Results 121 to 130 of about 6,426,940 (341)

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

The Circadian Syndrome: is the Metabolic Syndrome and much more!

Journal of Internal Medicine, 2019
The Metabolic Syndrome is a cluster of cardio‐metabolic risk factors and comorbidities conveying high risk of both cardiovascular disease and type 2 diabetes.
P. Zimmet, K. Alberti, N. Stern, C. Bilu, A. El-Osta, H. Einat, N. Kronfeld-Schor   +6 more
semanticscholar   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Impaired Aryl Hydrocarbon Receptor Ligand Production by the Gut Microbiota Is a Key Factor in Metabolic Syndrome.

Cell Metabolism, 2018
The extent to which microbiota alterations define or influence the outcome of metabolic diseases is still unclear, but the byproducts of microbiota metabolism are known to have an important role in mediating the host-microbiota interaction.
J. Natividad, Allison Agus, J. Planchais, B. Lamas, A. Jarry, Rebeca Martín, Marie‐Laure Michel, C. Chong-Nguyen, R. Roussel, M. Straube, S. Jégou, Claire Mcquitty, M. le Gall, G. da Costa, Emmanuelle Lecornet, C. Michaudel, Morgane Modoux, Jérémy Glodt, C. Bridonneau, B. Sovran, L. Dupraz, A. Bado, Mathias L. Richard, P. Langella, B. Hansel, J. Launay, R. Xavier, H. Duboc, H. Sokol   +28 more
semanticscholar   +1 more source

A Low Psoas Muscle Index Was Associated With a Poorer Overall Survival in Patients Who Underwent Percutaneous Nephrostomy

Aging and Cancer, EarlyView.
In patients with malignant ureteral obstruction undergoing percutaneous nephrostomy, sarcopenia defined by a low psoas muscle index was independently associated with poor overall survival on multivariate Cox regression analysis, suggesting that preoperative assessment of psoas muscle index may aid prognostic stratification in this population.
Kota Shimokihara, Takashi Kawahara, Kazuhide Makiyama, Hiroji Uemura   +3 more
wiley   +1 more source

Reply to: vitamin D supplementation and hemoglobin: dosing matters in prevention/treatment of anemia

Nutrition Journal, 2021
Seyyed Mostafa Arabi, Golnaz Ranjbar, Leila Sadat Bahrami, Abdolreza Norouzy   +3 more
doaj   +1 more source

The relationship between serum irisin levels and renal function in patients with type 2 diabetes mellitus [PDF]

Caspian Journal of Internal Medicine
Background: Irisin, a myokine implicated in metabolic hemostasis, have been investigated in relation to type 2 diabetes mellitus (T2DM), yet findings on its serum levels and association with diabetic complications such as nephropathy remain inconsistent.
Robab Beigom Aboutorabi, Golrokh Hariri, Zahra Mazloum Khorasani, Hassan Mehrad-Majd   +3 more
doaj  

The diagnostic and prognostic value of C1orf174 in colorectal cancer [PDF]

BioImpacts
Introduction: Colorectal cancer (CRC) is among the lethal cancers, indicating the need for the identification of novel biomarkers for the detection of patients in earlier stages.
Elham Nazari, Ghazaleh Khalili-Tanha, Ghazaleh Pourali, Fatemeh Khojasteh-Leylakoohi, Hanieh Azari, Mohammad Dashtiahangar, Hamid Fiuji, Zahra Yousefli, Alireza Asadnia, Mina Maftooh, Hamed Akbarzade, Mohammadreza Nassiri, Seyed Mahdi Hassanian, Gordon A Ferns, Godefridus J Peters, Elisa Giovannetti, Jyotsna Batra, Majid Khazaei, Amir Avan   +18 more
doaj   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source

Microbiota and Metabolic Syndrome

Turk Kardiyoloji Dernegi Arsivi-Archives of the Turkish Society of Cardiology, 2017
The role of gut bacteria in the pathogenesis and treatment of various diseases has been a focus of attention in the last 10 years. Prevalence of diabetes, obesity, and cardiovascular diseases continues to increase, in spite of technological developments and treatment alternatives.
Yüksel Altuntaş, Adnan Batman
openaire   +3 more sources