Results 211 to 220 of about 460,394 (253)

Metabolism of Peptide Drugs and Strategies to Improve their Metabolic Stability

Current Drug Metabolism, 2018
Despite the therapeutic use of peptides is limited because of their metabolism in vivo, there are no systematic reviews explaining degradation of peptides by peptidases. This review summarizes peptidases present in the tissues and metabolic characteristics of peptides, and provides recent strategies for improving the metabolic stability of peptides.We ...
Ming Xue
exaly   +3 more sources

The metabolic stability of the enkephalins

Biochemical and Biophysical Research Communications, 1977
Abstract [Met 5 ] and [Leu 5 ]-enkephalins inhibit 3 H-naloxone binding to brain opiate receptors much more effectively at 4°C than at 25°C. At 25°C several protease inhibitors potentiate the action of the enkephalins. Bacitracin is the most effective of these.
Richard J. Miller, K.-J. Chang, Pedro Cuatrecasas, Sam Wilkinson   +3 more
openaire   +2 more sources

Passive stability in a metabolic network

Journal of Theoretical Biology, 1964
Abstract The problem of the stability of cellular systems to environmental changes is reviewed with particular reference to bacteria. Experimental evidence is presented for the range of stability in intermediate metabolism. A model system, “the biochemical vat” is then proposed to study metabolic stability.
H J, Morowitz, W A, Higinbotham, S W, Matthysse, H, Quastler   +3 more
openaire   +2 more sources

Metabolic Stability of Body Constituents

Nature, 1961
An appraisal is given of some modern views on the collective metabolism of body constituents in vivo. A working hypothesis, embracing the metabolism of body constituents as a whole, and its influence on both the design and interpretation of metabolic experiments in vivo, is included. (P.C.H.)
A N, DAVISON, J, DOBBING
openaire   +2 more sources

A Probabilistic Approach to Classifying Metabolic Stability

Journal of Chemical Information and Modeling, 2008
Metabolic stability is an important property of drug molecules that should-optimally-be taken into account early on in the drug design process. Along with numerous medium- or high-throughput assays being implemented in early drug discovery, a prediction tool for this property could be of high value.
Anton Schwaighofer, Timon Schroeter, Sebastian Mika, Katja Hansen, Antonius ter Laak, Philip Lienau, Andreas Reichel, Nikolaus Heinrich, Klaus-Robert Müller   +8 more
openaire   +2 more sources

Strategies to Enhance Metabolic Stabilities

2019
Macrocyclic peptides are a unique class of molecules that display a relatively constrained peptidic backbone as compared to their linear counterparts leading to the defined 3-D orientation of the constituent amino acids (pharmacophore). Although they are attractive candidates for lead discovery owing to the unique conformational features, their ...
Khatri, Bhavesh, Nuthakki, Venkateswara Rao, Chatterjee, Jayanta   +2 more
openaire   +4 more sources

STABILITY OF HEPATIC METABOLISM DURING SURGERY

Survey of Anesthesiology, 1964
Abstract Using tissue obtained from the liver at open biopsy from forty-three patients at the beginning and again at the close of a surgical procedure, studies of the effect of anesthesia and surgery upon metabolism of the liver have been made. No significant alterations in glutamic-oxaloacetic transaminase (GOT), glutamic-pyruvic transaminase (GPT),
W J, BURDETTE, L E, STEVENS, U, GROESCHEL   +2 more
openaire   +2 more sources

Optimization of metabolic pathways under stability considerations

Computers and Chemical Engineering, 2005
Metabolic networks are often approached through steady-state optimization formulations that are solved to interpret and predict the behavior of the network subject to changes in external fluxes or internal enzyme activity. The major question addressed in this paper is how to ensure that solutions to these steady-state optimization models for metabolic ...
Nikolaos Sahinidis
exaly   +2 more sources

The metabolic stability of ribosomal protein

Molecular and General Genetics MGG, 1967
Measurements of the metabolic stability of ribosomal proteins of exponentially growing Escherichia coli B/r showed that their rate of degradation to free amino acids is zero to within limits of the experimental accuracy of ± 0.7% per hour or ± 0.5% per doubling period.
openaire   +2 more sources

A source of stability in metabolic networks

Journal of Theoretical Biology, 1972
Abstract The generally observed monotonic dependence of enzyme activity on substrate concentration is utilized to give a plausible account of some aspects of the behavior of complex biochemical networks on the “metabolic” time scale. The adduced dynamical equations are shown to prescribe a “canalized” metabolic behavior, in which flow lines in state ...
openaire   +2 more sources