Natriuretic peptides and cardiovascular damage in the metabolic syndrome. Molecular mechanisms and clinical implications [PDF]
Natriuretic peptides are endogenous antagonists of vasoconstrictor and salt- and water-retaining systems in the body's defence against blood pressure elevation and plasma volume expansion, through direct vasodilator, diuretic and natriuretic properties ...
ALONZO, ALESSANDRO+4 more
core +1 more source
Microbiome as a biomarker and therapeutic target in pancreatic cancer
Studying the effects of the microbiome on the development of different types of cancer has recently received increasing research attention. In this context, the microbial content of organs of the gastrointestinal tract has been proposed to play a ...
Ghazaleh Pourali+13 more
doaj +1 more source
B cell metabolism in autoimmune diseases: signaling pathways and interventions
Autoimmune diseases are heterogeneous disorders believed to stem from the immune system’s inability to distinguish between auto- and foreign- antigens.
Jingyue Li+7 more
doaj +1 more source
Semi-Supervised Deep Learning for Multi-Tissue Segmentation from Multi-Contrast MRI [PDF]
Segmentation of thigh tissues (muscle, fat, inter-muscular adipose tissue (IMAT), bone, and bone marrow) from magnetic resonance imaging (MRI) scans is useful for clinical and research investigations in various conditions such as aging, diabetes mellitus, obesity, metabolic syndrome, and their associated comorbidities. Towards a fully automated, robust,
arxiv +1 more source
CD226+CD8+ T cells express elevated levels of RUNX2, exhibit higher proliferation capacity, cytokines and cytolytic molecules expression, and migratory capacity. In contrast, CD226−CD8+ T cells display an exhausted phenotype associated with the increased expression of co‐inhibitory receptors and impaired effector functions.
Maryam Rezaeifar+4 more
wiley +1 more source
The metabolic syndrome adds utility to the prediction of mortality over its components: The Vietnam Experience Study [PDF]
Background\ud The metabolic syndrome increases mortality risk. However, as “non-affected” individuals may still have up to two risk factors, the utility of using three or more components to identify the syndrome, and its predictive advantage over ...
Anna C. Phillips+24 more
core +1 more source
Chemical analysis of atherosclerotic plaque cholesterol combined with histology of the same tissue
Sensitive method for chemical analysis of free cholesterol (FC) and cholesterol esters (CE) was developed. Mouse arteries were dissected and placed in chloroform-methanol without tissue grinding.
Ming-Shang Kuo+8 more
doaj
The prevalence of obesity increases worldwide. Treating obesity and its associated health problems has a significant economic impact on health care systems.
Marcio C. Mancini, Maria Edna de Melo
doaj +1 more source
Using runs of homozygosity to detect genomic regions associated with susceptibility to infectious and metabolic diseases in dairy cows under intensive farming conditions [PDF]
Runs of homozygosity (ROH) are contiguous stretches of homozygous genome which likely reflect transmission from common ances- tors and can be used to track the inheritance of haplotypes of interest. In the present paper, ROH were extracted from 50K SNPs and used to detect regions of the genome associated with susceptibility to diseases in a population ...
arxiv
The shape of health: A comparison of five alternative ways of visualizing personal health and wellbeing [PDF]
The combination of clinical and personal health and wellbeing data can tell us much about our behaviors, risks and overall status. The way this data is visualized may affect our understanding of our own health. To study this effect, we conducted a small experiment with 30 participants in which we presented a holistic overview of the health and ...
arxiv +1 more source