Results 221 to 230 of about 460,394 (253)

At the Heart of Aging: is it Metabolic Rate or Stability?

Biogerontology, 2005
Foundational changes in science are rare, but in the field of biogerontology there is a new theory of aging that may shake things up. The conventional wisdom about duration of life is based on an old idea known as the "rate of living" theory, which suggests that aging is caused by the loss of some vital substance.
S Jay, Olshansky, Suresh I S, Rattan
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On the stability of equilibria in metabolic feedback systems

Journal of Mathematical Biology, 1985
A sufficient criterion for the stability of the equilibrium of a metabolic feedback system will be constructed.
Berding, Christoph, Haubs, Georg
exaly   +4 more sources

Metabolic screening in vitro: metabolic stability, CYP inhibition and induction

Drug Discovery Today: Technologies, 2004
Automated, miniaturised assays are now commonplace within Discovery DMPK (drug metabolism and pharmacokinetics). These have evolved considerably since their inception around a decade ago, in-line with both technology and the desire to provide quality data comparable to more traditional analyses.
Robert J, Riley, Ken, Grime
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DNA precursor metabolism and genomic stability

The FASEB Journal, 2006
ABSTRACT Intracellular concentrations of the four deoxyribonucleoside triphosphates (dNTPs) are closely regulated, and imbalances in the four dNTP pools have genotoxic consequences. Replication errors leading to mutations can occur, for example, if one dNTP in excess drives formation of a non‐Watson‐Crick base ...
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Improving metabolic stability of cancer chemoprotective polyphenols

Expert Opinion on Drug Metabolism & Toxicology, 2007
Dietary flavonoids and other polyphenols have the potential to be developed as effective food supplements as well as drugs for the prevention, as well as treatment of, cancer and other disease conditions. However, their very poor oral bioavailability, mainly due to extensive conjugation by glucuronidation and sulfation, is a severe limiting factor ...
Thomas, Walle, Xia, Wen, U Kristina, Walle   +2 more
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Metabolic stability of messenger ribonucleoprotein in HeLa cells

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1975
The proteins bound to HeLa cell polyribosomal messenger RNA were isolated by subjecting salt-washed, puromycin-disassembled polyribosomes to a limited digestion with pancreatic ribonuclease (ref. 1, Auerbach, S. and Pederson, T. (1975) Biochem. Biophys. Res. Commun. 63, 149-153). Label-chase experiments with radioactive amino acids revealed that the in
S, Auerbach, T, Pederson
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A metabolic view of the diversity–stability relationship

Journal of Theoretical Biology, 2008
A theoretical analysis of the "portfolio effect" expressed in metabolic terms indicates that the coefficient of variation of total biomass in the ecosystem is influenced by three factors: metabolic diversity, total population size and organism biomass (body mass).
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Metabolism and Excretion of Mood Stabilizers and New Anticonvulsants

Cellular and Molecular Neurobiology, 1999
1. The mood stabilizers lithium, carbamazepine (CBZ), and valproate (VPA), have differing pharmacokinetics, structures, mechanisms of action, efficacy spectra, and adverse effects. Lithium has a low therapeutic index and is renally excreted and hence has renally-mediated but not hepatically-mediated drug-drug interactions. 2.
T A, Ketter, M A, Frye, G, Corá-Locatelli, T A, Kimbrell, R M, Post   +4 more
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Novel CCR1 antagonists with improved metabolic stability

Bioorganic & Medicinal Chemistry Letters, 2004
The synthesis, biological activity, and pharmacokinetic profile of novel CCR1 antagonists are described.
Matthew F, Brown, Mike, Avery, William H, Brissette, J H, Chang, Kevin, Colizza, Maryrose, Conklyn, Amy P, DiRico, Ronald P, Gladue, John C, Kath, Suzanne S, Krueger, Paul D, Lira, Brett M, Lillie, Greg D, Lundquist, Erin N, Mairs, Eric B, McElroy, Molly A, McGlynn, Timothy J, Paradis, Christopher S, Poss, Michelle I, Rossulek, Richard M, Shepard, Jeff, Sims, Timothy J, Strelevitz, Susan, Truesdell, Laurie A, Tylaska, Kwansik, Yoon, Deye, Zheng   +25 more
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Metabolically Stabilized Benzothiazoles for Imaging of Amyloid Plaques

Journal of Medicinal Chemistry, 2007
Six new N-11C-labeled aminophenylbenzothiazoles substituted with fluorine in different positions have been synthesized and evaluated as amyloid-beta binding ligands. Our structure-property relationship studies show that the substitution pattern of the phenyl ring and the benzothiazole moiety has an influence on the metabolic stability, which in turn ...
Gjermund, Henriksen, Andrea I, Hauser, Andrew D, Westwell, Behrooz H, Yousefi, Markus, Schwaiger, Alexander, Drzezga, Hans-Jürgen, Wester   +6 more
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