Results 121 to 130 of about 5,419,102 (403)

Fibroblast-Like Synoviocytes Glucose Metabolism as a Therapeutic Target in Rheumatoid Arthritis. [PDF]

, 2019
Metabolomic studies show that rheumatoid arthritis (RA) is associated with metabolic disruption that may be therapeutically targetable. Among them, glucose metabolism and glycolytic intermediaries seem to have an important role in fibroblast-like ...
de Oliveira, Patricia Gnieslaw, Farinon, Mirian, Guma, Monica, Miyamoto, Shigeki, Sanchez-Lopez, Elsa   +4 more
core   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Insights into the Ecological Roles and Evolution of Methyl-Coenzyme M Reductase-Containing Hot Spring Archaea [PDF]

, 2019
Several recent studies have shown the presence of genes for the key enzyme associated with archaeal methane/alkane metabolism, methyl-coenzyme M reductase (Mcr), in metagenome-assembled genomes (MAGs) divergent to existing archaeal lineages.
Chen, Ya-Ting, Evans, Paul N., Goh, Kian Mau, Hedlund, Brian P., Hozzein, Wael, Hua, Zheng-Shuang, Huang, Min-Jun, Jiao, Jian-Yu, Li, Wen-Jun, Li, Yu-Xian, Mao, Yan-Ping, Qi, Yan-Ling, Qu, Yan-Ni, Rao, Yang-Zhi, Shu, Wen-Sheng, Tyson, Gene W., Wang, Yu-Lin, Zhang, Tong   +17 more
core   +2 more sources

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Metabolism disrupting chemicals and metabolic disorders

Reproductive Toxicology, 2017
The recent epidemics of metabolic diseases, obesity, type 2 diabetes(T2D), liver lipid disorders and metabolic syndrome have largely been attributed to genetic background and changes in diet, exercise and aging. However, there is now considerable evidence that other environmental factors may contribute to the rapid increase in the incidence of these ...
Heindel, Jerrold J, Blumberg, Bruce, Cave, Mathew, Machtinger, Ronit, Mantovani, Alberto, Mendez, Michelle A, Nadal, Angel, Palanza, Paola, PANZICA, Giancarlo, Sargis, Robert, Vandenberg, Laura N, Vom Saal, Frederick   +11 more
openaire   +5 more sources

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

The Case of Dinosaur Metabolism [PDF]

, 2017
In lieu of an abstract, here is the article\u27s first paragraph: To learn the critical skill of scientific argumentation, students need learning experiences that involve constructing evidence-based explanations.
Llewellyn, Douglas, Ullock, Caitlin
core   +1 more source

Metabolic-Bariatric Surgery: An Emerging Specialty

Proceedings of Singapore Healthcare, 2012
After the end of the second world war, the world saw a significant period of growth and prosperity unlike any previously. By the 1950s, morbid obesity was proving to be a clinical problem in many developed societies in Europe and North America.
S Pasupathy MBBS, FRCS (Ed), FRCS (Glas), Kwang Wei Tham MB, BCh, BAO, ABIM (Endocrinology, Diabetes and Metabolism)   +1 more
doaj   +1 more source

The metabolism of nitrogen, calcium and phosphorus in undernourished children [PDF]

, 1957
Kantha Joseph, M. Narayanarao, M. Swaminathan, V. Subrahmanyan   +3 more
openalex   +1 more source

Tryptophan metabolism in health and disease.

Cell Metabolism, 2023
Chen Xue, Ganglei Li, Q. Zheng, Xin-yu Gu, Qing-miao Shi, Yuanshuai Su, Qingfei Chu, Xin Yuan, Zhengyi Bao, Juan-fen Lu, Lanjuan Li   +10 more
semanticscholar   +1 more source