Results 11 to 20 of about 3,890,227 (163)

¹H HR-MAS NMR Based Metabolic Profiling of Lung Cancer Cells with Induced and De-Induced Cisplatin Resistance to Reveal Metabolic Resistance Adaptations. [PDF]

Molecules, 2021
Cisplatin (cisPt) is an important drug that is used against various cancers, including advanced lung cancer. However, drug resistance is still a major ongoing problem and its investigation is of paramount interest.
Vermathen M, von Tengg-Kobligk H, Hungerbühler MN, Vermathen P, Ruprecht N.   +4 more
europepmc   +3 more sources

Metabolic checkpoint of ferroptosis resistance [PDF]

Molecular & Cellular Oncology, 2021
The metabolic checkpoint of ferroptosis remains obscure. We find that glucose favors system xc- inhibitor-induced ferroptosis by activating pyruvate oxidation, thereby promoting fatty acid synthesis and subsequent lipid peroxidation. In contrast, the upregulation of pyruvate dehydrogenase kinase 4 (PDK4) switches into a ferroptosis-resistant state in ...
Jiao Liu, Rui Kang, Daolin Tang
openaire   +3 more sources

Metabolic Resistance in Bed Bugs [PDF]

Insects, 2011
Blood-feeding insects have evolved resistance to various insecticides (organochlorines, pyrethroids, carbamates, etc.) through gene mutations and increased metabolism. Bed bugs (Cimex lectularius) are hematophagous ectoparasites that are poised to become one of the major pests in households throughout the United States. Currently, C.
Mamidala, Praveen, Jones, Susan C., Mittapalli, Omprakash   +2 more
openaire   +3 more sources

Metabolic Plasticity in Chemotherapy Resistance [PDF]

Frontiers in Oncology, 2020
Resistance of cancer cells to chemotherapy is the first cause of cancer-associated death. Thus, new strategies to deal with the evasion of drug response and to improve clinical outcomes are needed. Genetic and epigenetic mechanisms associated with uncontrolled cell growth result in metabolism reprogramming.
Maria Andrea Desbats, Maria Andrea Desbats, Isabella Giacomini, Tommaso Prayer-Galetti, Monica Montopoli, Monica Montopoli   +5 more
openaire   +3 more sources

Metabolic regulation of antibiotic resistance [PDF]

FEMS Microbiology Reviews, 2011
It is generally assumed that antibiotics and resistance determinants are the task forces of a biological warfare in which each resistance determinant counteracts the activity of a specific antibiotic. According to this view, antibiotic resistance might be considered as a specific response to an injury, not necessarily linked to bacterial metabolism ...
Martínez, José L., Rojo, Fernando
openaire   +2 more sources

Nutritional modulation of insulin resistance [PDF]

, 2012
Insulin resistance has been proposed as the strongest single predictor for the development of Type 2 Diabetes (T2DM). Chronic oversupply of energy from food, together with inadequate physical activity, have been recognized as the most relevant factors ...
Weickert, Martin O., Martin O. Weickert
core   +1 more source

Prevalence of the metabolic syndrome in Chinese adolescents [PDF]

, 2008
Since national figures on the occurrence of metabolic syndrome among Chinese adolescents are lacking, this study aims to estimate its prevalence and distribution among Chinese youngsters.
Yang, X., Kok, F.J., Zhai, F., Li, Y., Piao, J., Zhang, J., Ma, G.   +6 more
core   +1 more source

Cholesterol metabolism and resistance to tamoxifen

Current Opinion in Pharmacology, 2012
The oncoprotein MUC-1 was shown to upregulate the transcription of genes encoding cholesterol and lipid metabolic enzymes and correlated with a resistance to Tamoxifen (Tam) despite the presence of estrogen receptor α in breast cancer tumors. The importance of this observation is supported by molecular studies on Tam suggesting two additional ...
Poirot, Marc, Silvente-Poirot, Sandrine, Weichselbaum, Ralph   +2 more
openaire   +2 more sources

The role of the small intestine in the development of dietary fat-induced obesity and insulin resistance in C57BL/6J mice [PDF]

, 2008
Background Obesity and insulin resistance are two major risk factors underlying the metabolic syndrome. The development of these metabolic disorders is frequently studied, but mainly in liver, skeletal muscle, and adipose tissue.
Mechteld M Grootte Bromhaar, Jansen, Jenny, de Groot Philip J, de Groot, P.J., Hooiveld Guido JEJ, Jansen Jenny, Vermeulen, J.J., Nicole JW de Wit, Jansen, J., Müller, M.R., Bosch-Vermeulen, Hanneke, van der Meer, Roelof, de Wit, Nicole J. W., Meer, R., van der, Bromhaar Mechteld, Wit, N.J.W., de, Philip J de Groot, Bosch-Vermeulen Hanneke, Hooiveld, Guido J. E. J., Müller Michael, Müller, Michael, Grootte Bromhaar, M.M., Michael Müller, de Groot, Philip J., Hanneke Bosch-Vermeulen, de Wit Nicole JW, Roelof van der Meer, de Wit, N.J.W., Bromhaar, Mechteld M. Grootte, van der Meer, R., Jenny Jansen, Groot, P.J., de, Guido JEJ Hooiveld, Hooiveld, G.J.E.J., van der Meer Roelof   +34 more
core   +2 more sources

The Role of Tumour Metabolism in Cisplatin Resistance [PDF]

Frontiers in Molecular Biosciences, 2021
Cisplatin is a chemotherapy drug commonly used in cancer treatment. Tumour cells are more sensitive to cisplatin than normal cells. Cisplatin exerts an antitumour effect by interfering with DNA replication and transcription processes. However, the drug-resistance properties of tumour cells often cause loss of cisplatin efficacy and failure of ...
Lude Wang, Xiaoya Zhao, Jianfei Fu, Wenxia Xu, Jianlie Yuan   +4 more
openaire   +3 more sources