Results 141 to 150 of about 1,686,019 (401)

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni, Cecile Pagan, Antony Citterio‐Quentin, Isabelle Rouvet, Giulia Dingeo, Cyril Hanin, Claudine Laurent‐Levinson, Samia Pichard, Bénédicte Héron, Clément Gourguechon, Daniele Mandia, Jerome Guitton, Carole Lacout, Nicolas Schleinitz, Florient Potier, Olivier Flabeau, Elsa Besse‐Pinot, Foudil Lamari, Magali Pettazzoni, Yann Nadjar   +19 more
wiley   +1 more source

Complement factor D (adipsin) mediates pressure-pain hypersensitivity post destabilization of medial meniscus injury

Arthritis Research & Therapy
Background Osteoarthritis (OA) is the leading cause of pain worldwide. However, clinical discordance between pain and cartilage damage presents challenges in determining the mechanisms of OA pain, thus creating a need for well-controlled models that ...
Priscilla M. Tjandra, Bethany A. Andoko, Jooyoung A. Kim, Jacob G. Brockert, Andreana G. Gomez, Sonya Sar, Megha R. Aepala, Tiffany T.K. Pham, Darren Dumlao, Hope D. Welhaven, Kelsey H. Collins   +10 more
doaj   +1 more source

Endophytic bacteria with allelopathic potential regulate gene expression and metabolite production in host Casuarina equisetifolia

Frontiers in Plant Science
IntroductionCasuarina equisetifolia is a common protective forest in coastal areas. However, artificial C. equisetifolia forests cannot self-renew, mainly due to the accumulation of allelochemicals.
Ying Wang, Pan Chen, Qi Lin, Linzhi Zuo, Lei Li   +4 more
doaj   +1 more source

Flux cost functions and the choice of metabolic fluxes

, 2018
Metabolic fluxes in cells are governed by physical, biochemical, physiological, and economic principles. Cells may show "economical" behaviour, trading metabolic performance against the costly side-effects of high enzyme or metabolite concentrations ...
Liebermeister, Wolfram
core  

Flow rate of transport network controls uniform metabolite supply to tissue

, 2018
Life and functioning of higher organisms depends on the continuous supply of metabolites to tissues and organs. What are the requirements on the transport network pervading a tissue to provide a uniform supply of nutrients, minerals, or hormones?
Alim, Karen, Meigel, Felix J.
core   +1 more source

Response to Allopurinol and Febuxostat According to the Fractional Excretion of Urate in Men With Gout

Arthritis Care &Research, EarlyView.
Objective Body mass index (BMI), glomerular filtration rate (GFR), and pretreatment urate levels have been reported to influence the urate‐lowering response to allopurinol. We investigated whether the fractional excretion of uric acid (FEUA) also modulates this response and relates to oxypurinol concentrations.
Pascal Richette, Anouk Walter‐Petrich, Quang Dinh Nguyen, Matthieu Resche‐Rigon, Quang Huy Dinh Nguyen, Minh Duc Do, Thao Phuong Mai, Tuan Duc Nguyen, Fernando Perez‐Ruiz, Emmanuel Letavernier, Tristan Pascart, Augustin Latourte, Hang Korng Ea, Thomas Bardin   +13 more
wiley   +1 more source

The interaction between gut microbiota and hibernation in mammals

Frontiers in Microbiology
Hibernation, an evolved survival trait among animals, enables them to endure frigid temperatures and food scarcity during the winter months, and it is a widespread phenomenon observed in mammals.
Peng Gao, Wenjing Shen, Tingbei Bo
doaj   +1 more source

Isolation of 10 cyclosporine metabolites from human bile [PDF]

, 1989
Ten metabolites of cyclosporine were isolated from the ethyl ether extract of bile from four liver transplant patients receiving cyclosporine. Two of the metabolites were unique and previously unidentified.
Burckart, GJ, Hartman, NR, Jardine, I, Knapp, JE, Lin, FT, Starzl, TE, Venkataramanan, R, Wang, CP   +7 more
core  

Harnessing Fungal Biowelding for Constructing Mycelium‐Engineered Materials

Advanced Engineering Materials, EarlyView.
Mycelium‐bound composites (MBCs) offer low‐carbon alternatives for construction, yet interfacial bonding remains a critical challenge. This review examines fungal biowelding as a biocompatible adhesive, elucidating mycelium‐mediated interfacial mechanisms and their role in material assembly. Strategies to optimize biowelding are discussed, highlighting
Xue Brenda Bai, Xinrui Sarah Niu, Zhao Qin   +2 more
wiley   +1 more source

Valine induces inflammation and enhanced adipogenesis in lean mice by multi-omics analysis

Frontiers in Nutrition
IntroductionThe branched-chain amino acids (BCAAs) are essential to mammalian growth and development but aberrantly elevated in obesity and diabetes. Each BCAA has an independent and specific physio-biochemical effect on the host.
Hui-Yi Zheng, Hui-Yi Zheng, Li Wang, Li Wang, Rong Zhang, Rong Zhang, Ran Ding, Ran Ding, Cai-Xia Yang, Cai-Xia Yang, Zhi-Qiang Du, Zhi-Qiang Du   +11 more
doaj   +1 more source