Results 221 to 230 of about 425,696 (264)
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Novel CCR1 antagonists with improved metabolic stability
Bioorganic & Medicinal Chemistry Letters, 2004The synthesis, biological activity, and pharmacokinetic profile of novel CCR1 antagonists are described.
Matthew F, Brown +25 more
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DNA precursor metabolism and genomic stability
The FASEB Journal, 2006ABSTRACT Intracellular concentrations of the four deoxyribonucleoside triphosphates (dNTPs) are closely regulated, and imbalances in the four dNTP pools have genotoxic consequences. Replication errors leading to mutations can occur, for example, if one dNTP in excess drives formation of a non‐Watson‐Crick base ...
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The metabolic stability of ribosomal protein
Molecular and General Genetics MGG, 1967Measurements of the metabolic stability of ribosomal proteins of exponentially growing Escherichia coli B/r showed that their rate of degradation to free amino acids is zero to within limits of the experimental accuracy of ± 0.7% per hour or ± 0.5% per doubling period.
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Metabolism of Peptide Drugs and Strategies to Improve their Metabolic Stability
Current Drug Metabolism, 2018Despite the therapeutic use of peptides is limited because of their metabolism in vivo, there are no systematic reviews explaining degradation of peptides by peptidases. This review summarizes peptidases present in the tissues and metabolic characteristics of peptides, and provides recent strategies for improving the metabolic stability of peptides.We ...
Jin-Feng, Yao +3 more
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Metabolic regulation of genome stability
Science, 2017DNA Replication Cells respond to metabolic fluctuations by adjusting the speed of DNA replication as a safeguard for genome stability. Somyajit et al. elucidate the cellular mechanisms that align replication fork dynamics with metabolic pathways (see the Perspective by Gomez-Gonzalez and Aguilera).
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Stability and Drug Metabolism Assessed by Electrochemical Methods
Combinatorial Chemistry & High Throughput Screening, 2010This review is focused on the use of the electrochemical techniques, voltammetry and polarography, as well as biosensors, for the study of drug stability. In addition, this review also details the study of drug metabolism by electrochemistry and mass spectrometry.
Alejandro, Alvarez-Lueje, Soledad, Bollo
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A source of stability in metabolic networks
Journal of Theoretical Biology, 1972Abstract The generally observed monotonic dependence of enzyme activity on substrate concentration is utilized to give a plausible account of some aspects of the behavior of complex biochemical networks on the “metabolic” time scale. The adduced dynamical equations are shown to prescribe a “canalized” metabolic behavior, in which flow lines in state ...
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CYP2C9 Structure−Metabolism Relationships: Optimizing the Metabolic Stability of COX-2 Inhibitors
Journal of Medicinal Chemistry, 2007The cytochrome P450 (CYP) family is composed of a large group of monooxygenases that mediate the metabolism of xenobiotics and endogenous compounds. CYP2C9, one of the major isoforms of the CYP family, is responsible for the phase I metabolism of a variety of drugs.
Marie M, Ahlström +3 more
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What determines longevity: Metabolic rate or stability?
Discovery medicine, 2005Extract: The conventional wisdom about why species age and live as long as they do is based in part on the modern version of the very old and now discredited "rate of living" (ROL) theory of aging. According to the old ROL theory, aging is caused by the loss of some vital substance such as water or hormones - the more rapid the vital substance is used ...
Olshansky, S.J., Rattan, Suresh
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Adrenomedullin 2.0: Adjusting Key Levers for Metabolic Stability
Journal of Medicinal Chemistry, 2016The 52 amino acid peptide hormone adrenomedullin (ADM) plays a major role in the development and regulation of the cardiovascular and lymphatic system and has therefore gained significant interest for clinical applications. Because adrenomedullin exhibits low metabolic stability, enhancement of the plasma half-life is essential for peptide-based drug ...
Ria, Schönauer +5 more
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