Results 21 to 30 of about 873,593 (157)
Cancer Metabolism and Drug Resistance [PDF]
Metabolites, 2015 Metabolic alterations, driven by genetic and epigenetic factors, have long been known to be associated with the etiology of cancer. Furthermore, accumulating evidence suggest that cancer metabolism is intimately linked to drug resistance, which is currently one of the most important challenges in cancer treatment. Altered metabolic pathways help cancer
Mahbuba Rahman, Mohammad Rubayet Hasan
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Metabolic flexibility and insulin resistance
American Journal of Physiology-Endocrinology and Metabolism, 2008 Metabolic flexibility is the capacity for the organism to adapt fuel oxidation to fuel availability. The inability to modify fuel oxidation in response to changes in nutrient availability has been implicated in the accumulation of intramyocellular lipid and insulin resistance.
Galgani Fuentes, José +2 more
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The Role of Tumour Metabolism in Cisplatin Resistance [PDF]
Frontiers in Molecular Biosciences, 2021 Cisplatin is a chemotherapy drug commonly used in cancer treatment. Tumour cells are more sensitive to cisplatin than normal cells. Cisplatin exerts an antitumour effect by interfering with DNA replication and transcription processes. However, the drug-resistance properties of tumour cells often cause loss of cisplatin efficacy and failure of ...
Lude Wang +4 more
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Dinitroaniline Herbicide Resistance and Mechanisms in Weeds
Frontiers in Plant Science, 2021 Dinitroanilines are microtubule inhibitors, targeting tubulin proteins in plants and protists. Dinitroaniline herbicides, such as trifluralin, pendimethalin and oryzalin, have been used as pre-emergence herbicides for weed control for decades.
Jinyi Chen +5 more
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Insecticide resistance in mosquitoes: Development, mechanisms and monitoring
Ceylon Journal of Science, 2018 Mosquito-borne diseases are of major public health concerns, mainly in tropical countries. Control of these diseases is primarily achieved through mosquito control. One of the major challenges encountered by mosquito control programmes is the development
S. H. P. P. Karunaratne +3 more
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Biology, 2022 Pyrethroids are widely applied insecticides in agriculture, but their frequent use has provoked many cases of resistance, in which mutations in the voltage-gated sodium channel (VGSC), the pyrethroid target-site, were shown to play a major role. However,
Berdien De Beer +5 more
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Cholesterol metabolism and resistance to tamoxifen
Current Opinion in Pharmacology, 2012 The oncoprotein MUC-1 was shown to upregulate the transcription of genes encoding cholesterol and lipid metabolic enzymes and correlated with a resistance to Tamoxifen (Tam) despite the presence of estrogen receptor α in breast cancer tumors. The importance of this observation is supported by molecular studies on Tam suggesting two additional ...
Poirot, Marc +2 more
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Julius-Kühn-Archiv, 2022 Die Bekämpfung von Ackerfuchsschwanz (Alopecurus myosuroides Huds.) stellt vor dem Hintergrund der zunehmenden Resistenzen eine Herausforderung dar.
Wagner, Jean, Mücke, Manuela
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Metabolic syndrome and insulin resistance in migraine [PDF]
The Journal of Headache and Pain, 2012 Metabolic syndrome is associated with migraine but there is no study comparing the characteristics of migraine with and without metabolic syndrome from Southeast Asia. This study was therefore undertaken to compare the clinical characteristics of migraine in patients with and without metabolic syndrome and insulin resistance.
Bhoi, Sanjeev K. +2 more
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Origin, mechanism and molecular basis of weed resistance to herbicides
Plant Protection Science, 2004 This review summarises information from the literature and experimental experience of the authors in research on weed resistance to herbicides. Factors conditioning the origin of resistance are described.
Daniela Chodová +3 more
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