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Genetics of metabolic resistance
Mathematical Biosciences, 2016Herbicide resistance has become a major issue for many weeds. Metabolic resistance refers to the biochemical processes within organisms that degrade herbicides to less toxic compounds, resulting in a shift of the dose response curve. This type of resistance involves polygenic inheritance.
Richter, Otto +2 more
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Resistance to obesity and resistance to atherosclerosis: Is there a metabolic link?
Nutrition, Metabolism and Cardiovascular Diseases, 2007This review deals with the question whether resistance to obesity affects resistance to atherosclerosis.Resistance to diet-induced obesity in inbred mouse strains involves an adequate response to Leptin, the main regulator of the energy balance cycle.
Olga, Stein, Yechezkiel, Stein
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Myocardial Resistance to Metabolic Acidosis
Archives of Surgery, 1966SOME OF the cardiovascular problems and difficulties in resuscitation occurring during shock, massive transfusions, hypothermia, and the postcardiac arrest period have been attributed to the myocardial depressant effects of the concomittant metabolic acidosis.
N Y, Smith, A N, Corbascio
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Metabolic mechanisms of antibiotic resistance
Nature Reviews Genetics, 2021In a study in Science, Lopatkin et al. identify mutations in metabolic genes of Escherichia coli that lead to antibiotic resistance. Functional analyses of the mutations support the view that metabolic dysfunction helps pathogens escape the lethal effects of antibiotics.
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Carbohydrate Metabolism in Shock Resistance
1973At the annual meeting of the Hungarian Society of Physiological Sciences (1970) we reported on the results of our earlier investigation dealing with the carbohydrate metabolism in shock. It has been shown by Karady et al., (1948, 1961) that numerous changes found in shock do not occur or are modified in the so-called “stage of resistance”. Therefore it
A, Bardoczi, J, Arokszallasi, S, Karady
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Insulin resistance and lipid metabolism
The American Journal of Cardiology, 1999The 3 major components of the dyslipidemia of insulin resistance are increased triglyceride levels, decreased high-density lipoprotein (HDL) cholesterol, and changes in the composition of low-density lipoprotein (LDL) cholesterol. Hyperinsulinemia and the central obesity that typically accompanies insulin resistance are thought to lead to ...
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Insulin resistance and glycine metabolism in humans
Amino Acids, 2017Plasma glycine level is low in patients with obesity or diabetes and the improvement of insulin resistance increases plasma glycine concentration. In prospective studies, hypoglycinemia at baseline predicts the risk of developing type 2 diabetes and higher serum glycine level is associated with decreased risk of incident type 2 diabetes.
M, Adeva-Andany +5 more
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Insulin resistance and lipoprotein metabolism
Current Opinion in Lipidology, 1995Dyslipidaemia in insulin resistance comprises elevated plasma triglycerides, decreased HDL, a preponderance of small, dense LDL and increased postprandial lipaemia. In terms of cause and effect, small, dense LDL, alimentary hyperlipidaemia and changes in HDL are consequences of elevated triglycerides.
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Iron metabolism and drug resistance in cancer
BioMetals, 2017Iron is an essential inorganic element for various cellular events. It is directly associated with cell proliferation and growth; therefore, it is expected that iron metabolism is altered in tumor cells which usually have rapid growth rates. The studies on iron metabolism of tumor cells have shown that tumor cells necessitated higher concentrations of ...
Kazan, Hasan Huseyin +2 more
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Metabolic control of antifungal drug resistance
Fungal Genetics and Biology, 2010Fungi have evolved an elegant repertoire of mechanisms to survive the cellular stress exerted by antifungal drugs such as azoles, which inhibit ergosterol biosynthesis inducing cell membrane stress. The evolution and maintenance of diverse resistance phenotypes is contingent upon cellular circuitry regulated by the molecular chaperone Hsp90 and its ...
Nicole, Robbins +3 more
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