Results 151 to 160 of about 5,570,553 (408)

Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease

Cell, 2017
B. Stockwell, J. Angeli, H. Bayır, A. Bush, M. Conrad, S. Dixon, S. Fulda, S. Gascón, Stavroula K. Hatzios, V. Kagan, Kay Noel, Xuejun Jiang, A. Linkermann, M. Murphy, M. Overholtzer, Atsushi Oyagi, G. Pagnussat, Jason Park, Qitao Ran, C. Rosenfeld, K. Salnikow, Daolin Tang, Daolin Tang, F. Torti, S. Torti, S. Toyokuni, K. Woerpel, Donna D. Zhang   +27 more
semanticscholar   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Matcha green tea (MGT) inhibits the propagation of cancer stem cells (CSCs), by targeting mitochondrial metabolism, glycolysis and multiple cell signalling pathways [PDF]

, 2018
Gloria Bonuccelli, Federica Sotgia, Michael P. Lisanti   +2 more
openalex   +1 more source

The Emerging Hallmarks of Cancer Metabolism.

Cell Metabolism, 2016
N. Pavlova, C. Thompson
semanticscholar   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Deaths from Acute Respiratory Infections are Linked to High Fasting Blood Glucose and Decreased Levels of Low-Density Lipoprotein/Small Dense Low-Density Lipoprotein

International Journal of General Medicine
Li Li,1 Wei Du,1 Jing Song,1 Ye Lu,1 Jing Wan,1 Wenjie Wang,1 Yunhai Feng,2 Jun Yin1,3,4 1Department of Endocrinology and Metabolism, Shanghai Eighth People’s Hospital, Shanghai, People’s Republic of China; 2Department of Otolaryngology, Head and Neck ...
Li L, Du W, Song J, Lu Y, Wan J, Wang W, Feng Y, Yin J   +7 more
doaj  

Subjective–Objective Sleep Discrepancy Is Associated With Alterations in Regional Glucose Metabolism in Patients With Insomnia and Good Sleeper Controls [PDF]

, 2017
Daniel B. Kay, Helmet T. Karim, Adriane M. Soehner, Brant P. Hasler, Jeffrey A. James, Anne Germain, Martica H. Hall, Peter L. Franzen, Julie C. Price, Eric A. Nofzinger, Daniel J. Buysse   +10 more
openalex   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Kinetic modeling of hyperpolarized ¹³C pyruvate metabolism in tumors using a measured arterial input function [PDF]

, 2012
Samira M. Kazan, Steven Reynolds, Aneurin J. Kennerley, Emily G. Wholey, J. E. Bluff, Jason Berwick, Vincent J. Cunningham, Martyn N.J. Paley, Gillian M. Tozer   +8 more
openalex   +1 more source

Environmental Response to Root Secondary Metabolite Accumulation in Paeonia lactiflora: Insights from Rhizosphere Metabolism and Root-Associated Microbial Communities

, 2022
Xiao Sun, Xinke Zhang, Guoshuai Zhang, Yujing Miao, Tiexin Zeng, Min Zhang, Huihui Zhang, Lı Zhang, Linfang Huang   +8 more
openalex   +1 more source