Results 111 to 120 of about 4,144,108 (357)

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi, Eric Feng, Nicholas R. Rydzewski, Amy K. Taylor, Jamie M. Sperger, Yue Shi, Kyle T. Helzer, Matthew L. Bootsma, Viridiana Carreno, Alex H. Chang, Luke A. Nunamaker, Grace C. Blitzer, Tianfu Andy Shang, Aishwarya Subramanian, Anders Bjartell, Andreas Josefsson, Pernilla Wikström, Emily Feng, Manish Kohli, Rendong Yang, Scott M. Dehm, Eric J. Small, Rahul Aggarwal, David A. Quigley, Joshua M. Lang, Shuang G. Zhao, Martin Sjöström   +26 more
wiley   +1 more source

Splanchnic metabolism of nutrients and hormones in steers fed alfalfa under conditions of increased absorption of ammonia and L-arginine supply across the portal-drained viscera [PDF]

, 2005
Effects of increased ammonia and/or arginine absorption on net splanchnic (portal-drained viscera [PDV] plus liver) metabolism of nonnitrogenous nutrients and hormones in cattle were examined.
Assan, Bergman, Bruggemann, C. K. Reynolds, Chalupa, D. E. Beever, Davenport, Davenport, Demigne, Elsasser, Fernandez, Gow, Hammerman, Huntington, Krebs, Kuhara, Lobley, Lobley, M. A. Lomax, Maltby, Meijer, Milano, Morgan, Newsholme, Prior, Prior, Reynolds, Reynolds, Reynolds, Reynolds, Reynolds, Reynolds, Reynolds, Reynolds, S. A. Maltby, Seal, Spires, Taniguchi, Titheradge, Tyrrell, Vicini, Visek, Waterlow   +42 more
core   +1 more source

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

Metabolism and headache [PDF]

The Journal of Headache and Pain, 2015
Background In the past decade, several studies have shown a significant association between migraine and several features of the metabolic syndrome (MetS), including insulin resistance, systemic hypertension, and obesity. In addition, headache is a highly prevalent symptom in several metabolic disorders. The purpose of this review was to discuss recent
openaire   +4 more sources

Advanced Glycation End Products, Advanced Oxidation Protein Products, and Ferric Reducing Ability of Plasma Are Correlates of Uncontrolled Hypertension in Patients With Type 2 Diabetes

Journal of Diabetes Research
Conclusion: Oxidative stress indices are associated with HTN status and correlated with uncontrolled HTN in populations with T2D.
Seyed Arsalan Seyedi, Reihane Qahremani, Samira Amin Afshari, Armin Rajab, Amirhossein Yadegar, Fatemeh Mohammadi, Mostafa Shomalzadeh, Sahar Karimpour Reyhan, Hossein Mirmiranpour, Soghra Rabizadeh, Alireza Esteghamati, Manouchehr Nakhjavani   +11 more
doaj   +1 more source

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

Molecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé, Lisa Hahnefeld, Katharina J. Wenger, Donat Kögel, Joachim Steinbach, Gerd Geisslinger, Michael W. Ronellenfitsch, Irmgard Tegeder   +7 more
wiley   +1 more source

Nonalcoholic Fatty Liver Disease as a Potential Risk Factor for Cardiovascular Disease in Patients with Type 2 Diabetes: A Prospective Cohort Study

International Journal of Endocrinology
Background and Objectives. Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disorder in western countries. Although the etiology of NAFLD is unknown, insulin resistance is a key mechanism of lipid deposition in hepatocytes ...
Mohammad Dehghani Firouzabadi, Amirhossein Poopak, Ali Sheikhy, Fatemeh Dehghani Firouzabadi, Fatemeh Moosaie, Soghra Rabizadeh, Sara Momtazmanesh, Manouchehr Nakhjavani, Alireza Esteghamati   +8 more
doaj   +1 more source

GeneFishing to reconstruct context specific portraits of biological processes. [PDF]

, 2019
Rapid advances in genomic technologies have led to a wealth of diverse data, from which novel discoveries can be gleaned through the application of robust statistical and computational methods.
Ashuach, Tal, Bickel, Peter J, Dose, Andrea C, Huang, Haiyan, Liu, Ke, Medina, Marisa W, Theusch, Elizabeth, Zhou, Yun   +7 more
core   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Metabolism disrupting chemicals and metabolic disorders

Reproductive Toxicology, 2017
The recent epidemics of metabolic diseases, obesity, type 2 diabetes(T2D), liver lipid disorders and metabolic syndrome have largely been attributed to genetic background and changes in diet, exercise and aging. However, there is now considerable evidence that other environmental factors may contribute to the rapid increase in the incidence of these ...
Heindel, Jerrold J, Blumberg, Bruce, Cave, Mathew, Machtinger, Ronit, Mantovani, Alberto, Mendez, Michelle A, Nadal, Angel, Palanza, Paola, PANZICA, Giancarlo, Sargis, Robert, Vandenberg, Laura N, Vom Saal, Frederick   +11 more
openaire   +5 more sources