Results 101 to 110 of about 6,426,940 (341)

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Increased Prevalence of Metabolic Syndrome in Patients with Psoriatic Arthritis

, 2014
Objective: The increased incidence of cardiovascular disease (CVD) in patients with psoriatic arthritis (PsA) has been reported previously. We aimed to evaluate the presence of metabolic syndrome and to assess the insulin resistance associated with ...
Bahadir, Cengiz, Pehlevan, Yekta, Pehlevan, Seval, Goktay, Fatih, Ince, Nurhan, Yetkin, Demet Ozgil, Kayatas, Kadir   +6 more
core   +1 more source

CURRENT RECOMMENDATIONS ON RISK STRATIFICATION AND SUDDEN CARDIAC DEATH PREVENTION IN PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY (BASED ON THE 2011 RECOMMENDATIONS BY THE AMERICAN COLLEGE OF CARDIOLOGY / AMERICAN HEART ASSOCIATION)

Кардиоваскулярная терапия и профилактика, 2013
One of the clinical scenarios of hypertrophic cardiomyopathy (HCMP) is sudden cardiac death (SCD). The stratification of SCD risk is the key component of defining the therapeutic strategy in HCMP patients.
E. V. Privalova, V. Yu. Kaplunova, N. V. Khabarova, G. A. Shakaryants, Yu. N. Belenkov   +4 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Metabolic Syndrome Criteria As Predictors of Insulin Resistance, Inflammation and Mortality in Chronic Hemodialysis Patients

, 2014
Background: Chronic kidney disease (CKD) and metabolic syndrome are characterized by overlapping disorders, including glucose intolerance, hypertension, dyslipidemia, and, in some cases, obesity.
Minicucci, Marcos Ferreira [UNESP], Caramori, Jacqueline Socorro Costa Teixeira [UNESP], Vogt, Barbara Perez [UNESP], Souza, Priscilla L. [UNESP], Martin, Luis Cuadrado [UNESP], Vogt, Barbara Perez, Martin, Luis Cuadrado, Barretti, Pasqual [UNESP], Minicucci, Marcos Ferreira, Caramori, Jacqueline Socorro Costa Teixeira, Souza, Priscilla L., Barretti, Pasqual   +11 more
core   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

The burden of obesity in the current world and the new treatments available: focus on liraglutide 3.0 mg

Diabetology & Metabolic Syndrome, 2017
The prevalence of obesity increases worldwide. Treating obesity and its associated health problems has a significant economic impact on health care systems.
Marcio C. Mancini, Maria Edna de Melo
doaj   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Comparison of Anthropometric Indices in Predicting Metabolic Syndrome Components in Children

, 2011
Background: The International Diabetes Federation (IDF) defines metabolic syndrome among children. In addition to the abdominal obesity (waist circumference 90 percentile of locally representative sample), the risk criteria for metabolic syndrome ...

core   +1 more source

Metabolic syndrome, the leptin gene and kidney disease in non-diabetic black South Africans [PDF]

, 2008
Includes abstract.Includes bibliographical references (leaves 226-256).Obesity is a worldwide problem and is a factor in the pathogenesis of the metabolic syndrome and kidney disease through the development of obesity-related hypertension and ...
Okpechi, Ikechi Gareth
core   +1 more source