Results 31 to 40 of about 3,890,227 (163)
Metabolic vulnerability of cisplatin‐resistant cancers [PDF]
The EMBO Journal, 2018 Cisplatin is the most widely used chemotherapeutic agent, and resistance of neoplastic cells against this cytoxicant poses a major problem in clinical oncology. Here, we explored potential metabolic vulnerabilities of cisplatin-resistant non-small human cell lung cancer and ovarian cancer cell lines.
Florine Obrist +11 more
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Gender, socio-economic status and metabolic syndrome in middle-aged and old adults. [PDF]
, 2008 BACKGROUND: Studies that addressed social and economic determinants of cardiovascular diseases, consistently showed an increase prevalence of the individual features of metabolic syndrome in the lower socio-economic strata.
Barros, Henrique +8 more
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An analogue of piperonyl butoxide facilitates the characterisation of metabolic resistance
, 2009 BACKGROUND: Previous work has demonstrated that piperonyl butoxide (PBO) not only inhibits microsomal oxidases but also resistance-associated esterases. The ability to inhibit both major metabolic resistance enzymes makes it an ideal synergist to enhance
Moores, G. D. +6 more
core +1 more source
Lipid Metabolism and Resistance to Anticancer Treatment [PDF]
Biology, 2020 Metabolic reprogramming is crucial to respond to cancer cell requirements during tumor development. In the last decade, metabolic alterations have been shown to modulate cancer cells’ sensitivity to chemotherapeutic agents including conventional and targeted therapies.
Germain, Nicolas +5 more
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Low Cardiorespiratory Fitness is an Independent Predictor of Metabolic Syndrome in Young Korean Adults [PDF]
, 2008 Objective: To investigate the relationship between cardio/respiratory fitness (CRF) and metabolic syndrome (MS) in young Korean men. Design: In a cross-sectional study, we examined 909 young Korean men (mean±SD age, 24.0±2 years) who were ...
Hyun-Sik Kang, Soo-Hyun Park, Shinuk Kim
core
The interaction between metabolic disease and ageing [PDF]
, 2014 Two of the greatest crises that civilisation faces in the 21st century are the predicted rapid increases in the ageing population and levels of metabolic disorders such as obesity and type 2 diabetes.
Brown, James +7 more
core +1 more source
Metabolic Mechanisms of Drug Resistance in Leukemia [PDF]
Cell Metabolism, 2015 Tumor cells frequently undergo metabolic reprogramming, but it is unknown how these metabolic changes relate to drug resistance. A recent article now demonstrates that PI3K/AKT signaling causes a metabolic switch from glutaminolysis to aerobic glycolysis in Notch-dependent T cell acute lymphoblastic leukemia (T-ALL).
Knoechel, Birgit, Aster, Jon C.
openaire +2 more sources
Genetic variants and the metabolic syndrome: a systematic review [PDF]
, 2011 Several candidate gene studies on the metabolic syndrome (MetS) have been conducted. However, for most single nucleotide polymorphisms (SNPs) no systematic review on their association with MetS exists.
Boer, J.M., Feskens, E.J.M., Povel, C.M.
core +1 more source
Metabolic hallmarks of trastuzumab resistance
Expert Opinion on Therapeutic TargetsThe HER2-targeted monoclonal antibody trastuzumab has significantly improved the survival of patients with HER2-positive breast cancer (HER2+ BC) in both early and metastatic disease. Therapeutic resistance remains an inevitable challenge in the advanced setting, ultimately limiting the long-term efficacy of trastuzumab.
Martin-Castillo, Begoña +5 more
openaire +3 more sources
Metabolic regulation of systemic acquired resistance
Current Opinion in Plant Biology, 2021 Plants achieve an optimal balance between growth and defense by a fine-tuned biosynthesis and metabolic inactivation of immune-stimulating small molecules. Recent research illustrates that three common hubs are involved in the cooperative regulation of systemic acquired resistance (SAR) by the defense hormones N-hydroxypipecolic acid (NHP) and ...
openaire +2 more sources