Results 71 to 80 of about 5,645,921 (292)

Metabolic vulnerability of cisplatin‐resistant cancers [PDF]

The EMBO Journal, 2018
Cisplatin is the most widely used chemotherapeutic agent, and resistance of neoplastic cells against this cytoxicant poses a major problem in clinical oncology. Here, we explored potential metabolic vulnerabilities of cisplatin-resistant non-small human cell lung cancer and ovarian cancer cell lines.
Florine Obrist, Judith Michels, Sylvere Durand, Alexis Chery, Jonathan Pol, Sarah Levesque, Adrien Joseph, Valentina Astesana, Federico Pietrocola, Gen Sheng Wu, Maria Castedo, Guido Kroemer   +11 more
openaire   +2 more sources

Chain formation mediated by Escherichia coli immunoglobulin-binding proteins EibD and EibG depends on expression levels and localization of proteins

Scientific Reports
Escherichia coli expresses immunoglobulin-binding proteins (Eib), a subgroup of trimeric autotransporter adhesins (TAA). Subtypes of Eib proteins mediate unique chain-like adherence patterns and autoaggregation.
Lena-Sophie Swiatek, Katharina Schaufler, Jack C. Leo   +2 more
doaj   +1 more source

A glucose-mediated antibiotic resistance metabolic flux from glycolysis, the pyruvate cycle, and glutamate metabolism to purine metabolism

Frontiers in Microbiology, 2023
IntroductionBacterial metabolic environment influences antibiotic killing efficacy. Thus, a full understanding for the metabolic resistance mechanisms is especially important to combat antibiotic-resistant bacteria.MethodsIsobaric tags for relative and ...
Jiao Xiang, Jiao Xiang, Shi-wen Wang, Yuan Tao, Jing-zhou Ye, Ying Liang, Xuan-xian Peng, Xuan-xian Peng, Xuan-xian Peng, Li-fen Yang, Hui Li, Hui Li   +11 more
doaj   +1 more source

Metabolic Resistance in the Fall Armyworm: An Overview

Journal of Agricultural Sciences, 2018
The Fall Armyworm (FAW), Spodoptera frugiperda (Smith, 1797) (Lepidoptera: Noctuidae), is one of the most important pests in the American continent and has recently become an invasive species in Africa.
I. F. Carvalho, Larissa L. Erdmann, Larissa L. Machado, A. P. S. A. D. Rosa, M. Zotti, Camila G. Neitzke   +5 more
semanticscholar   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Exploring the Molecular Mechanisms of Resistance to Prochloraz by Lasiodiplodia theobromae Isolated from Mango

Journal of Fungi
Mango stem-end rot caused by Lasiodiplodia theobromae is a major postharvest disease in China. Prochloraz is commonly used for disease control in mango orchards and in storage. However, prochloraz resistance has been detected in L. theobromae. This study
Rui He, Jinlin Liu, Pengsheng Li, Yu Zhang, Xiaoyu Liang, Ye Yang   +5 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Metabolic Inflammation and Insulin Resistance in Obesity

Circulation Research, 2020
Supplemental Digital Content is available in the text. Obesity is becoming an epidemic in the United States and worldwide and increases risk for many diseases, particularly insulin resistance, type 2 diabetes mellitus, and cardiovascular disease.
Huaizhu Wu, C. Ballantyne
semanticscholar   +1 more source

Interaction between bacterial adhesins leads to coaggregation by the oral bacteria Veillonella parvula and Streptococcus gordonii

mBio
Veillonella parvula is an unusual diderm firmicute that plays a central role in the formation of dental biofilm formation through coaggregation with many other oral bacteria.
Jack C. Leo
doaj   +1 more source