Results 81 to 90 of about 5,150,728 (333)
Cytochrome P450 Enzymes and Drug Metabolism in Humans
International Journal of Molecular Sciences, 2021 Human cytochrome P450 (CYP) enzymes, as membrane-bound hemoproteins, play important roles in the detoxification of drugs, cellular metabolism, and homeostasis. In humans, almost 80% of oxidative metabolism and approximately 50% of the overall elimination
Mingzhe Zhao +10 more
semanticscholar +1 more source
Cytochrome P450 CYP1B1 interacts with 8-methoxypsoralen (8-MOP) and influences psoralen-Ultraviolet A (PUVA) sensitivity [PDF]
, 2013 Background: There are unpredictable inter-individual differences in sensitivity to psoralen-UVA (PUVA) photochemotherapy, used to treat skin diseases including psoriasis.
Deeni, Yusuf Y. +4 more
core +3 more sources
Communications Biology, 2021 Kato, Abdollahi et al. identify a redox protein thioredoxin and mitochondrial fission-1 (FIS1) protein as miR-379 targets in mouse kidney. They find that miR-379 knockout mice are protected from diabetic kidney disease by enhancing mitophagy via FIS1 ...
Mitsuo Kato +14 more
doaj +1 more source
Gut microbiota functions: metabolism of nutrients and other food components
European Journal of Nutrition, 2017 The diverse microbial community that inhabits the human gut has an extensive metabolic repertoire that is distinct from, but complements the activity of mammalian enzymes in the liver and gut mucosa and includes functions essential for host digestion. As
I. Rowland +6 more
semanticscholar +1 more source
The compositional and evolutionary logic of metabolism
, 2012 Metabolism displays striking and robust regularities in the forms of modularity and hierarchy, whose composition may be compactly described. This renders metabolic architecture comprehensible as a system, and suggests the order in which layers of that ...
Alberts B +75 more
core +1 more source
The Reconfiguration Pattern of Individual Brain Metabolic Connectome for Parkinson's Disease Identification [PDF]
arXiv, 2021 Background: Positron Emission Tomography (PET) with 18F-fluorodeoxyglucose (18F-FDG) reveals metabolic abnormalities in Parkinson's disease (PD) at a systemic level. Previous metabolic connectome studies derived from groups of patients have failed to identify the individual neurophysiological details.
arxiv
Circadian regulation of glucose, lipid, and energy metabolism in humans. [PDF]
, 2018 The circadian system orchestrates metabolism in daily 24-hour cycles. Such rhythms organize metabolism by temporally separating opposing metabolic processes and by anticipating recurring feeding-fasting cycles to increase metabolic efficiency.
Jamshed, H +2 more
core
TREM2-dependent effects on microglia in Alzheimer\u27s Disease [PDF]
, 2018 Alzheimer’s disease (AD) is a late-onset dementia characterized by the deposition of amyloid plaques and formation of neurofibrillary tangles (NFTs) which lead to neuronal loss and cognitive deficits.
Colonna, Marco +2 more
core +3 more sources
Localization of sterols and oxysterols in mouse brain reveals distinct spatial cholesterol metabolism [PDF]
, 2020 Dysregulated cholesterol metabolism is implicated in a number of neurological disorders. Many sterols, including cholesterol and its precursors and metabolites, are biologically active and important for proper brain function. However, spatial cholesterol
Angelini, Roberto +10 more
core +2 more sources
Journal of Diabetes Research, 2022 Background. Chronic kidney disease (CKD) is a main health problem associated with increased risk of cardiovascular disease, morbidity, and mortality.
Xinyi Du +4 more
doaj +1 more source