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Insulin resistance and lipid metabolism
The American Journal of Cardiology, 1999The 3 major components of the dyslipidemia of insulin resistance are increased triglyceride levels, decreased high-density lipoprotein (HDL) cholesterol, and changes in the composition of low-density lipoprotein (LDL) cholesterol. Hyperinsulinemia and the central obesity that typically accompanies insulin resistance are thought to lead to ...
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Carbohydrate Metabolism, Insulin Resistance, and Metabolic Cardiovascular Syndrome
Journal of Cardiovascular Pharmacology, 1992Insulin resistance is seen in several pathophysiological conditions, such as obesity, diabetes mellitus, and essential hypertension. This means that a greater than normal amount of insulin is needed to give a normal biological response. A major biochemical defect in insulin resistance seems to be a defect in the intracellular nonoxidative metabolism of
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Insulin Resistance, Carbohydrate Metabolism, and Hypertension
American Journal of Hypertension, 1991Hypertension and diabetes are common diseases in Westernized civilizations, and in the United States, the frequency of both diseases is increasing as the society ages. Factors contributing to the high prevalence and increasing frequency of these diseases include obesity, hyperinsulinemia and insulin resistance, genetic factors, and abnormal cellular ...
J R, Sowers +4 more
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Science, 2019
Metabolism Once imported into cells and phosphorylated, the glucose analog 2-deoxyglucose (2DG) inhibits glycolysis. As glycolysis is up-regulated in many cancers, 2DG has been proposed as a treatment. Using yeast as a model, Defenouillere et al. investigated how cells become resistant to 2DG.
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Metabolism Once imported into cells and phosphorylated, the glucose analog 2-deoxyglucose (2DG) inhibits glycolysis. As glycolysis is up-regulated in many cancers, 2DG has been proposed as a treatment. Using yeast as a model, Defenouillere et al. investigated how cells become resistant to 2DG.
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Metabolic programming in the pathogenesis of insulin resistance
Reviews in Endocrine and Metabolic Disorders, 2007This review focuses on different animal models of nutrient perturbations, inclusive of restrictive and excessive states mimicking human situations during pregnancy and lactation that cause aberrations in the offspring. These aberrations consist of diminished insulin sensitivity in the presence of defective insulin production.
Sherin U, Devaskar +1 more
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Metabolic control of antifungal drug resistance
Fungal Genetics and Biology, 2010Fungi have evolved an elegant repertoire of mechanisms to survive the cellular stress exerted by antifungal drugs such as azoles, which inhibit ergosterol biosynthesis inducing cell membrane stress. The evolution and maintenance of diverse resistance phenotypes is contingent upon cellular circuitry regulated by the molecular chaperone Hsp90 and its ...
Nicole, Robbins +3 more
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Insulin, Cation Metabolism and Insulin Resistance
Journal of Basic and Clinical Physiology and Pharmacology, 1998There is considerable evidence that insulin and insulin-like growth factors regulate a number of important physiological functions in a variety of tissues, some not considered to be classically insulin sensitive. Impaired biological responses to insulin and related insulin-like growth factors are referred to as insulin resistance.
J R, Sowers, B, Draznin
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Lipid metabolism and insulin resistance in cirrhosis
Journal of Hepatology, 1994Fasting patients with cirrhosis have high plasma non-esterified fatty acids, and a high turnover and oxidation of non-esterified fatty acids, despite high plasma insulin levels. To assess whether increased non-esterified fatty acid availability impairs utilisation of circulating glucose, and contributes to the insulin insensitivity in cirrhosis, we ...
G L, Kaye +5 more
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Hypertriglyceridemia, insulin resistance, and the metabolic syndrome
The American Journal of Cardiology, 1999The metabolic syndrome consists of a cluster of metabolic disorders, many of which promote the development of atherosclerosis and increase the risk of cardiovascular disease events. Insulin resistance may lie at the heart of the metabolic syndrome. Elevated serum triglycerides commonly associate with insulin resistance and represent a valuable clinical
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Iron metabolism and drug resistance in cancer
BioMetals, 2017Iron is an essential inorganic element for various cellular events. It is directly associated with cell proliferation and growth; therefore, it is expected that iron metabolism is altered in tumor cells which usually have rapid growth rates. The studies on iron metabolism of tumor cells have shown that tumor cells necessitated higher concentrations of ...
Kazan, Hasan Huseyin +2 more
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