Results 211 to 220 of about 425,696 (264)
Modifications to 1-(4-(2-Bis(4-fluorophenyl)methyl)sulfinyl)alkyl Alicyclic Amines That Improve Metabolic Stability and Retain an Atypical DAT Inhibitor Profile. [PDF]
J Med ChemOkorom AV +15 more
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Metabolic Stability of Body Constituents
Nature, 1961An appraisal is given of some modern views on the collective metabolism of body constituents in vivo. A working hypothesis, embracing the metabolism of body constituents as a whole, and its influence on both the design and interpretation of metabolic experiments in vivo, is included. (P.C.H.)
A N, DAVISON, J, DOBBING
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STABILITY OF HEPATIC METABOLISM DURING SURGERY
Survey of Anesthesiology, 1964Abstract Using tissue obtained from the liver at open biopsy from forty-three patients at the beginning and again at the close of a surgical procedure, studies of the effect of anesthesia and surgery upon metabolism of the liver have been made. No significant alterations in glutamic-oxaloacetic transaminase (GOT), glutamic-pyruvic transaminase (GPT),
W J, BURDETTE +2 more
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Passive stability in a metabolic network
Journal of Theoretical Biology, 1964Abstract The problem of the stability of cellular systems to environmental changes is reviewed with particular reference to bacteria. Experimental evidence is presented for the range of stability in intermediate metabolism. A model system, “the biochemical vat” is then proposed to study metabolic stability.
H J, Morowitz +3 more
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The metabolic stability of the enkephalins
Biochemical and Biophysical Research Communications, 1977Abstract [Met 5 ] and [Leu 5 ]-enkephalins inhibit 3 H-naloxone binding to brain opiate receptors much more effectively at 4°C than at 25°C. At 25°C several protease inhibitors potentiate the action of the enkephalins. Bacitracin is the most effective of these.
Richard J. Miller +3 more
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Strategies to Enhance Metabolic Stabilities
2019Macrocyclic peptides are a unique class of molecules that display a relatively constrained peptidic backbone as compared to their linear counterparts leading to the defined 3-D orientation of the constituent amino acids (pharmacophore). Although they are attractive candidates for lead discovery owing to the unique conformational features, their ...
Bhavesh, Khatri +2 more
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Metabolic screening in vitro: metabolic stability, CYP inhibition and induction
Drug Discovery Today: Technologies, 2004Automated, miniaturised assays are now commonplace within Discovery DMPK (drug metabolism and pharmacokinetics). These have evolved considerably since their inception around a decade ago, in-line with both technology and the desire to provide quality data comparable to more traditional analyses.
Robert J, Riley, Ken, Grime
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Improving metabolic stability of cancer chemoprotective polyphenols
Expert Opinion on Drug Metabolism & Toxicology, 2007Dietary flavonoids and other polyphenols have the potential to be developed as effective food supplements as well as drugs for the prevention, as well as treatment of, cancer and other disease conditions. However, their very poor oral bioavailability, mainly due to extensive conjugation by glucuronidation and sulfation, is a severe limiting factor ...
Thomas, Walle +2 more
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A Probabilistic Approach to Classifying Metabolic Stability
Journal of Chemical Information and Modeling, 2008Metabolic stability is an important property of drug molecules that should-optimally-be taken into account early on in the drug design process. Along with numerous medium- or high-throughput assays being implemented in early drug discovery, a prediction tool for this property could be of high value.
Anton, Schwaighofer +8 more
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