Results 121 to 130 of about 5,645,921 (292)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Insulin resistance and lipid metabolism [PDF]

Revista da Associação Médica Brasileira, 2009
Ikeoka, Dimas, Krusinova, Eva
openaire   +4 more sources

Entomological longitudinal surveys in two contrasted eco-climatic settings in Cameroon reveal a high malaria transmission from Anopheles funestus associated with GSTe2 metabolic resistance. [PDF]

BMC Infect Dis, 2023
Natchema S Fonkou B, Tchouakui M, Menze BD, Mugenzi LMJ, Fofie D, Nguiffo-Nguete D, Nkengazong L, Tombi J, Wondji CS.   +8 more
europepmc   +2 more sources

Mechanisms of pyrethroid resistance inHaematobia irritans (Muscidae) from Mato Grosso do Sul state, Brazil

Revista Brasileira de Parasitologia Veterinária
Horn fly resistance to pyrethroid insecticides occurs throughout Brazil, but knowledge about the involved mechanisms is still in an incipient stage. This survey was aimed to identify the mechanisms of horn fly resistance to cypermethrin in Mato Grosso do
Antonio Thadeu Medeiros Barros, Teresinha Tizu Sato Schumaker, Wilson Werner Koller, Guilherme Marcondes Klafke, Thais Aguiar de Albuquerque, Rodrigo Gonzalez   +5 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Characteristics of Urinary Tract Infections in Patients with Diabetes from Timișoara, Romania: Prevalence, Etiology, and Antimicrobial Resistance of Uropathogens

Medicina
Background and Objectives: Diabetic patients are more likely to develop infections compared to the general population, especially urinary tract infections (UTIs). The aim of this study was to assess the prevalence of UTIs in a population of patients with
Teodora Sorescu, Monica Licker, Romulus Timar, Corina Musuroi, Delia Muntean, Adela Voinescu, Dan Dumitru Vulcanescu, Andrei Cosnita, Silvia-Ioana Musuroi, Bogdan Timar   +9 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Stratification of Pro-Atherogenic Phenotypes in Prediabetes Using Machine Learning

Biomedicines
Background/Objectives: Prediabetes is a metabolic condition involving various phenotypes of glucose metabolism. Prediabetes increases the risk of heart disease, among other conditions.
Liana Signorini, Waldemar Volanski, Ademir Luiz do Prado, Glaucio Valdameri, Mauren Isfer Anghebem, Vivian Rotuno Moure, Marcel Henrique Marcondes Sari, Geraldo Picheth, Fabiane Gomes de Moraes Rego   +8 more
doaj   +1 more source

The effect of voluntary exercise on light cycle stress-induced metabolic resistance. [PDF]

Phys Act Nutr, 2023
Moon HY, Jeong IC.
europepmc   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source