Results 121 to 130 of about 5,570,553 (408)

Factors affecting ammonium uptake in streams - an inter-biome perspective [PDF]

, 2003
The Lotic Intersite Nitrogen experiment (LINX) was a coordinated study of the relationships between North American biomes and factors governing ammonium uptake in streams. Our objective was to relate inter-biome variability of ammonium uptake to physical,
Bowden, William B., Dahm, Clifford N., Dodds, Walter K., Findlay, Stuart, Gregory, Stanley V., Grimm, Nancy B., Hamilton, Stephen K., Johnson, Sherri L., Marti, Eugenia, McDowell, William H., Meyer, Judy L., Morrall, Donna D., Mulholland, Patrick J., Peterson, Bruce J., Tanks, Jennifer L., Thomas, Steven A., Valett, H. Maurice, Webster, Jackson R., Wollheim, Wilfred M.   +18 more
core   +1 more source

Remnants of an ancient metabolism without phosphate [PDF]

, 2017
Phosphate is essential for all living systems, serving as a building block of genetic and metabolic machinery. However, it is unclear how phosphate could have assumed these central roles on primordial Earth, given its poor geochemical accessibility.
Goldford, Joshua E., Hartman, Hyman, Segrè, Daniel, Smith, Temple F.   +3 more
core   +1 more source

Reprogramming of fatty acid metabolism in cancer

British Journal of Cancer, 2019
A common feature of cancer cells is their ability to rewire their metabolism to sustain the production of ATP and macromolecules needed for cell growth, division and survival.
Nikos Koundouros, G. Poulogiannis
semanticscholar   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

The key role of nitric oxide in hypoxia: hypoxic vasodilation and energy supply-demand matching [PDF]

, 2013
Significance: a mismatch between energy supply and demand induces tissue hypoxia with the potential to cause cell death and organ failure. Whenever arterial oxygen concentration is reduced, increases in blood flow - 'hypoxic vasodilation' - occur in an ...
Alex Dyson, Audibert G, Berne RM, Blitzer ML, Boutilier RG, Brown IP, Devlin C, Furukawa K, Hall JE, Heyes MP, Jekabsone A, Lehninger A, Leone AM, Louis CA, Martin Feelisch, Mervyn Singer, Michele Umbrello, Modin A, Munk VC, Pohl U, Rengasamy A, Rengasamy A, Vallance P, Whorton AR   +23 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Advanced Glycation End Products, Advanced Oxidation Protein Products, and Ferric Reducing Ability of Plasma Are Correlates of Uncontrolled Hypertension in Patients With Type 2 Diabetes

Journal of Diabetes Research
Conclusion: Oxidative stress indices are associated with HTN status and correlated with uncontrolled HTN in populations with T2D.
Seyed Arsalan Seyedi, Reihane Qahremani, Samira Amin Afshari, Armin Rajab, Amirhossein Yadegar, Fatemeh Mohammadi, Mostafa Shomalzadeh, Sahar Karimpour Reyhan, Hossein Mirmiranpour, Soghra Rabizadeh, Alireza Esteghamati, Manouchehr Nakhjavani   +11 more
doaj   +1 more source

Computational reconstruction of tissue‐specific metabolic models: application to human liver metabolism [PDF]

, 2010
Livnat Jerby, Tomer Shlomi, Eytan Ruppin
openalex   +1 more source

Glucose Metabolism Disorders: Challenges and Opportunities for Diagnosis and Treatment [PDF]

, 2022
Jelena Vekić, José Silva‐Nunes, Manfredi Rizzo   +2 more
openalex   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source