Results 111 to 120 of about 5,570,553 (408)

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Nutrient Inadequacy Rates Among Japanese Adolescents Aged 10–14: Cross-Sectional Pooled Analysis From 2018 to 2023 (NICE EVIDENCE Study 5)

Journal of Nutrition and Metabolism
This study aimed to describe the demographics, nutrient and food group intakes, and adherence to dietary guidelines among Japanese adolescents aged 10–14 years.
Efrem d’Avila Ferreira, Sakiko Yoshizawa Morikawa, Yasunaga Takeda, Izumi Ikeda, Risa Igarashi Matsumoto, Mizuki Takeuchi, Mariko Hatta, Chika Horikawa, Laymon Khin, Hajime Ishiguro, Kazuya Fujihara, Yohei Ogawa, Hirohito Sone   +12 more
doaj   +1 more source

Changes in the microsomal proteome of tomato fruit during ripening [PDF]

, 2019
The variations in the membrane proteome of tomato fruit pericarp during ripening have been investigated by mass spectrometry-based label-free proteomics.
De Lorenzo, Giulia, Fabbri, Claudia, Licursi, Valerio, Mattei, Benedetta, Negri, Rodolfo, Pontiggia, Daniela, Spinelli, Francesco   +6 more
core   +1 more source

Molecular Functions and Pathways of Plastidial Starch Phosphorylase (PHO1) in Starch Metabolism: Current and Future Perspectives [PDF]

, 2021
Noman Shoaib, Lun Liu, Asif Ali, Nishbah Mughal, Guowu Yu, Yubi Huang   +5 more
openalex   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Cytoplasmic p53 couples oncogene-driven glucose metabolism to apoptosis and is a therapeutic target in glioblastoma. [PDF]

, 2017
Cross-talk among oncogenic signaling and metabolic pathways may create opportunities for new therapeutic strategies in cancer. Here we show that although acute inhibition of EGFR-driven glucose metabolism induces only minimal cell death, it lowers the ...
A Magi, AM Spence, Anthony Letai, AV Follis, AV Vaseva, BA Tannous, BJ Altman, Brian Higgins, C Tovar, CW Brennan, D Jiang, D Nathanson, DA Nathanson, DA Reardon, David A Nathanson, DR Green, E Cerami, E Strom, E Tasdemir, EH Cheng, EQ Lee, G Lessene, H Dai, H Takanaga, Harley I Kornblum, I Babic, I Vivanco, J Deng, J Gao, J Lee, J Lehár, J Montero, J Pomerantz, Jason T Lee, JC Liu, JE Chipuk, JE Chipuk, JE Chipuk, JIJ Leu, Jonathan E Tsang, JP Kruse, K Masui, L Qu, Laura Gosa, Lisa Ta, M Mihara, M-K Han, MG Vander Heiden, Mitra Dehghan Harati, MJ Lee, Nicholas A Bayley, OD Maddocks, P Nagesh Rao, Paul S Mischel, Peter M Clark, PM Clark, PY Wen, Q Ding, R Haq, RGW Verhaak, RJ DeBerardinis, Steven J Bensinger, TF Cloughesy, Timothy F Cloughesy, Veerle W Daniels, W Blake Gilmore, W Wei, WH Yang, William H Yong, Wilson X Mai, Y Zhang, Y Zhao   +71 more
core   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Systems biology analysis of drivers underlying hallmarks of cancer cell metabolism. [PDF]

, 2017
Malignant transformation is often accompanied by significant metabolic changes. To identify drivers underlying these changes, we calculated metabolic flux states for the NCI60 cell line collection and correlated the variance between metabolic states of ...
Bordbar, Aarash, Corbett, Austin J, Jamshidi, Neema, Palsson, Bernhard O, Thomas, Alex, Zielinski, Daniel C   +5 more
core   +1 more source

Water Metabolism [PDF]

Anaesthesia and Intensive Care, 1977
Total body water is finely regulated and controls of intake and output are maximally activated by small osmotic changes. Sensors in the hypothalamus invoke the fluid repletion or depletion reactions through changes in thirst, urine concentration and solute intake.
openaire   +2 more sources

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source