Results 271 to 280 of about 535,210 (299)
Transport of Metabolites [PDF]
Protoplasma, 1967 Transport phenomena have a fundamental role in cellular activity. The evidence of a limiting barrier is given by the fact that the content of living cells differs from that of the medium. In most cases the concentration of K+ in the cell is ten or more times higher than that of Na+, even in cells immersed in a medium where Na+ concentration exceeds K+.
O. Barnabei +3 more
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Metabolites of Demoxepam, a Chlordiazepoxide Metabolite, in Man
Journal of Pharmaceutical Sciences, 1972The biotransformation of demoxepam, 7-chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one 4-oxide, was studied in two subjects. Following the administration of a 20-mg. oral dose of demoxepam-2-14C, these subjects excreted 24 and 29% of the dose in the urine as unchanged drug. The urinary metabolites included “opened lactam” (formed by hydrolysis of
Morton A. Schwartz, Edward Postma
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Clinical Toxicology, 1976
The results of the animal experiment demonstrate that oxidative hydroxylation is the major mode of metabolism of phencyclidine. It is evident that this process takes place in all three rings of the molecule. Hydroxylation of the piperidyl moiety probably also accounts for the formation of the N-dealkylated metabolites.
K. Biemann, Lan K. Wong
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The results of the animal experiment demonstrate that oxidative hydroxylation is the major mode of metabolism of phencyclidine. It is evident that this process takes place in all three rings of the molecule. Hydroxylation of the piperidyl moiety probably also accounts for the formation of the N-dealkylated metabolites.
K. Biemann, Lan K. Wong
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Metabolites, enzymes, and metabolite analogues
1973The smallest change in the chemical constitution of a selectively toxic agent often makes an enormous change in its biological activity, and many examples of this have been given in Chapter 2. The present chapter deals in greater detail with one cause of high specificity, namely a close resemblance between (a) the normal substrate (or coenzyme) of an ...
Adrien Albert, Adrien Albert
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Journal of Pharmaceutical Sciences, 1974
Microbial transformation of the alkaloid mitragynine by the fungus Helminthosporum sp. has elaborated two major metabolites. The compounds were isolated from the biological milieu and their structures were elucidated as mitragynine pseudoindoxyl and hydroxy mitragynine pseudoindoxyl.
Joseph R. Valenta +3 more
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Microbial transformation of the alkaloid mitragynine by the fungus Helminthosporum sp. has elaborated two major metabolites. The compounds were isolated from the biological milieu and their structures were elucidated as mitragynine pseudoindoxyl and hydroxy mitragynine pseudoindoxyl.
Joseph R. Valenta +3 more
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Catecholamines and their metabolites
Journal of Chromatography B: Biomedical Sciences and Applications, 1988The research on biosynthesis, physiology, pharmacology, regulation and degradation of catecholamines has continuously increased for more than 50 years. This is not unexpected because of the fact that catecholamines are involved in so many life processes such as nerve conduction, blood circulation and hormone regulations in health and disease.
David S. Goldstein, Bertil K»gedal
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The fungal metabolite austdiol [PDF]
Acta Crystallographica Section C Crystal Structure Communications, 2003 The title compound, (7R,8S)-7,8-dihydroxy-3,7-dimethyl-6-oxo-7,8-dihydro-6H-isochromene-5-carbaldehyde, C(12)H(12)O(5), is a trans-vicinal diol. Of the two fused rings, which lie approximately in the same plane, the pyran ring is almost perfectly planar, while the cyclohexenone ring adopts a slightly distorted half-chair conformation.
L. Lo Presti, R. Soave, R. Destro
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2017
This handbook compiles authoritative information about fungal metabolites and their chemistry and biotechnology. The first in the reference work series “Phytochemicals”, and written by a team of international expert authors, this book provides reference information ranging from the description of fungal natural products, over their use e.g.
Merillon, Jean-Michel +1 more
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This handbook compiles authoritative information about fungal metabolites and their chemistry and biotechnology. The first in the reference work series “Phytochemicals”, and written by a team of international expert authors, this book provides reference information ranging from the description of fungal natural products, over their use e.g.
Merillon, Jean-Michel +1 more
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2015
Dichlorodiphenyltrichloroethane (DDT) is a well-known insecticide that was introduced and widely used during World War II. In total more than 4.5 million tonnes DDT have been produced. Although its use and production stopped worldwide during the 1970s, it was reintroduced in the 2000s as a malaria vector control by the World Health Organization (WHO ...
S. Mirmigkou, J. de Boer
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Dichlorodiphenyltrichloroethane (DDT) is a well-known insecticide that was introduced and widely used during World War II. In total more than 4.5 million tonnes DDT have been produced. Although its use and production stopped worldwide during the 1970s, it was reintroduced in the 2000s as a malaria vector control by the World Health Organization (WHO ...
S. Mirmigkou, J. de Boer
openaire +3 more sources