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Metabolic mechanisms of immunotherapy resistance
Exploration of Targeted Anti-tumor TherapyImmunotherapy has revolutionized cancer treatment, yet its efficacy is frequently compromised by metabolic mechanisms that drive resistance. Understanding how tumor metabolism shapes the immune microenvironment is essential for developing effective therapeutic strategies. This review examines key metabolic pathways influencing immunotherapy resistance,
Luis Cabezón-Gutiérrez +4 more
openaire +3 more sources
A dose-response strategy reveals differences between normal-weight and obese men in their metabolic and inflammatory responses to a high-fat meal [PDF]
, 2014 A dose-response strategy may not only allow investigation of the impact of foods and nutrients on human health but may also reveal differences in the response of individuals to food ingestion based on their metabolic health status.
Buri, C. +60 more
core +2 more sources
Metabolic syndrome and insulin resistance in migraine [PDF]
The Journal of Headache and Pain, 2012 Metabolic syndrome is associated with migraine but there is no study comparing the characteristics of migraine with and without metabolic syndrome from Southeast Asia. This study was therefore undertaken to compare the clinical characteristics of migraine in patients with and without metabolic syndrome and insulin resistance.
Bhoi, Sanjeev K. +2 more
openaire +2 more sources
, 2019 Aim: To evaluate the association between vitamin D deficiency and insulin resistance (IR) or hyperinsulinemia after oral glucose tolerance test (OGTT) in euthyroid non-diabetic individuals.
Paico Palacios, Socorro +6 more
core +1 more source
Physiological analysis of the metabolic typing diet in professional rugby union players [PDF]
, 2008 Aim: The purpose of this pilot study is to investigate whether the metabolic typing diet warrants further investigation as a tool to design dietary regimes in professional rugby union players.
Braakhuis, A. +3 more
core +1 more source
Fructose, insulin resistance, and metabolic dyslipidemia [PDF]
Nutrition & Metabolism, 2005 Abstract Obesity and type 2 diabetes are occurring at epidemic rates in the United States and many parts of the world. The "obesity epidemic" appears to have emerged largely from changes in our diet and reduced physical activity. An important but not well-appreciated dietary change has been the substantial increase in the amount of dietary ...
Basciano, Heather +2 more
openaire +4 more sources
Deficiency of the bone mineralization inhibitor NPP1 protects against obesity and diabetes [PDF]
, 2014 The emergence of bone as an endocrine regulator has prompted a re-evaluation of the role of bone mineralization factors in the development of metabolic disease.
Elspeth M. Milne +27 more
core +1 more source
MicroRNA, Insulin Resistance, and Metabolic Disorders
International Journal of Molecular Sciences, 2022 Insulin resistance is a significant health problem worldwide that contributes to a number of disorders, including type 2 diabetes and metabolic syndrome [...]
openaire +2 more sources
, 2010 Antimicrobial resistance among clinically important bacteria is widely acknowledged as a major global public health threat. A decade ago, several supranational surveillance initiatives were introduced. Few of them are still ongoing, and only one features
CORNAGLIA, Giuseppe +2 more
core +1 more source
Quantifying the improvement of surrogate indices of hepatic insulin resistance using complex measurement techniques [PDF]
, 2012 We evaluated the ability of simple and complex surrogate-indices to identify individuals from an overweight/obese cohort with hepatic insulin-resistance (HEP-IR).
Martin Osterhoff +35 more
core +2 more sources