zaugg, Kotte, O.,, Oliver Kotte, Zaugg, J.B.,   +15 more
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Targeting extracellular nutrient dependencies of cancer cells

Molecular Metabolism, 2020
Background: Cancer cells rewire their metabolism to meet the energetic and biosynthetic demands of their high proliferation rates and environment. Metabolic reprogramming of cancer cells may result in strong dependencies on nutrients that could be ...
Javier Garcia-Bermudez, Robert T. Williams, Rohiverth Guarecuco, Kıvanç Birsoy   +3 more
doaj   +1 more source

Clinically Relevant Dose of Pemafibrate, a Novel Selective Peroxisome Proliferator-Activated Receptor α Modulator (SPPARMα), Lowers Serum Triglyceride Levels by Targeting Hepatic PPARα in Mice

Biomedicines, 2022
Pemafibrate (PEM) is a novel lipid-lowering drug classified as a selective peroxisome proliferator-activated receptor α (PPARα) modulator whose binding efficiency to PPARα is superior to that of fibrates. This agent is also useful for non-alcoholic fatty
Zhe Zhang, Pan Diao, Xuguang Zhang, Takero Nakajima, Takefumi Kimura, Naoki Tanaka   +5 more
doaj   +1 more source

Metabolic modeling and analysis of the metabolic switch in Streptomyces coelicolor [PDF]

, 2010
Background The transition from exponential to stationary phase in Streptomyces coelicolor is accompanied by a major metabolic switch and results in a strong activation of secondary metabolism.
Maria E Merlo, Wellington Elizabeth MH, David A Hodgson, Breitling, Rainer, Breitling, R., Hodgson, David A.,, Breitling, Rainer,, Breitling, R, Breitling Rainer, Merlo, Maria E., Wellington, Elizabeth M H, Wellington, EMH, Merlo, Maria E.,, Mohammad T Alam, Eriko Takano, Hodgson, D.A., Takano, Eriko,, Hodgson, David A., Alam, M.T., Takano Eriko, Hodgson, D. A., STREAM Consortium, Alam, Mohammad T.,, Takano, E, Takano, E., Merlo, ME, Rainer Breitling, Hodgson, DA, Wellington, Elizabeth M. H., Wellington, Elizabeth M.H.,, Merlo, M.E., Wellington, E.M.H., Alam, Mohammad T., Alam, MT, Alam Mohammad T, Takano, Eriko, Merlo Maria E, Elizabeth MH Wellington, HASH(0x55a67fd0c960), Hodgson David A, Wellington, E. M. H., Takano, Eriko; id_orcid, Merlo, Maria E.; id_orcid, The STREAM Consortium (stream)   +43 more
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